CAS: 619-19-2; 2-Hydroxy-4-Nitrobenzoic Acid

该化合物是硅酸的硝酸衍生物,其特点是芳香环上有硝基和羟基功能组,该化合物主要用作有机合成的中间体,特别是在染料,药品和农用化学物的生产中,其硝基和碳基组能够多功能反应,有利于电益替代和凝聚反应. 4-硝基二酸还用于分析化学,因其发热性,作为金属离子探测的试剂.复合物显示极地溶剂中溶性中等,在标准条件下保持稳定,适合实验室和工业应用.由于潜在的刺激效应,建议适当处理.

结构式图片

相似化合物

65-49-6 2460-58-4 13684-28-1

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

2-methyl-5-nitrophenol H-benzo[1,3]dioxine7-nitro-4H-benzo[1,3]dioxine 2-chloro-4-nitrobenzoic acid 2-hydroxy-4-nitro-benzonitrile 2-hydroxy-4-nitro-benzoic acid methyl ester 2-ethoxy-4-nitro-benzoic acid ethyl ester 2-hydroxy-4-nitro-benzoic acid propyl ester 4-nitro-2-propoxy-benzoic acid

合成工艺路线路线简述

    2-溴-4-硝基苯甲酸置于barium Dihydroxide,Sodium Hydroxide,Copper (I) Acetate体系中,化学反应生成 4-硝基水杨酸
    参考文献:Justoni; Pessina,Il Farmaco,Scienza E Tecnica,1951,Vol. 6,P. 835,839
    标题:Justoni; Pessina,Il Farmaco,Scienza E Tecnica,1951,Vol. 6,P. 835,839

    海关参考信息

    专利信息


    专利号:WO-2024054881-A1
    优先权日:2022-09-07
    标题:Ligand-enabled scalable c-h hydroxylation of benzoic and phenylacetic acids at room temperature
    发明人:YU JIN-QUAN; LI ZHEN; PARK HAN
    权利人:SCRIPPS RESEARCH INST
    摘要:The application discloses industry scalable methods of using bifunctional bidentate pyridone-carboxylic acid ligands, such as 2-methyl-2-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid, that enable room-temperature Pd-catalyzed C-H hydroxylation of a broad range of benzoic and phenylacetic acids with an industry-compatible oxidant, aqueous hydrogen peroxide, at room temperature. Further disclosed are methods of derivatization of the resulting hydroxylation products, synthesis of polyfluorinated natural products coumestan or pterocarpene from phenol building blocks, and hydroxylation of ibuprofen using this methodology,

    专利号:US-8754197-B2
    优先权日:2004-07-07
    标题:Synthesis of azo bonded immunoregulatory compounds
    发明人:RIGGS-SAUTHIER JENNIFER A; EKWURIBE NNOCHIRI N
    权利人:RIGGS-SAUTHIER JENNIFER A; EKWURIBE NNOCHIRI N; BIOCON LTD
    摘要:Methods are disclosed for preparing compounds of Formula I: n nwhere R 1 , R 3 , and R 4 are independently hydrogen or C 1 to C 4 alkyl, and R 2 is:n n nwhere R 5 is selected from the group consisting of hydrogen and C 1 to C 4 alkyl, orn n nwhere R 6 , R 7 and R 8 are independently hydrogen or C 1 to C 4 alkyl; or the esters or pharmacologically acceptable salts thereof. The compounds and or their metabolites can be used to treat or prevent various diseases, particularly inflammatory conditions of the GI tract.

