CAS: 844856-42-4; 3-Bromo-3'-Chloro-1,1'-Biphenyl

溴苯,3-Chlorobenzenediazonium Tetrafluoroborate置于吡啶体系中,化学反应 18.0H,反应生成 3-溴-3'-氯-1,1'-联苯,4-溴-3'-氯-1,1'-联苯,2-Bromo-3'-Chloro-1,1'-Biphenyl
参考文献:可见光促进的,无催化剂的gomberg-Bachmann反应:联芳烃的合成
标题:可见光促进的,无催化剂的gomberg-Bachmann反应:联芳烃的合成
摘要:联芳基是通过不需要光敏剂或任何金属试剂的新型可见光促进的gomberg-Bachmann反应合成的.在芳基重氮盐和吡啶之间形成电子供体-受体配合物,可以在可见光照射下以中等至高收率合成联芳基.
DOI:10.1021/acs.Joc.9B00557

专利信息

专利号:US-11286268-B1
优先权日:2019-07-02
标题:EIF4E-inhibiting compounds and methods
发明人：SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.