CAS: 6971-45-5; 2-Methoxyphenylhydrazine Hydrochloride

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CAS号90-04-0 邻氨基苯甲醚 | CAS号20442-97-1 2-Methoxyphenyl... | CAS号86-26-0 2-甲氧基联苯 | CAS号650628-19-6 5-amino-1-(2-me... | CAS号91331-85-0 2-(2-methoxyphe...

邻甲氧基苯胺置于盐酸,Sodium Nitrite,氯化亚砜体系中,用 水 作为反应溶剂,化学反应 1.0H,反应生成 2-甲氧基苯肼盐酸盐
参考文献:脱氢松香酸新的1,3,4-恶二嗪-5(6H)-One衍生物的合成,体外抗菌作用和细胞毒活性
标题:脱氢松香酸新的1,3,4-恶二嗪-5(6H)-One衍生物的合成,体外抗菌作用和细胞毒活性
摘要:设计并合成了一系列新的脱氢松香酸1,3,4-恶二嗪-5(6H)-One衍生物(6A-n)作为潜在的抗微生物剂和抗肿瘤剂.它们的结构通过ir,1 H NMR,13 C NMR,Ms和元素分析进行表征.使用连续稀释法评估所有标题化合物对四种细菌和三种真菌菌株的抗菌活性.其中,化合物6E对枯草芽孢杆菌具有最高的抗菌活性.最低抑菌浓度(mic)值为1.9μg/ Ml.此外,还通过mtt比色法对三种人类癌细胞系(mcf-7,Smmc-7772和hela)测定了标题化合物的体外细胞毒性活性.结果,化合物6B,6G,6K和6M表现出对至少一种ic 50值低于10μm的细胞系的显着抑制作用.特别发现化合物6M对mcf-7,Smmc-7721和hela细胞的ic 50值分别为2.26+/-0.23,0.97+/-0.11和1.89+/-0.31μm,是最有效的衍生物,与阳性对照依托泊苷相当.
DOI:10.1002/jccs.201700358

专利信息

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:US-9481685-B2
优先权日:2008-10-02
标 题:Imaging neuroinflammation
发明人：WADSWORTH HARRY JOHN; SHAN BO; O'SHEA DENNIS; PASSMORE JOANNA MARIE; TRIGG WILLIAM JOHN
权利人:WADSWORTH HARRY JOHN; SHAN BO; O'SHEA DENNIS; PASSMORE JOANNA MARIE; TRIGG WILLIAM JOHN; GE HEALTHCARE LTD
摘要:The present invention concerns in vivo imaging and in particular in vivo imaging of the peripheral benzodiazepine receptor (PBR). A tetracyclic indole in vivo imaging agent is provided that binds with high affinity to PBR, has good uptake into the brain following administration, and which preferentially binds to tissues expressing higher levels of PBR. The present invention also provides a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. A cassette for the automated synthesis of the in vivo imaging agent is also provided. In addition, the invention provides a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, as well as methods for the use of said in vivo imaging agent.

专利号:US-2019152896-A1
优先权日:2016-07-27
标题 :Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts

专利号:CN-114163351-B
优先权日:2020-09-11
标 题:Synthesis method of 2-(2-methoxy)phenylhydrazinecarboxylic acid methyl ester, an intermediate of oxamidone

专利号:US-8030311-B2
优先权日:2005-04-14
标题:Phenylacetamides suitable as protein kinase inhibitors
发明人：BOLD GUIDO; FURET PASCAL; GUAGNANO VITO; MCCARTHY CLIVE; VAUPEL ANDREA
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formula (I) wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof, as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases.

专利号:CN-104744311-B
优先权日:2015-04-20
标题:Synthesis method of bifenazate