CAS: 49830-37-7; 1-Aminocyclopentane-1-Carbonitrile

相似化合物

16195-83-8 52-52-8 1352999-40-6

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CAS号143-33-9 氰化钠 | CAS号120-92-3 环戊酮 | CAS号7677-24-9 三甲基氰硅烷 | CAS号7664-41-7 氨 | CAS号1003-03-8 环戊胺 | CAS号75-86-5 丙酮氰醇 | CAS号151-50-8 氰化钾 | CAS号773837-37-9 sodium cyanide | CAS号67-64-1 丙酮 | CAS号17193-28-1 顺式-2-氨基-1-环戊甲酰胺 | CAS号52-52-8 环亮氨酸 | CAS号6636-92-6 Cyclopentanecar... | CAS号83521-99-7 1,3-Diazaspiro(... | CAS号91806-24-5 N-(1-氰基环戊基)-苯甲酰胺

1-羟基环戊烷甲腈置于titanium(Iv) Isopropylate,氨,苯甲酸体系中,用 甲醇,甲基叔丁基醚 作为反应溶剂,化学反应 18.0H,以63%的收率获得产物1-氨基环戊烷甲腈
参考文献:钛催化氰基借入反应直接用氨氨化氰醇.
标题:钛催化氰基借入反应直接用氨氨化氰醇.
摘要:α-氨基腈是天然产物中的重要组成部分,也是有机化学中的重要中间介质.本文中,开发了氰醇与氨的伙伴直接胺化以合成n-未保护的α-氨基腈.该反应通过钛催化的氰基借位反应进行,该反应具有较高的原子经济性和操作简单的特点.氨可耐受各种酮或醛氰醇,并且在温和的反应条件下以中等至高收率合成了n-未保护的α-氨基腈.
DOI:10.1021/acs.Orglett.9B03194

专利信息

专利号:US-6211382-B1
优先权日:1997-07-25
标题 :Process for the preparation of 1,3-diaza-spiro (4.4) non-1-en-4-one derivatives and 1-cyano-1-acylaminocyclopentane intermediates
发明人：HUSZAR CSABA; KIS-TAMAS ATTILA; NEMETH ATTILA; NAD ZSUZSANNA; MAKOVI ZOLTAN; GAJARY ANTAL; KOLLAR ENDRE; ARANYOSI PETER; GYUERE KAROLY; MESZAROS ISTVAN; HARI ZSUZSANNA CSETRIN; SUPIC ATTILA; ZRINYI ILONA DERVALICSNE; DUBOVSZKI KATALIN; PALIN LAJOSNE; KARASH AGNES; BOGNAR ERZSEBET
权利人:SANOFI SYNTHELABO
摘要:Process for the preparation of compounds of formula (I) wherein R means hydrogen atom, or C1-6 alkyl group, or C7-12 aralkyl group or phenyl group, characterised in that a) the compound of formula (III) is reacted with a compound of formula (IV) wherein X means halogen atom or C1-5 alkoxy group or hydroxyl group, and the resulting compound of formula (II) is transformed, in a reaction medium with pH above 7, into the compound of formula (I) or b) the compound of formula (III) is reacted with an anhydride of general formula (V) and the resulting compound of formula (II) transformed, in a reaction medium with pH above 7, into the compound of formula (I), or c) a compound of formula (II) is transformed, in a reaction medium with pH above 7, into the compound of formula (I), and if desired, the resulting compounds of formula (I), before or after isolation, are transformed into acid addition salts, or the compounds of formula (I) are liberated from their acid addition salts. Thus a process for the preparation of intermediates useful in synthesis of angiotensin II antagonists is disclosed.

专利号:US-6239286-B1
优先权日:1997-07-25
标 题:Process for the preparation of 1,3-diaza-spiro (4.4) non-1-en-4-one derivatives and 1-cyano-1-acylamino-cyclopentane intermediates
发明人：KIS-TAMAS ATTILA; HUSZAR CSABA; CASTRO BERTRAND; NEMETH ATTILA; ARANYOSI PETER; GYUERE KAROLY; MESZAROS ISTVAN; ZRINYI ILONA DERVALICSN; DUBOVSZKI KATALIN; PALI LAJOSNE; GAJARY ANTAL; SUPIC ATTILA; NAD ZSUZSANNA; MAKOVI ZOLTAN; KOLLAR ENDRE; HARI ZSUZSANNA CSETRIN; KARASZA GN; BOGNAR ERZSEBET
权利人:SANOFI SYNTHELABO
摘要:Process for the preparation of compounds of formula (I) wherein R means hydrogen atom, or C1-6 alkyl group, or C7-12 aralkyl group or phenyl group, characterised in that: a) the compound of formula (III) is reacted with a compound of formula (IV) wherein X means halogen atom or C1-5 alkoxy group or hydroxyl group and the resulting compound of formula (II) is transformed in the presence of an oxidising agent in a reaction medium with pH above 7, into the compound of formula (I), or b) the compound of formula (III) is reacted with an anhydride of general formula (V) and the resulting compound of formula (II) transformed in the presence of an oxidising agent, in a reaction medium with pH above 7, into the compound of formula (I), or c) a compound of formula (II) is transformed in the presence of an oxidising agent, in a reaction medium with pH above 7, into the compound of formula (I), and if desired, the resulting compounds of formula (I), before or after isolation, are transformed into acid addition salts, or the compounds of formula (I) are liberated from their acid addition salts. Thus a process for the preparation of intermediates useful in synthesis of angiotensin II antagonists is disclosed.

专利号:CN-102285923-A
优先权日:2011-08-02
标 题 :'One-pot' synthesis of irbesartan intermediate

专利号:US-8129411-B2
优先权日:2005-12-30
标题:Organic compounds
发明人：EHARA TAKERU; GROSCHE PHILIPP; IRIE OSAMU; IWAKI YUKI; KANAZAWA TAKANORI; KAWAKAMI SHIMPEI; KONISHI KAZUHIDE; MOGI MUNETO; SUZUKI MASAKI; YOKOKAWA FUMIAKI
权利人:EHARA TAKERU; GROSCHE PHILIPP; IRIE OSAMU; IWAKI YUKI; KANAZAWA TAKANORI; KAWAKAMI SHIMPEI; KONISHI KAZUHIDE; MOGI MUNETO; SUZUKI MASAKI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. n The compounds have the formula I′ n nwherein R1, R2, T, R3 and R4 are as defined in the specification.

专利号:CN-102050761-A
优先权日:2010-12-10
标 题 :Key intermediate of irbesartan and its synthesis method and method for synthesizing irbesartan from the intermediate