    专利号:US-10308595-B2
    优先权日:2013-02-15
    标 题:Albicidin derivatives, their use and synthesis
    发明人:SUESSMUTH RODERICH; KRETZ JULIAN; SCHUBERT VIVIEN; PESIC ALEXANDER; HUEGELLAND MANUELA; ROYER MONIQUE; COCIANCICH STEPHANE; ROTT PHILIPPE; KERWAT DENNIS; GRAETZ STEFAN
    权利人:UNIV BERLIN TECH
    摘要:Antibiotically active compounds characterized by general formula (I), wherein X1, BB, BC, BD, BE and X2 are building blocks with D1, D2, D3, D4 or D5 being linkers which include carbon, sulphur, nitrogen, phosphor and/or oxygen atoms and which are covalently connecting the moities BA and BB, BB and BC, BC and BD, BD and BE and BE and BF, respectively, and wherein in particular the building block BC comprises an amino acid derivative. The compounds for use in a method of treatment of diseases, in particular for use in a method of treatment of bacterial infections are also disclosed.

    专利号:US-2008033153-A1
    优先权日:2004-07-07
    标 题:Synthesis of Azo Bonded Immunoregulatory Compounds

    专利号:US-7932366-B2
    优先权日:2004-07-07
    标 题 :Synthesis of azo bonded immunoregulatory compounds

    专利号:US-8314214-B2
    优先权日:2004-07-07
    标 题:Synthesis of azo bonded immunoregulatory compounds
    嘉兴市吉拉特化工有限公司
    ⚠️ 未注册 · 未认证企业
    ⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
    数据来源于公开网络搜索,平台未作核实,请自行辨别。
    🏢敬请 企业认领
    🏬开设公司展台
    📢获取免费会员权益
    🎖️点亮专属注册企业标签
    📇展现公司完整信息 样本查看立即注册认领 →
    网址: http://www.jlightchem.com
    企业联系电话:0573-82813637;82813639👤
    📞嘉兴市吉拉特化工有限公司 ⚠️参考联系方式
    联系人:魏经理;王经理;叶经理
    电话:0573-82813637;82813639
    手机:13605839392;15857374971;15157377625
    传真:0573-82813637
    邮箱:sales@jlightchem.com
    通信地址: 浙江省嘉兴市大桥镇嘉兴工业园区东塘支路北侧
    邮编: 314006
    🆔 联系时候可告知是从"百琢研"平台获取的信息.
    ⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

    地址:浙江省嘉兴市大桥镇嘉兴工业园区东塘支路北侧
    ⚠️ 未注册 · 未认证企业
    注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别
    ✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
    北京偶合科技有限公司
    ⚠️ 未注册 · 未认证企业
    ⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
    数据来源于公开网络搜索,平台未作核实,请自行辨别。
    🏢敬请 企业认领
    🏬开设公司展台
    📢获取免费会员权益
    🎖️点亮专属注册企业标签
    📇展现公司完整信息 样本查看立即注册认领 →
    网址: http://www.ouhechem.com
    企业联系电话:010-51280831(不占线);010-82967028👤
    📞北京偶合科技有限公司 ⚠️参考联系方式
    联系人:刘先生
    电话:010-51280831(不占线);010-82967028
    手机:13911808554
    传真:010-82967029
    邮箱:sales@ouhechem.com
    通信地址: 北京市海淀区西三旗桥东上奥世纪2b-1328室
    邮编: 100096
    🆔 联系时候可告知是从"百琢研"平台获取的信息.
    ⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

    地址:北京市海淀区西三旗桥东上奥世纪2b-1328室
    ⚠️ 未注册 · 未认证企业
    注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别
    ✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
    第 1 / 1 页
    现货

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Dhan Prakash, Et Al. Novel Pathway For The Degradation Of 2-Chloro-4-Nitrobenzoic Acid By Acinetobacter Sp. Strain Rkj12. Appl Environ Microbiol. 2011 Sep;77(18):6606-13.

    合成参考文献


    摘要:González-Bello, C., Science of Synthesis Knowledge Updates, (2018) 1, 215.
    摘要:Hitomi, Y.; Arakawa, K., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 297.
    摘要:Li, D.-D.; Wang, G.-W., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 355.
    摘要:Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie., 6B(183), 1951
    摘要:H. Vanderhaeghe and G. Derudder, Bull. Soc. Chim. Belg. 61, 310 (1952).
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知