CAS: 555-21-5; 4-Nitrophenylacetonitrile

上下游产品

CAS号140-29-4 苯乙腈 | CAS号18293-53-3 (三甲硅基)乙腈 | CAS号586-78-7 对溴硝基苯 | CAS号773837-37-9 sodium cyanide | CAS号100-14-1 4-硝基氯化苄 | CAS号76254-70-1 2-(4-硝基苯基)乙烷硫代酰胺 | CAS号724767-53-7 tert-butyl cyan... | CAS号1058649-42-5 4-nitro-1-[(eth... | CAS号10442-39-4 氰化四丁基胺 | CAS号139884-17-6 1-(methoxymetho... | CAS号50712-63-5 2-(4-硝基苯基)丙腈 | CAS号5445-26-1 对硝基苯乙酸乙酯 | CAS号3544-25-0 对氨基苯乙腈 | CAS号5438-70-0 4-氨基苯乙酸乙酯 | CAS号51628-12-7 4-碘苯乙腈 | CAS号91392-33-5 1-(4-硝基苯基)环戊甲腈 | CAS号206360-56-7 2,2-二氟-2-(4-硝基苯基)乙酸 | CAS号19159-93-4 Benzeneacetonit... | CAS号19756-72-0 4-硝基苯甲酸叔丁酯

苯乙腈置于硫酸,硝酸体系中,化学反应 1.0H,以88%的收率获得产物对硝基苯乙腈
参考文献:新型咔唑-二苯乙烯杂化物作为多功能抗阿尔茨海默病药物.
标题:新型咔唑-二苯乙烯杂化物作为多功能抗阿尔茨海默病药物.
摘要:能够与多种与阿尔茨海默氏病病理状况相关的靶标结合的分子已被证明是潜在的抗阿尔茨海默氏症药物.在我们开发用于治疗阿尔茨海默氏病的多靶标定向配体的目标中,通过咔唑环与苯乙烯骨架的融合,设计了一系列基于咔唑的新衍生物.合成并设计了所设计的化合物的抗ad活性,包括抑制胆碱酯酶,抑制aβ聚集,抗氧化剂和金属螯合特性.其中,(e)-1-(4-(2-(2-(9-乙基-9 H-咔唑-3-基)乙烯基)苯基)-3-(2-(吡咯烷-1-基)乙基)硫脲(50)似乎是对ache(ic具有非常好抑制活性的最佳候选药物50值为2.64μm)和buche(ic 50值为1.29μm),并显着抑制了自我介导的aβ1-42聚集(25μm浓度下为51.29%).金属螯合研究表明化合物(50)具有特定的铜离子螯合性能.另外,化合物(50)表现出中等的抗氧化剂活性.为了理解50的结合模式,进行了分子对接研究,结果表明50与ache,
DOI:10.1016/j.Bioorg.2020.103977

专利信息

专利号:US-9834556-B2
优先权日:2014-03-24
标题 :Process of preparing 3-(3-(4-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-YL)pyridin-2-amine
发明人：BATES CRAIG; CHEN JIAN-XIE; MAO JIANMIN; REED DAVID P
权利人:ARQULE INC
摘要:The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine:

专利号:WO-2019081972-A1
优先权日:2017-08-09
标题:PROCESS FOR THE PREPARATION OF 4-NITROPHENYL ETHYLAMIDE MANDELIC ACID FROM 4-NITROBENZYL CYANIDE
发明人：HORAK RADIM; GREPL MARTIN; FUNK PETR; KORISTRK KAMIL; KVAPIL LUBOMIR; URBASEK MIROSLAV; HRADIL PAVEL
权利人:SANECA PHARMACEUTICALS A S
摘要:The invention relates to the preparation of a salt of 4-nitrophenylethylamine with (R) -mandelic acid and its use for the synthesis of mirabegron. The invention relates to the preparation of 4-nitrophenylethylamine (1) by reduction of 4-nitrobenzyl cyanide (7) in a solvent with the use of a borane generated in situ in a reaction mixture from NaBH 4 and BF 3 .And 2 O. the 4-nitrophenyl ethylamine (1) according to the present invention is isolated from the solution as a mandelate 3.

专利号:US-4499026-A
优先权日:1982-08-25
标题 :Nucleophilic substitution process
发明人：STAHLY BARBARA C; STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Nitroarylacetonitriles are prepared by reacting a nitroaromatic compound which is devoid of halogen on the aromatic ring carrying a nitro group with an alpha,alpha-disubstituted acetonitrile in an inert solvent and in the presence of a base so that the nitrile undergoes a nucleophilic substitution on an unsubstituted ring carbon of the nitroaromatic compound during which an alpha-substituent functions as a leaving group. Nitrobenzene acetic acids and their nitriles are useful intermediates for the synthesis of pharmaceuticals.

专利号:CN-111732493-A
优先权日:2017-01-16
标题 :A kind of synthesis technique of aromatic amine compound

专利号:CN-1718574-A
优先权日:2004-07-09
标 题:1,2,3, the chemical synthesis process of 4-tetrazole compound

专利号:CN-108164435-A
优先权日:2018-01-26
标题:A green and efficient synthesis method of aryl acrylonitrile compounds