专利号:WO-2024054881-A1 优先权日:2022-09-07 标题:Ligand-enabled scalable c-h hydroxylation of benzoic and phenylacetic acids at room temperature 发明人:YU JIN-QUAN; LI ZHEN; PARK HAN 权利人:SCRIPPS RESEARCH INST 摘要:The application discloses industry scalable methods of using bifunctional bidentate pyridone-carboxylic acid ligands, such as 2-methyl-2-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid, that enable room-temperature Pd-catalyzed C-H hydroxylation of a broad range of benzoic and phenylacetic acids with an industry-compatible oxidant, aqueous hydrogen peroxide, at room temperature. Further disclosed are methods of derivatization of the resulting hydroxylation products, synthesis of polyfluorinated natural products coumestan or pterocarpene from phenol building blocks, and hydroxylation of ibuprofen using this methodology,
专利号:US-8754197-B2 优先权日:2004-07-07 标题:Synthesis of azo bonded immunoregulatory compounds 发明人:RIGGS-SAUTHIER JENNIFER A; EKWURIBE NNOCHIRI N 权利人:RIGGS-SAUTHIER JENNIFER A; EKWURIBE NNOCHIRI N; BIOCON LTD 摘要:Methods are disclosed for preparing compounds of Formula I: n nwhere R 1 , R 3 , and R 4 are independently hydrogen or C 1 to C 4 alkyl, and R 2 is:n n nwhere R 5 is selected from the group consisting of hydrogen and C 1 to C 4 alkyl, orn n nwhere R 6 , R 7 and R 8 are independently hydrogen or C 1 to C 4 alkyl; or the esters or pharmacologically acceptable salts thereof. The compounds and or their metabolites can be used to treat or prevent various diseases, particularly inflammatory conditions of the GI tract.
专利号:US-10308595-B2 优先权日:2013-02-15 标 题:Albicidin derivatives, their use and synthesis 发明人:SUESSMUTH RODERICH; KRETZ JULIAN; SCHUBERT VIVIEN; PESIC ALEXANDER; HUEGELLAND MANUELA; ROYER MONIQUE; COCIANCICH STEPHANE; ROTT PHILIPPE; KERWAT DENNIS; GRAETZ STEFAN 权利人:UNIV BERLIN TECH 摘要:Antibiotically active compounds characterized by general formula (I), wherein X1, BB, BC, BD, BE and X2 are building blocks with D1, D2, D3, D4 or D5 being linkers which include carbon, sulphur, nitrogen, phosphor and/or oxygen atoms and which are covalently connecting the moities BA and BB, BB and BC, BC and BD, BD and BE and BE and BF, respectively, and wherein in particular the building block BC comprises an amino acid derivative. The compounds for use in a method of treatment of diseases, in particular for use in a method of treatment of bacterial infections are also disclosed.
专利号:US-2008033153-A1 优先权日:2004-07-07 标 题:Synthesis of Azo Bonded Immunoregulatory Compounds
专利号:US-7932366-B2 优先权日:2004-07-07 标 题 :Synthesis of azo bonded immunoregulatory compounds
专利号:US-8314214-B2 优先权日:2004-07-07 标 题:Synthesis of azo bonded immunoregulatory compounds
[参考文献]: Dhan Prakash, Et Al. Novel Pathway For The Degradation Of 2-Chloro-4-Nitrobenzoic Acid By Acinetobacter Sp. Strain Rkj12. Appl Environ Microbiol. 2011 Sep;77(18):6606-13.
合成参考文献
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