专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-2014303333-A1 优先权日:2011-10-14 标题:Iron bisphenolate complexes and methods of use and synthesis thereof 发明人:SHAVER MICHAEL P; KOZAK CHRISTOPHER M 权利人:UNIV PRINCE EDWARD ISLAND; GENESIS GROUP INC 摘要:The present application, relates to iron bisphenolate complexes and methods of use and synthesis thereof. The iron complexes are prepared from tridentate or tetradentate ligands of Formula I: wherein R 1 and R 2 are as defined herein. Also provided are methods and processes of using the iron bisphenolate complexes as catalysts in cross-coupling reactions and in controlled radical polymerizations.
专利号:PL-162803-B1 优先权日:1990-09-17 标题:Method of synthesis of 2,4-di-/1,1-dimethylphenoxyacetic acid
专利号:RU-2419603-C2 优先权日:2006-11-17 标题 :Method for synthesis of isocyanates
专利号:PL-162805-B1 优先权日:1990-09-17 标题 :Method of synthesis of 2,4-di/1,1-dimethylpropylphenoxyacetic acid
专利号:US-5258407-A 优先权日:1991-12-31 标题 :3,4-disubstituted phenols-immunomodulating agents 发明人:WASHBURN WILLIAM N; LUSSIER BARBARA B; ILLIG CARL B; LATIMER LEE H 权利人:STERLING WINTHROP INC 摘要:Certain 3,4-disubstituted phenols and pharmaceutically acceptable salts thereof are provided which mimic IL-1 activity by inducing IL-2 synthesis and subsequent IL-2 receptor expression. Specifically, the invention provides compounds of Formula I and acid addition salts thereof: FORMULA I wherein Y is NHSO2 or SO2NH where R4 is H; Z is -O-, -NH-, -NR-, -S-, or other heteroatoms capable of hydrogen bonding with R4 to give a preferred conformation; R is alkyl; R1 is -OH; R2 is H, alkyl, cycloalkyl, aralkyl, substituted or unsubstituted aryl, or a substituted or unsubstituted nitrogen heterocyclic group having 4 to 5 nuclear carbon atoms; and R3 is a lipophilic moiety.