1,3-二氟苯置于正丁基锂,氢气体系中,用 四氢呋喃 用作溶剂,化学反应生成2,6-二氟苯硼酸 参考文献:Synthesis And Mesomorphic Properties Of Some Fluorinated Benzoate Liquid Crystals 标题:Synthesis And Mesomorphic Properties Of Some Fluorinated Benzoate Liquid Crystals 摘要:Three Series Of [4-(4'-N-Alkyloxyphenyl)Acetylenyl]-2,6-Difluorophenyl Fluorinated Benezoates And One Series Of Fluorinated Benzoates With 2,3,5,6-Tetrafluorophenylene Group And Semi-Perfluorocarbon Chain Have Been Synthesized. Their Phase Transition Temperatures Have Been Measured By Texture Observation In A Polarizing Microscope And Confirmed By Dsc. For The Series Without Fluorocarbon Chains,Increasing The Quantity Of Fluorosubstituents On The Terminal Phenyl Groups Decreased Nematic Stability (Tn-1),But The Breadth Of The Sma Phase Range Was Increased. Lateral Fluorosubstitution In The Central Group Lowered The Nematic Stability (Tn-1) And Decreased The Breadth Of The Sma Phase Range. The Series With Semiperfluorocarbon Chains Were More Likely To Form Sma Phases Than The Series With Hydrogencarbon Chains,And With The Increasing Of Fluorosubstituents Quantity On The Terminal Phenyl Groups Nematic And Sma Stability (T(N-)1 And Tsma-N) Were Both Decreased. Doi:10.1080/10587250210534
专利信息
专利号:US-7301046-B2 优先权日:2002-02-25 标题:Boronate esters 发明人:PUTHIAPARAMPIL TOM THOMAS; SRINATH SUMITHRA; SRIDHARAN MADHAVAN; GANESH SAMBASIVAM 权利人:BIOCON LTD 摘要:The present invention relates to optically active boronate derivatives which are useful as intermediates for the synthesis of HMG-CoA enzyme inhibitors such as atorvastatin, cerivastatin rosuvastatin, pitavastatin, and fluvastatin.
专利号:EP-2107067-A1 优先权日:2008-04-03 标 题 :Boron catalysed peptide synthesis 发明人:QUAEDFLIEG PETER JAN LEONARD MARIO; NUIJENS TIMO; VRIES DE JOHANNES GERARDUS; KALKEREN VAN HENRI ANTONIUS 权利人:DSM IP ASSETS BV 摘要:The invention relates to a method of synthesising a dipeptide, an oligopeptide or polypeptide comprising coupling a first amino acid or peptide to a second amino acid or peptide in the presence of a boron compound comprising a boron oxygen bond, which boron compound catalyses the formation of a peptidic bond, wherein one of the stereoisomers is formed in excess of the other stereoisomer or stereoisomers.
专利号:US-11794180-B2 优先权日:2015-10-29 标 题 :Tri-(adamantyl)phosphines and applications thereof 发明人:CARROW BRAD P; CHEN LIYE 权利人:UNIV PRINCETON 摘要:In one aspect, phosphine compounds comprising three adamantyl moieties (PAd3) and associated synthetic routes are described herein. Each adamantyl moiety may be the same or different. For example, each adamantyl moiety (Ad) attached to the phosphorus atom can be independently selected from the group consisting of adamantane, diamantane, triamantane and derivatives thereof. Transition metal complexes comprising PAd3 ligands are also provided for catalytic synthesis including catalytic cross-coupling reactions.