CAS: 73365-02-3; N-Boc-D-Prolinal

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D-脯氨醇置于tea,三氧化硫吡啶体系中,用 二氯甲烷,二甲基亚砜 作为反应溶剂,化学反应 12.25H,反应生成 Boc-D-脯氨醛
参考文献:墨西哥豆甲虫epilachna Varivestis的两种防御生物碱的合成和绝对构型
标题:墨西哥豆甲虫epilachna Varivestis的两种防御生物碱的合成和绝对构型
摘要:(2的合成小号,12'-[r)-2-(12'-Aminotridecyl)-吡咯烷(1)和(2小号,12'-[r)-1-(2"-羟基乙基)-2-(12'-Aminotridecyl)-吡咯烷(2),这是最近从墨西哥甲虫epilachna Varivestis中分离出的两种防御生物碱.通过将天然生物碱2的mtpa衍生物与合成标准品的1 H NMR数据进行比较,我们确认了先前对该生物碱提出的(2 S,12'R)构型.这些分配的进一步支持是由合成和提供1个的1 H NMR调查(2S,12 'S)-1,(2 S,12 'S)-2及其mtpa衍生物.
DOI:10.1016/s0040-4039(97)01491-3

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2021261583-A1
优先权日:2018-06-14
标 题:Synthetic Cytotoxic Molecules, Drugs, Methods of Their Synthesis and Methods of Treatment
发明人：EDINGER AIMEE; HANESSIAN STEPHEN
权利人:UNIV CALIFORNIA; UNIV MONTREAL
摘要:Small molecules compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.

专利号:CA-3103805-A1
优先权日:2018-06-14
标 题:Synthetic cytotoxic molecules, drugs, methods of their synthesis and methods of treatment

专利号:US-5378690-A
优先权日:1986-12-19
标题 :New renin-inhibitory oligopeptides, their preparation and their use
发明人：MORISAWA YASUHIRO; KATAOKA MITSURU; YABE YUICHIRO; IIJIMA YASUTERU; TAKAHAGI HIDEKUNI; KOIKE HIROYUKI; KOKUBU TATSUO; HIWADA KUNIO
权利人:SANKYO CO
摘要:Oligopeptides of formula (I): (I) where R1-R5 are various organic groups, and A represents a group of formula -NH- or -(CH2)n-, in which n represents an integer of from 1 to 3, have renin-inhibitory activity and are particularly suitable for oral administration. They may be prepared by condensing their component amino acids or lower oligopeptides using conventional peptide synthesis reactions.