CAS: 67169-22-6; 2-Methyl-4-(Trifluoromethyl)Aniline

该化合物是一种含氟芳烃的芳香矿,有三氟甲基替代物,具有强化电子提取特性和化学稳定性,其独特结构使其作为制药,农用化学品和特殊材料合成的中间体具有价值.该化合物在电益替代反应中表现出了更高的反应性,并成为先进的有机框架的多功能构件.

英文名称2-Methyl-4-(Trifluoromethyl)Aniline
中文名称2-甲基-4-(三氟甲基)苯胺
IUPAC名称2-methyl-4-(trifluoromethyl)aniline
其它别名2-甲基-4-三氟甲基苯胺; Zr B1 Dxfff [wln]
CAS编号67169-22-6
MFCD编号:MFCD03701068
EINECS号:689-838-1
分子式:C8H8F3N
分子量:175.15
产品CID: 1653842
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: PAXQXJDYVORMOO-UHFFFAOYSA-N
InChI=1S/C8H8F3N/c1-5-4-6(8(9,10)11)2-3-7(5)12/h2-4H,12H2,1H3…
计算化学: 氢键受体数1.0氢键供体数1可旋转键数0

MSDS等安全信息

GHS象形图
GHS符号GHS06;
注释: Skull and crossbones
危险类别急性毒性类别3(吸入)
急性毒性类别3(经皮)
急性毒性类别3(经口)
警示词Danger(危险)
危险描述H331 |吸入会中毒.
H311 |皮肤接触会中毒.
H301 |吞咽会中毒.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
危险等级6.1
UN编号2810.0
危险品标志T
包装等级Ⅲ
安全声明26-36/37/39
危险类别码20/21/22-36/37/38

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

2917586-13-9 = 67169-22-6 + 88301-98-8
反应条件:1.1 Reagents: Potassium Carbonate,Iodobenzene Diacetate Solvents: Dimethyl Sulfoxide; 12 H,45 °C
标题:N-Trifluoromethyl Succinimide As A New Reagent For Direct C-H Trifluoromethylation Of Free Anilines
作者:Liu,Hao; Et Al
参考文献:Chemistry - An Asian Journal 日期:2023 卷标:18(8)]

59239-83-7 + 128-08-5 = 67169-22-6 + 88301-98-8
反应条件:1.1 Solvents: Acetonitrile; -10 °C; 15 Min,-10 °C; 15 Min,Rt2.1 Reagents: Potassium Carbonate,Iodobenzene Diacetate Solvents: Dimethyl Sulfoxide; 12 H,45 °C
标题:N-Trifluoromethyl Succinimide As A New Reagent For Direct C-H Trifluoromethylation Of Free Anilines
作者:Liu,Hao; Et Al
参考文献:Chemistry - An Asian Journal 日期:2023 卷标:18(8)]

81290-20-2 = 67169-22-6 + 88301-98-8
反应条件:1.1 Reagents: Silver Fluoride Solvents: Acetonitrile; -10 °C; 15 Min,-10 °C; 5 Min,-10 °C -> Rt2.1 Solvents: Acetonitrile; -10 °C; 15 Min,-10 °C; 15 Min,Rt3.1 Reagents: Potassium Carbonate,Iodobenzene Diacetate Solvents: Dimethyl Sulfoxide; 12 H,45 °C
标题:N-Trifluoromethyl Succinimide As A New Reagent For Direct C-H Trifluoromethylation Of Free Anilines
作者:Liu,Hao; Et Al
参考文献:Chemistry - An Asian Journal 日期:2023 卷标:18(8)

4-氨基-3-碘三氟甲苯置于四(三苯基膦)钯 Potassium Carbonate体系中,用 N,N-二甲基甲酰胺作为反应溶剂,化学反应 48.0H,反应生成 2-甲基-4-三氟甲基苯胺
参考文献:Wo2007/79186
标题:Wo2007/79186

海关参考信息

2902300000-甲苯
2903399090-其他无环烃卤化衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2008312271-A1
优先权日:2006-07-25
标题 :Azabenzimidazolyl compounds
发明人：EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-4338318-A
优先权日:1979-03-23
标题 :Novel compositions and methods
发明人：HENRICK CLIVE A; LABOVITZ JEFFREY N; FOX ROLAND T V; RATHMELL WILLIAM G; SHEPHARD MARGARET C
权利人:ZOECON CORP
摘要:Novel 1-substituted uracils, synthesis and intermediates therefor, and compositions for the control of pests.

专利号:US-4297297-A
优先权日:1979-03-23
标题 :Î±-Cyano-Î²-(substituted-anilino)-N-ethoxycarbonylacrylamide intermediates
发明人：HENRICK CLIVE A; LABOVITZ JEFFREY N; FOX ROLAND T V; RATHMELL WILLIAM G; SHEPHARD MARGARET C
权利人:ZOECON CORP
摘要:Novel 1-substituted uracils, synthesis and intermediates therefor, and compositions for the control of pests.

专利号:US-4266056-A
优先权日:1978-04-07
标题 :Phenyl uracils
发明人：HENRICK CLIVE A; LABOVITZ JEFFREY N; FOX ROLAND T V; RATHMELL WILLIAM G; SHEPHARD MARGARET C
权利人:ZOECON CORP
摘要:Phenyl uracils, synthesis and intermediates therefor, and compositions for the control of pests, especially fungi and bacteria.

专利号:RU-2181362-C2
优先权日:1996-10-24
标题:Derivatives of aminophosphonic and aminophosphinic acids, method of their synthesis and pharmaceutical compositions based on thereof

专利号:CN-117303991-A
优先权日:2023-09-21
标题 :A kind of 4-trifluoromethyl substituted aromatic amine and its synthesis method