CAS: 42373-30-8; 4-Aminonicotinaldehyde

相似化合物

116026-93-8 16135-36-7 7418-65-7

上下游产品

N-(3-formylpyridin-4-yl)-2,2-dimethylpropanamide -3-pyridinecarboxaldehyde4--3-pyridinecarboxaldehyde 4-nitro-3-pyridinecarbaldehyde 1-oxide 3-methyl-4-nitropyridine N-oxide 1,6-naphthyridine-2-carboxylic acid 8-bromo-[1,6]-naphthyridine-2-carboxylic acid N-(2-methoxybenzyl)-2-(1,6)naphthyridinecarboxamide

3-甲基-4-硝基吡啶-N-氧化物置于palladium On Activated Charcoal Sodium Periodate,氢气体系中,用 四氢呋喃,甲醇,水,N,N-二甲基甲酰胺 作为反应溶剂,20.0~150.0 °C,101.33 Kpa 条件下,反应 3.0H,反应生成 4-氨基-3-吡啶甲醛
参考文献:4-Aminopyridine Derivatives With Antiamnesic Activity
标题:4-Aminopyridine Derivatives With Antiamnesic Activity
摘要:Acetylcholine (Ach) Enhancement,Useful In The Treatment Of Alzheimer'S Disease (Ad),May Be Obtained By Means Of Ion Channel Modulators Such As 4-Aminopyridine (4-Ap). 4-Ap Is Also The Central Ring Of Tacrine,The First Drug Approved For The Treatment Of Ad. The Synthesis And Pharmacological Activity Of Three 4-Ap Derivatives,Prepared With The Aim Of Improving Their Antiamnesic Activity,Is Here Described. In Two Of These Compounds 4-Ap Is Connected To 4-Aminobutyric Acid (Gaba),Whereas In The Third It Is Connected To 2-Indolinone,I.E.,The Skeleton Of Linopirdine,Another Ach Enhancing Agent. The New Compounds Showed Potent Antiamnesic Activity In Comparison With Piracetam. (C) 2000 Edition Scientifiques Et Medicales Elsevier Sas.
DOI:10.1016/s0223-5234(00)00103-3

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-4894456-A
优先权日:1987-03-31
标题 :Synthesis of camptothecin and analogs thereof
发明人：WALL MONROE E; WANI MANSUKH C; NICHOLAS ALLAN W; MANIKUMAR GOVINDARAJAN
权利人:RES TRIANGLE INST
摘要:A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.

专利号:US-4981968-A
优先权日:1987-03-31
标题:Synthesis of camptothecin and analogs thereof
发明人：WALL MONROE E; WANI MANSUKH C; NICHOLAS ALLAN W; MANIKUMAR GOVINDARAJAN
权利人:RES TRIANGLE INST
摘要:A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.

专利号:EP-0436653-A4
优先权日:1988-09-28
标题 :Synthesis of camptothecin and analogs thereof

专利号:WO-9003169-A1
优先权日:1988-09-28
标题 :Synthesis of camptothecin and analogs thereof

专利号:EP-0436653-A1
优先权日:1988-09-28
标 题:Synthesis of camptothecin and analogs thereof