CAS: 1025967-78-5; (S)-2-(2-(Benzofuran-6-Carbonyl)-5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxamido)-3-(3-(Methylsulfonyl)Phenyl)Propanoic Acid

上下游产品

立他斯特杂质 ((S)-Benzyl 2-(2-(Benzofuran-6-Carbonyl)-5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxamido)-3-(3-Methylsulfonyl)Phenyl)Propanoate 1194550-67-8
立他司特杂质c (S)-2-(5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxamido)-3-(3-(Methylsulfonyl)Phenyl)Propanoic Acid 851785-70-1
立他斯特杂质 Benzyl (S)-2-[2-(Tert-Butoxycarbonyl)-5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxamido]-3-[3-(Methylsulfonyl)Phenyl]Propanoate 1194550-61-2
2-(Benzofuran-6-Carbonyl)-5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid
2-(Benzofuran-6-Carbonyl)-5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Methyl Carboxylate 851784-92-4
N-Boc-5,7-二氯-1,2,3,4-四氢异喹啉-6-羧酸 2-(Tert-Butoxycarbonyl)-5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid 851784-82-2
N-Boc-5,7-二氯-6-甲酸甲酯-1,2,3,4-四氢异喹啉 2-(Tert-Butyl) 6-Methyl 5,7-Dichloro-3,4-Dihydroisoquinoline-2,6(1η)-Dicarboxylate 851784-80-0
(((三氟甲基)磺酰基)氧基)-3,4-二氢异喹啉-2(1H)-甲酸叔丁酯 Tert-Butyl 5,7-Dichloro-6-(((Trifluoromethyl)Sulfonyl)Oxy)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate 851784-78-6

立他司特杂质3置于n,N-二异丙基乙胺,Sodium Hydroxide体系中,用 水,丙酮 用作溶剂,以95.3%的收率获得立他司特
参考文献:立他司特的制备方法及其中间体化合物
标题:立他司特的制备方法及其中间体化合物
摘要:本发明涉及立他司特的制备方法及其中间体化合物.具体而言,本发明涉及立他司特的合成方法,用于合成立他司特的关键中间体,其溶剂化物以及其在碱性条件下水解制备立他司特的方法.

专利信息

专利号:US-9273023-B2
优先权日:2011-11-01
标 题:Modular synthesis of graphene nanoribbons and graphene substructures from oligo-alkynes
发明人：ALABUGIN IGOR; BYERS PHILIP M
权利人:UNIV FLORIDA STATE RES FOUND
摘要:A method for the synthesis of carbon-based structures, particularly graphene substructures and ribbons, from oligo- and poly-alkyne starting materials.

专利号:US-5859233-A
优先权日:1996-02-21
标 题 :Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates
发明人：HIRSCHBEIN BERNARD L; FEARON KAREN L; GRYAZNOV SERGEI M; MCCURDY SARAH N; NELSON JEFFREY S; SCHULTZ RONALD G
权利人:LYNX THERAPEUTICS INC
摘要:The invention provides a method of synthesizing oligonucleotide N3'->P5' phosphoramidates using an amine-exchange reaction of phosphoramidites in which a -deprotected 3'-amino group of a solid phase supported oligonucleotide chain is exhanged for the amino portion of a 5'-phosphoramidite of an incoming monomer which has a protected 3'-amino group. The resulting internucleotide phosphoramidite linkage is then oxidized to form a stable protected phosphoramidate linkage. The method of the invention greatly improves product yields and reduces reagent usage over currently available methods for synthesizing the above class of compound.

专利号:US-12168720-B2
优先权日:2019-02-19
标 题:Synthesis of functionalized polymers through devulcanization from waste containing elastomers
发明人：DEZ ISABELLE; GAUMONT ANNIE-CLAUDE; NOËL JEAN-NICOLAS
权利人:CENTRE NAT RECH SCIENT; UNIV CAEN; ECOLE NAT SUPERIEURE DINGENIEURS DE CAEN
摘要:A method for synthesising polymers through devulcanisation from waste containing elastomers, the method including:a) contacting the waste containing elastomers with a solvent in the presence of a devulcanisation agent,b) heating the mixture produced in step a), at a temperature of between 20° C. and 250° C. for a period of between 15 minutes and 24 hours in the presence of a devulcanisation agent, the concentration of devulcanisation agent, and the ratio between the concentration of devulcanisation agent, expressed as parts per hundred of elastomer (phr) and a volume of solvent, expressed in ml, is:greater than 0.3 phr/ml of solvent or less than 0.2 phr/ml of solvent when the method is carried out in air,greater than 0.06 phr/ml of solvent when the method is carried out in an inert atmosphere.

专利号:US-5824793-A
优先权日:1996-02-21
标题:Solid phase synthesis of oligonucleotide N3'-P5' phosphoramidates
发明人：HIRSCHBEIN BERNARD L; FEARON KAREN L; GRYAZNOV SERGEI M; MCCURDY SARAH N; NELSON JEFFERY S; SCHULTZ RONALD G
权利人:LYNX THERAPEUTICS INC
摘要:The invention provides a method of synthesizing oligonucleotide N3'->P5' phosphoramidates using an amine-exchange reaction of phosphoramidites in which a deprotected 3'-amino group of a solid phase supported oligonucleotide chain is exhanged for the amino portion of a 5'-phosphoramidite of an incoming monomer which has a protected 3'-amino group. The resulting internucleotide phosphoramidite linkage is then oxidized to form a stable protected phosphoramidate linkage. The method of the invention greatly improves product yields and reduces reagent usage over currently available methods for synthesizing the above class of compound.

专利号:US-2023135188-A1
优先权日:2017-07-06
标题:Fe/cu-mediated ketone synthesis
发明人：KISHI YOSHITO; YAHATA KENZO; KUMAR VEMULA PRAVEEN; VADDELA SUDHEER BABU
权利人:HARVARD COLLEGE
摘要:Provided herein are methods for preparing ketone-containing organic molecules. The methods are based on novel iron/copper-mediated (“Fe/Cu-mediatedâ€?) coupling reactions. The Fe/Cu-mediated coupling reaction can be used in the preparation of complex molecules, such as halichondrins and analogs thereof. In particular, the Fe/Cu-mediated ketolization reactions described herein are useful in the preparation of intermediates en route to halichondrins.

专利号:US-2018111958-A1
优先权日:2008-12-02
标 题 :Method for the synthesis of phosphorus atom modified nucleic acids