CAS: 5393-81-7; 2-Hydroxydecanoic Acid

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1119-86-4 2507-55-3 617-73-2

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CAS号334-48-5 正癸酸 | CAS号2623-95-2 2-溴癸酸 | CAS号42512-96-9 α-Acetoxy-undec... | CAS号17049-49-9 正辛基镁溴盐 | CAS号110-38-3 癸酸乙酯 | CAS号124-19-6 正壬醛 | CAS号124838-34-2 1,1,1-tris(meth... | CAS号141329-99-9 2-hydroxy-N-phe... | CAS号124-19-6 正壬醛 | CAS号124-38-9 二氧化碳 | CAS号7732-18-5 水 | CAS号112-05-0 正壬酸 | CAS号2404-44-6 1,2-环氧癸烷 | CAS号1119-86-4 1,2-癸二醇 | CAS号333-60-8 2-oxodecanoic acid | CAS号70267-24-2 (R)-2-hydroxyde... | CAS号71271-24-4 (±)-2-羟基癸酸甲酯

正癸酸置于p450Cla,双氧水体系中,用 Aq. Phosphate Buffer,乙醇 作为反应溶剂,化学反应 12.5H,以95%的收率获得产物羟基癸酸
参考文献:通过羧酸的形式对映选择性生物催化胺化制备规范和非规范α-氨基酸的不对称合成
标题:通过羧酸的形式对映选择性生物催化胺化制备规范和非规范α-氨基酸的不对称合成
摘要:从可再生原料和使用温和的反应条件化学和生物催化合成非规范α-氨基酸(ncaas)尚未得到有效解决.在这里,我们展示了一种三步,可扩展且模块化的单锅生物梯级的开发,该级联可将可再生脂肪酸(fas)线性转化为对映纯l-α-氨基酸.在模块1中,P450过氧合酶p450 Cla催化fa的选择性α-羟基化.通过使用自动化的H2O 2补充系统,可以将多种fa(c6:0至c16:0)的fa有效转化(46%至> 99%; Ttn> 3300),转化为有价值的α-羟基酸(α-Has; > 90%α-选择性)以制备规模显示(最大2.3 G L-1隔离产品).在模块2中,氧化还原-中性氢借入级联反应(酒精脱氢酶/氨基酸脱氢酶)使α-Has进一步转化为l-α-Aas(20%至99%).对映体纯的l-α-Aas(ee> 99%),包括药物合成的l-高苯丙氨酸,产品滴定度最高可达2.5 G L-1.该生
DOI:10.1002/adsc.201801377

专利信息

专利号:US-3758509-A
优先权日:1969-05-13
标 题 :Aryl ketals of polycyclic oxo compounds and processes
发明人：ROSENBERGER M; SAUCY G
权利人:HOFFMANN LA ROCHE
摘要:THE INTERMEDIATES AND PROCESSES OF THIS DISCLOSURE PROVIDE A NEW STEREO-SPECIFIC TOTAL SYNTHESIS OF STEROIDAL MATERIALS HAVING KNOWN VALUABLE PHARMACOLOGICAL PROPERTIES. A FUNDAMENTAL FEATURE OF THIS DISCLOSURE IS THE UTILIZATION OF ARYL KETALS, PREFERABLY PHENYLENEDIOXY KETALS DERIVED FROM CATECHOL AS PROTECTIVE GROUPS FOR OXO MOIETIES IN THE POLYCYCLIC INTERMEDIATES USED IN THE AFORESAID TOTAL SYNTHESIS.

专利号:US-2024254395-A1
优先权日:2021-06-02
标题 :Pyrolysis of polyurethane compound-containing material in order to recover raw materials
发明人：EIDEN STEFANIE; BELLINGHAUSEN RAINER; WOLF AUREL; HAHN CHRISTIAN; LODDENKEMPER TIM; JENDRZOK CAROLA
权利人:COVESTRO DEUTSCHLAND AG
摘要:The invention relates to a process according to claim 1 and pyrolysis devices used therein for the pyrolysis of pyrolysis stock comprising polyurethane-containing material, allowing carrying out pyrolysis on an industrial scale. According to the invention, even with higher amounts of pyrolysis stock an amount of pyrolysis product is obtained that contains cleavage products which can be reused for the synthesis of polyurethane-containing material.

专利号:US-2024352216-A1
优先权日:2021-08-20
标 题:Pyrolysis of a polymeric polyurethane compound in order to recover raw materials
发明人：EIDEN STEFANIE; BELLINGHAUSEN RAINER; WOLF AUREL; ALBACH ROLF
权利人:COVESTRO DEUTSCHLAND AG
摘要:The invention relates to a method according to claim 1 for the commercial implementation of a pyrolysis, and to pyrolysis devices for the pyrolysis of pyrolysis stock used in this method. The pyrolysis stock contains a polymeric compound having at least one structural polyurethane unit of the formula (I), wherein Q is a hydrocarbon group with 2 to 8 carbon atoms, preferably 3 to 8 carbon atoms, and n represents a number from 2 to 4, most preferably 2, and -* represents a covalent bond to the polymer backbone. The method and the pyrolysis device according to the invention allow, even with higher compounds of pyrolysis stock an amount of pyrolysis product to be obtained that contains cleavage products which can be reused for the synthesis of polyurethane-containing material.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5498786-A
优先权日:1991-01-31
标 题 :Synthesis of intermediates in the preparation of ACAT inhibitors
发明人：KELLY SARAH E; CHANG GEORGE
权利人:PFIZER
摘要:This invention relates to novel processes for synthesizing intermediates in the preparation of N-aryl and N-heteroarylamide inhibitors of the enzyme acyl coenzyme A: cholesterol acyltransferase (ACAT), and to novel intermediates used in such processes.

专利号:US-5656634-A
优先权日:1991-03-21
标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
发明人：CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J
权利人:PFIZER
摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.