CAS: 637-81-0; Ethyl Azidacetate

上下游产品

CAS号105-36-2 溴乙酸乙酯 | CAS号105-39-5 氯乙酸乙酯 | CAS号623-33-6 甘氨酸乙酯盐酸盐 | CAS号623-48-3 碘代醋酸乙酯 | CAS号4648-54-8 叠氮基三甲基硅烷 | CAS号29169-19-5 2-(甲基磺酰氧基)乙酸乙酯 | CAS号861570-78-7 (N-nitroso-hydr... | CAS号459-73-4 2-胺基乙酸乙酯 | CAS号332099-36-2 3-溴-4h-噻吩并[3,2-... | CAS号38922-77-9 咪唑并[1,2-|a|]吡啶-... | CAS号143982-44-9 ethyl 2-azido-3... | CAS号46193-76-4 4H-噻吩[3,2-b]吡咯-... | CAS号459-73-4 2-胺基乙酸乙酯 | CAS号1816-91-7 Acetamide, 2-azido | CAS号202003-10-9 (4-氰基-1H-1,2,3-... | CAS号18523-48-3 叠氮乙酸 | CAS号27737-55-9 2-乙酸基-4-苄氧基吲哚 | CAS号1033434-57-9 ethyl α-azido-β...

溴乙酸乙酯置于sodium Azide体系中,用 乙腈 作为反应溶剂,化学反应 4.0H,以90%的收率获得产物叠氮乙酸乙酯
参考文献:铜 (I)-催化 O-炔丙基podocarpate 甲酯和叠氮化物在室温下的环加成反应
标题:铜 (I)-催化 O-炔丙基podocarpate 甲酯和叠氮化物在室温下的环加成反应
摘要:摘要 碘化铜作为一种有效的催化剂,在室温下通过甲基 O-炔丙基podocarpate 和炔丙基o-Propargylpodocarpate 与叠氮化物的"点击"化学环加成反应合成罗汉果酸的1,2,3-三唑衍生物.
DOI:10.1080/00397911.2010.492081

专利信息

专利号:WO-2011090968-A1
优先权日:2010-01-22
标题:Post-synthetic chemical modification of rna at the 2'-position of the ribose ring via 'click' chemistry
发明人：ZEWGE DANIEL; GOSSELIN FRANCIS
权利人:MERCK SHARP & DOHME; ZEWGE DANIEL; GOSSELIN FRANCIS
摘要:This invention relates to the post-synthetic chemical modification of RNA at the 2'-position on the ribose ring via a copper catalyzed Huisgen cycloaddition ('click' chemistry: Kolb, Sharpless Drug Discovery Today 2003, 8, 1128). The invention 1) avoids complex, tedious multi-step syntheses of each desired modified ribonucleoside; 2) allows diverse chemical modifications using high-fidelity chemistry that is completely orthogonal to commonly used alkylamino, carboxylate and disulfide linker reactivities; 3) allows introduction of functional groups that are incompatible with modern automated solid-phase synthesis of RNA and subsequent cleavage-deprotection steps; 4) allows introduction of functional groups useful as targeting ligands; and 5) enables high-throughput structure-activity relationship studies on chemically modified RNA in 96-well format.

专利号:US-11173212-B2
优先权日:2017-09-28
标 题 :Supramolecular protein assemblies with advanced functions and synthesis thereof
发明人：BRITTO Sandanaraj Selvaraj; BHANDARI PAVANKUMAR JANARDHAN; REDDY Mullapudi Mohan
权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES
摘要:The present invention discloses stimuli-sensitive protein conjugate which can make supramolecular protein assemblies and methods for using the same. The present invention provides simple and rational process for construction of said stimuli-sensitive spherical protein assemblies through supramolecular chemical strategy.

专利号:WO-03000690-A1
优先权日:2001-06-25
标题:Synthesis of heterocyclic compounds employing microwave technology
发明人：MAJID TAHIR NADEEM; DEPRETS STEPHANIE D; PEDGRIFT BRIAN L
权利人:AVENTIS PHARMA INC; MAJID TAHIR NADEEM; DEPRETS STEPHANIE D; PEDGRIFT BRIAN L
摘要:This invention provides for processes for preparing compounds of the formula (I) comprising employing microwave energy.

专利号:US-5200546-A
优先权日:1991-09-30
标 题 :Phosphonoalkyl phenylalanine compounds suitably protected for use in peptide synthesis
发明人：BURKE JR TERRENCE R; LIM BENJAMIN B
权利人:US HEALTH
摘要:There are disclosed novel compounds of the formula: ##STR1## wherein, x is --CH 2 --, --CHF--, --CF 2 , --CHOH-- or --C(O)--; n R 6 is hydrogen, benzyl, pentafluorophenyl, nitrophenyl, 1-benzotriazolyl or 1-succinimidoyl; n Fmoc is 9-fluorenylmethyloxycarbonyl; and n * indicates a chiral carbon atom. n The Formula (I) compounds are useful in synthesizing peptides. There are also disclosed novel synthesis methods which include the step of hydrogenating a compound of the Formula ##STR2## wherein R 4 and R 5 are C 1-8 lower alkyl, to give a compound of the formula ##STR3## wherein R 4 and R 5 are as defined above. The compounds of formula (II) are useful as intermediates in preparing certain formula (I) compounds.

专利号:WO-2011047481-A1
优先权日:2009-10-23
标题 :Novel spiro compounds useful as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：FORTIN REJEAN; LACHANCE NICOLAS; LI CHUN SING; TRANMER GEOFFREY
权利人:MERCK FROSST CANADA LTD; FORTIN REJEAN; LACHANCE NICOLAS; LI CHUN SING; TRANMER GEOFFREY
摘要:Heteroaromatic compounds of structural formula I are selective inhibitors of stearoyl- coenzyme. A delta-9 desaturase (SCDl) relative to other known stearoyl-coenzyme. A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis. Formula (I).

专利号:US-2009176968-A1
优先权日:2006-06-20
标 题 :Preparation of Triazole Containing Metal Chelating Agents
发明人：MINDT THOMAS; SCHIBLI ROGER
权利人:SCHERRER INST PAUL
摘要:New chelating agents as well as their tricarbonyl complexes with technetium and rhenium and the use of these compounds in radiodiagnosis and radiotherapy are described. As a peculiarity of this invention, synthesis and coupling of the chelating systems to (bio)molecules is performed simultaneously. The new chelating agents are coupled to substances that accumulate in the diseased/targeted tissue.