合成目标产物 2,4-Dimethoxybenzoic Acid 主要起始原料 1-Bromo-2,4-Dimethoxybenzene And Carbon Dioxide
613-45-6 = 91-52-1 反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Silver Nitrate Solvents: Acetonitrile; Rt -> 50 °C; 1.5 H,50 °C1.2 Reagents: Sodium Thiosulfate Solvents: Water 标题:Silver Nitrate-Catalyzed Oxidation Of Aldehydes To Carboxylic Acids By H2O2 作者:Chakraborty,Debashis; Et Al 参考文献:Tetrahedron Letters 日期:2009 卷标:50(47) 页码:6553-6556]
38064-90-3 = 91-52-1 反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: 1-Hexadecanaminium,N,N,N-Trimethyl-,(Pb-7-34-111′1′2)-Oxodiperoxy(2-Pyridineca... Solvents: Water; 24 H,80 °C 标题:Controlled And Predictably Selective Oxidation Of Activated And Unactivated C(Sp3)-H Bonds Catalyzed By A Molybdenum-Based Metallomicellar Catalyst In Water 作者:Thiruvengetam,Prabaharan; Et Al 参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(6) 页码:4061-4077]
2150-41-6 = 91-52-1 反应条件:1.1 Reagents: Potassium Hydroxide 标题:Alternatives To N,N-Diethyl-2,4-Dimethoxybenzamide As A Precursor For The Synthesis Of 6,8-Dimethoxy-3-Methyl-3,4-Dihydro-1-Isochromenone 作者:Van Otterlo,Willem A. L.; Et Al 参考文献:Synthetic Communications 日期:2007 卷标:37(20) 页码:3611-3621]
2150-41-6 = 91-52-1 反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Ethanol,Water; Reflux; Cooled1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified 标题:Rational Design Of Rod-Like Liquid Crystals Exhibiting Two Nematic Phases 作者:Mandle,Richard J.; Et Al 参考文献:Chemistry - A European Journal 日期:2017 卷标:23(58) 页码:14554-14562]
613-45-6 = 91-52-1 反应条件:1.1 Reagents: Hydroxyamine Hydrochloride,Hydrochloric Acid,Hydrogen Peroxide Solvents: Acetonitrile,Water; 1.5 H,80 °C1.2 Reagents: Sodium Thiosulfate Solvents: Water 标题:Selective And Efficient Oxidation Of Aldehydes To Their Corresponding Carboxylic Acids Using H2O2/HCL In The Presence Of Hydroxylamine Hydrochloride 作者:Bahrami,Kiumars; Et Al 参考文献:Chinese Journal Of Chemistry 日期:2008 卷标:26(6) 页码:1119-1121]
613-45-6 = 91-52-1 反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Tin Oxide Solvents: Acetonitrile,Water; 90 Min,60 °C 标题:Sno2 Nanoparticles: Preparation And Evaluation Of Their Catalytic Activity In The Oxidation Of Aldehyde Derivatives To Their Carboxylic Acid And Sulfides To Sulfoxide Analogs 作者:Dehbashi,Mohsen; Et Al 参考文献:Phosphorus 日期:2013 卷标:188(7) 页码:864-872
专利号:US-8742028-B2 优先权日:2009-05-06 标 题:Solid support for Fmoc-solid phase synthesis of peptide acids 发明人:SRIVASTAVA KRIPA S; DAVIS MATTHEW R 权利人:SRIVASTAVA KRIPA S; DAVIS MATTHEW R; MALLINCKRODT LLC 摘要:The present invention provides a solid support for Fmoc-solid phase synthesis of peptides. In particular, the solid supports of the invention may be utilized to produce peptide acids.
专利号:US-4400550-A 优先权日:1982-02-12 标题 :Synthesis of the navel orange worm pheromone (Z,Z)-11,13-hexadecadienal 发明人:BISHOP CLYDE E; MORROW GARY W 权利人:ALBANY INT CORP 摘要:A process for the synthesis of (Z,Z)-11-13-hexadecadienal is disclosed, starting with undecylenic alcohol.
专利号:US-6180830-B1 优先权日:1995-11-08 标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes 发明人:JACQUOT ROLAND 权利人:RHODIA CHIMIE SA 摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.
专利号:US-9453037-B2 优先权日:2011-07-28 标 题 :Methylphenidate-prodrugs, processes of making and using the same 发明人:GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB 权利人:KEMPHARM INC; KEMPHARM INC 摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
专利号:US-2009177008-A1 优先权日:2005-12-28 标题:Novel process for synthesis of itopride and its novel intermediate n-(4-hydroxybenzyl)- 3,4-dimethoxybenzamide 发明人:KHAMAR BAKULESH MAFATLAL; MODI INDRAVADAN AMBALAL; VENKATRAMAN JAYARAMAN; RAVI PONNAIAH; NORI DIVAKARA SOMAYAJULU; GAJULA MADHUSUDANA RAO; RENUGADEVI GURUSAMY; SHASHIKALA KUNJARU N; RUDRAMUNI SANTOSH M 权利人:CADILA PHARMACEUTICALS LTD 摘要:The present invention relates to a novel and improved process for the preparation of N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide—known as Itopride, via a novel intermediate N-(4Ëœhydroxybenzyl)-3,4-dimethoxybenzamide.
专利号:US-8114993-B2 优先权日:2007-02-06 标题:Use of aryl chlorides in palladium-catalyzed C-H bond functionalization 发明人:DAUGULIS OLAFS; CHIONG HENDRICH 权利人:DAUGULIS OLAFS; CHIONG HENDRICH; UNIV HOUSTON SYSTEM 摘要:A one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using chloroarenes and palladium catalysts is disclosed. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores.
摘要:Davies, G. H. M.; Wisniewski, S. R., Science of Synthesis Knowledge Updates, (2021) 2, 196. 摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2018) 3, 135. 摘要:Vashchenko, B. V.; Grygorenko, O. O., Science of Synthesis Knowledge Updates, (2021) 3, 410. 摘要:Zhang, M.; Su, W., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 113. 摘要:Kantak, A.; DeBoef, B., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 589.