CAS: 14002-51-8; 4-Phenylbenzoyl Chloride

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2351-37-3 80565-30-6 3218-36-8

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CAS号92-92-2 4-苯基苯甲酸 | CAS号79-37-8 草酰氯 | CAS号92-52-4 联苯 | CAS号92-66-0 4-溴联苯 | CAS号720-75-2 4-甲基联苯-2-甲酸甲酯 | CAS号3416-93-1 2-(4,5-dihydro-... | CAS号92-91-1 4-联苯乙酮 | CAS号644-08-6 4-甲基联苯 | CAS号3478-90-8 4,4'-二苯基苯甲酮 | CAS号362669-53-2 8-(4-BIPHENYL)-... | CAS号57477-98-2 3-联苯-3-氧丙酸乙酯 | CAS号362669-47-4 ETHYL 8-(4-BIPH... | CAS号3597-91-9 4-联苯甲醇 | CAS号3815-20-1 4-联苯基甲酰胺 | CAS号36330-85-5 芬布芬 | CAS号21326-80-7 1,2-二([1,1'-联苯]... | CAS号637-50-3 β-甲基苯乙烯 (顺反混合物)... | CAS号102789-95-7 (Z)-1-(4-biphen...

4-苯基苯甲酸置于氯化亚砜体系中,化学反应 0.5H,反应生成联苯-4-甲酰氯
参考文献:1-甲基-4-哌啶醇的芳香酯作为止痛剂的定量构效关系.
标题:1-甲基-4-哌啶醇的芳香酯作为止痛剂的定量构效关系.
摘要:当用小鼠热板法测定时,被1-甲基-4-哌啶醇取代的苯甲酸酯显示出止痛活性,更有效的属于吗啡-可待因范围.为了理解芳环上的取代基如何影响止痛效果,对一系列44种衍生物进行了定量的构效关系.在研究中包括的各种取代基参数中,间位和对位的lortho(邻位取代基的长度)和b1(取代基的最小宽度)或e8与效价呈负相关,而亲脂性(尤其是pi Meta)和能力氢键受体的作用增强了效力.根据qsar结果,为最佳活性定义了苯基的取代模式.
Doi:10.1021/jm00344A011

专利信息

专利号:US-4140708-A
优先权日:1975-10-16
标 题 :Asymmetric synthesis of optically active prostaglandins
发明人：CHADHA NARESH K; PARTRIDGE JR JOHN J; USKOKOVIC MILAN R
权利人:HOFFMANN LA ROCHE
摘要:An asymmetric synthesis of optically active prostaglandin F 2 α from cyclopentadiene including intermediates in this synthesis.

专利号:US-3933892-A
优先权日:1973-02-12
标题 :Asymmetric synthesis of optically active prostaglandins
发明人：CHADHA NARESH KUMAR; PARTRIDGE JR JOHN JOSEPH; USKOKOVIC MILAN RADOJE
权利人:HOFFMANN LA ROCHE
摘要:An asymmetric synthesis of optically active prostaglandin F 2 .sub.α from cyclopentadiene including intermediates in this synthesis.

专利号:US-4214099-A
优先权日:1973-10-24
标题:Intermediates for synthesis of precursors for prostaglandins
发明人：BINDRA JASJIT S; COREY ELIAS J; SCHAAF THOMAS K
权利人:PFIZER
摘要:A new synthesis of key prostaglandin precursors and intermediates employed in their preparation. The novel synthetic sequence of this invention is shorter and more efficient than those previously employed to prepare to key intermediate.

专利号:US-5714127-A
优先权日:1992-10-08
标题 :System for multiple simultaneous synthesis
发明人：DEWITT SHEILA H H; KIELY JOHN S; PAVIA MICHAEL R; SCHROEDER MEL C; STANKOVIC CHARLES J
权利人:WARNER LAMBERT CO
摘要:A system for the multiple, simultaneous synthesis of compounds preferably uses a reaction apparatus comprising a reservoir rack having a plurality of reaction wells, a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends, a holder block, having a plurality of apertures, and a manifold, which has ports to allow introduction/maintenance of a controlled environment. The manifold top wall has a plurality of apertures in axial alignment with the reaction tubes and a gasket which allows penetration by a needle in order to dispense and aspirate materials from the reaction tubes. Sealing members, such as gaskets, are placed between the holder block, manifold and reservoir rack and the components are releasably fastened together. A robotic sample processor is used to automate the synthesis process using the reaction apparatus.

专利号:US-9475814-B2
优先权日:2011-10-03
标题:Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
发明人：HOVEYDA HAMID R; DUTHEUIL GUILLAUME; FRASER GRAEME L; ROY MARIE-ODILE; EL BOUSMAQUI MOHAMED; BATT FREDERIC
权利人:EUROSCREEN SA
摘要:The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines using N-sp3 protective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I.

专利号:US-5702672-A
优先权日:1992-10-08
标 题 :Apparatus and method for multiple simultaneous synthesis
发明人：DEWITT SHEILA H H; KELL MICHAEL; PAVIA MICHAEL R; KIELY JOHN S; SCHROEDER MEL C; STANKOVIC CHARLES J; WARE STEVEN
权利人:WARNER LAMBERT CO
摘要:An apparatus for multiple, simultaneous synthesis of compounds which consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold.