CAS: 655-20-9; 2-Fluorothioanisole

该化合物是一种有机化合物,其特征是,一种配有苯基细胞的硫醇(-SH)组,在正方形位置上进一步用氟原子替代.该化合物一般是一种无色的黄色黄色液体,有明显的气味,经常被描述为硫化或与大蒜相似,由硫醇功能组组成.它溶于有机溶剂,水溶液有限.氟素的存在可影响其反应性和极度,使其在有机合成和制药应用中成为有用的中间体.此外,2-氟苯甲卡普丹可能参与各种化学反应,包括核毒替代和混合反应,因为甲卡普坦组的再活性.在处理该化合物时,应当采取安全防范措施,因为硫素可能对皮肤和呼吸系统产生毒性和刺激.

英文名称2-Fluorothioanisole
中文名称2-氟苯甲醚
IUPAC名称(2-fluorophenyl)(methyl)sulfane
其它别名2-氟硫代苯甲醚; 2-Fluorophenyl Methyl Sulfide
CAS编号655-20-9
MFCD编号:MFCD03093762
EINECS号:624-207-6
分子式:C7H7FS
分子量:142.2
产品CID: 1637156
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: AYTSELVZWGHUEE-UHFFFAOYSA-N
InChI=1S/C7H7FS/c1-9-7-5-3-2-4-6(7)8/h2-5H,1H3…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
防范说明P210-P264-P280-P302+P352-P362+P364-P370+P378-P403-P501
危险等级IRRITANT, STENCH
UN编号NA 1993 / PGIII
危险品标志Xi
风险等级Irritant/Stench
安全声明26-36
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

Dimethyldisulphide o-potassiofluorobenzene Dithiopivalinsaeure-2-fluorphenylester 2-fluorothiophenol 1-Benzyl-4-(2-(methylthio)phenoxy)piperidine o-Fluorophenylthioglycolic acid 1-fluoro-2-(methylsulfinyl)benzene

合成工艺路线路线简述

2-溴茴香硫醚置于magnesium,Lithium Chloride,1-Fluoro-2,4,6-Trimethylpyridin-1-Ium Tetrafluoroborate体系中,用四氢呋喃,甲基九氟丁醚作为反应溶剂,化学反应生成 2-氟茴香硫醚
参考文献:芳基氟化物的高效合成
标题:芳基氟化物的高效合成
摘要:形成cf键:发现了芳基和杂芳基格氏试剂的新型亲电氟化,并用于有效合成各种芳基氟化物衍生物(参见图片; Thf =四氢呋喃).
DOI:10.1002/anie.200905855

海关参考信息

2930909099-其他有机硫化合物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2007238878-A1
优先权日:2004-10-13
标题 :Process for the synthesis of 4-(3-sulfonylphenyl)-piperidines
发明人：DESMOND RICHARD; DEVINE PAUL N; SONESSON CLAS; GAUTHIER DONALD R
权利人:DESMOND RICHARD; DEVINE PAUL N; SONESSON CLAS; GAUTHIER DONALD R
摘要:The present invention is directed to processes for the preparation of 4-(sulfonylphenyl)-piperidines of the Formula (VI), and pharmaceutically acceptable salts thereof; which comprises oxidizing a sulfide of the Formula (VII) or Formula (VIII), to give a compound of the Formula (IX) or Formula (X) respectively, followed by catalic reduction of the compound of the Formula (IX) or dehydration of compound of formula (X) to give a compound of Formula (IX) followed by catalytic reduction of the compound formula (IX) to give the compound of the Formula (VI).

专利号:US-12336981-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; DRAGOVICH Peter; GOSSELIN FRANCIS; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; ROTH BRUCE; SMITH CHASE C; WANG ZHONGGUO; YUEN PO-WAI; ZHENG XIAOZHANG
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below: