CAS: 1279691-36-9; (2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-Tetrahydrofuran-3-yl)Oxy)Benzyl)Phenyl)-6-(Hydroxymethyl)-2-Methoxytetrahydro-2H-Pyran-3,4,5-Triol

英文名称(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-Tetrahydrofuran-3-yl)Oxy)Benzyl)Phenyl)-6-(Hydroxymethyl)-2-Methoxytetrahydro-2H-Pyran-3,4,5-Triol
中文名称甲基 1-C-[4-氯-3-[[4-[[(3S)-四氢-3-呋喃基]氧基]苯基]甲基]苯基]-α-D-吡喃葡萄糖苷
IUPAC名称(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
其它别名Methyl 1-C-[4-Chloro-3-[[4-[[(3S)-Tetrahydro-3-Furanyl]Oxy]Phenyl]Methyl]Phenyl]-Alpha-D-Glucopyranoside; (2S,3R,4S,5S,6R)-2-(3-(4-((S)-Tetrahydrofuran-3-Yloxy)Benzyl)-4-Chlorophenyl)-Tetrahydro-6-(Hydroxymethyl)-2-Methoxy-2H-Pyran-3,4,5-Triol; Empagliflozin Intermediates; (2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-((S)-Tetrahydrofuran-3-Yloxy)Benzyl)Phenyl)-6-(Hydroxymethyl)-2-Methoxytetrahydro-2H-Pyran-3,4,5-Triol; Empagliflozin Intermediate3; (3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-Tetrahydrofuran-3-yl)Oxy)Benzyl)Phenyl)-6-(Hydroxymethyl)-2-Met; Empagliflozin N-1; (3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-Tetrahydrofuran-3-yl)Oxy)Benzyl)Phenyl)-6-(Hydroxymethyl)-2-Methoxytetrahydro-2H-Pyran-3,4,5-Triol
CAS编号1279691-36-9
MFCD编号:MFCD28124344
EINECS号:113-569-6
FDA UNII编号:UCE3CY4NYM
分子式:C24H29ClO8
分子量:480.94
产品CID: 440150
产品分类医药中间体 → 原料药中间体

相似结构搜索
InChIKey: YIVKIDWTTVMRBY-JZTXWIGVSA-N
InChI=1S/C24H29ClO8/c1-30-24(23(29)22(28)21(27)20(12-26)33-24)16-4-7-19(25)15(11-16)10-14-2-5-17(6-3-14)32-18-8-9-31-13-18/h2-7,11,18,20-23,…
计算化学: 氢键受体数8.0氢键供体数4.0可旋转键数7.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
警示词Warning(警告)
危险描述H302 |吞咽有害.
防范说明P264-P270-P301+P312-P330

欧盟法规

C&L通报

上下游产品

(2S,3R,4S,5S,6R)-2-(4-氯-3-(4-(((S)-3-四氢呋喃)氧代)苄基)苯基)-6-(羟甲基)四氢-2H-吡喃-2,3,4,5-四醇 1-Chloro-4-(β-D-Glucopyranos-1-yl)-2-[4-((S)-Tetrahydrofuran-3-Yloxy)-Benzyl]-Benzene 1279691-35-8

合成工艺路线路线简述

合成目标产物 (2S,3R,4S,5S,6R)-2-(3-(4-((S)-Tetrahydrofuran-3-Yloxy)Benzyl)-4-Chlorophenyl)-Tetrahydro-6-(Hydroxymethyl)-2-Methoxy-2H-Pyran-3,4,5-Triol 主要起始原料 Methanol And 1-Chloro-4-(β-D-Glucopyranos-1-yl)-2-[4-((S)-Tetrahydrofuran-3-Yloxy)Benzyl]Benzene
(文献来源)合成步骤主要原料 Methanol 和 1-Chloro-4-(β-D-Glucopyranos-1-yl)-2-[4-((S)-Tetrahydrofuran-3-Yloxy)Benzyl]Benzene

(3R,4R,5R)-5-[(1R)-1,2-二羟基乙基]-3,4-二羟基四氢呋喃-2-酮置于n-甲基吗啉,正丁基锂体系中,用四氢呋喃,正己烷,甲苯用作溶剂,化学反应 3.0H,反应生成甲基 1-C-[4-氯-3-[[4-[[(3S)-四氢-3-呋喃基]氧基]苯基]甲基]苯基]-Alpha-D-吡喃葡萄糖苷
参考文献:一种sglt-2抑制剂化合物的制备方法
标题:一种sglt-2抑制剂化合物的制备方法
摘要:本发明涉及一种sglt-2抑制剂化合物的制备方法,利用化合物a通过羟基保护,偶联反应,羟基脱保护,缩酮反应步骤得到中间体ⅰ,再通过得到的中间体ⅰ制备sglt-2抑制剂化合物.