CAS: 554-44-9; Allithiamine
- 英文名称Allithiamine
- 中文名称蒜硫胺
- IUPAC名称(E)-N-(3-(allyldisulfaneyl)-5-hydroxypent-2-en-2-yl)-N-((4-amino-2-methylpyrimidin-5-yl)methyl)formamide
- 其它别名Allithiamine; N-[(4-Amino-2-Methyl-5-Pyrimidinyl)Methyl]-N-[4-Hydroxy-1-Methyl-2-(2-Propenyldithio)-1-Butenyl]Formamide; Formamide, N-[(4-Amino-2-Methyl-5-Pyrimidinyl)Methyl]-N-[4-Hydroxy-1-Methyl-2-(2-Propen-1-Yldithio)-1-Buten-1-Yl]-; N-[(4-Amino-2-Methylpyrimidin-5-yl)Methyl]-N-[(Z)-5-Hydroxy-3-(Prop-2-Enyldisulfanyl)Pent-2-En-2-Yl]Formamide; Thiamine Impurity 81 (Mixture Of E/z-Isomers)
- CAS编号554-44-9
- MFCD编号:MFCD18910604
- FDA UNII编号:83SWN21920
- 分子式:C15H22N4O2S2
- 分子量:354.5
- 产品CID: 2512428
- 同类组份化合物CAS60160-54-5 (HCl)554-44-9 (free base)1469373-13-4 (free base)
- 产品分类有机原料 → 有机杂环化合物 → 二嗪类
物理性质
MSDS等安全信息
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专利信息
专利号:CN-107903254-A
优先权日:2017-10-10
标题 :A new synthesis process of thiamine nitrate
专利号:CN-107652281-A
优先权日:2017-10-10
标 题 :A continuous crystallization synthesis device of thiamine nitrate and its crystallization process
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主要参考文献
1: Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives Marie-Laure Volvert, Sandrine Seyen, Marie Piette, Brigitte Evrard, Marjorie Gangolf, Jean-Christophe Plumier, Lucien Bettendorff BMC Pharmacol. 2008;
8: 10. Published online 2008 Jun 12. doi: 10.1186/1471-2210-8-10 ) Attila Biro, Ferenc Gál, Csaba Hegedűs, Gyula Batta, Zoltán Cziáky, Barna Peitl, László Stündl, Gyöngyi Gyémánt, Judit Remenyik Heliyon. 2018 Dec; 4(12): e00997. Published online 2018 Dec 8. doi: 10.1016/j.heliyon.2018.e00997 2006 Mar; 3(1): 49–59. Published online 2006 Feb 1. doi: 10.1093/ecam/nek009 2013;
11: 182. Published online 2013 Aug 15. doi: 10.1186/1741-7015-11-182 2013;
合成参考文献
摘要:Lonsdale D. Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent. Med Sci Monit. 2004 Sep;10(9):RA199–203.
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