专利号:US-9751851-B2 优先权日:2013-09-20 标 题:Molecules and compositions that inhibit gram negative bacteria and their uses 发明人:BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; CONRAD-MILLER LAURA C; O'LOUGHLIN COLLEEN T 权利人:UNIV PRINCETON; BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; MILLER LAURA C; O'LOUGHLIN COLLEEN T 摘要:Antivirulence strategies to combat Pseudomonas aeruginosa , are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.
专利号:CN-102898360-A 优先权日:2012-11-12 标题 :Synthesis of 3,5-Dibromo-4-fluoropyridine
专利号:CN-102898359-B 优先权日:2012-11-12 标题:Synthesis of 3,5-dibromo-4-iodopyridine
专利号:CN-102898359-A 优先权日:2012-11-12 标题:Synthesis of 3,5-dibromo-4-iodopyridine
专利号:CN-104530040-A 优先权日:2015-01-19 标 题 :A new method for the synthesis of 1,2,3-thiadiazole-5-carboxamidine compounds
专利号:US-5929082-A 优先权日:1995-03-24 标 题:Potassium ion channel blockers 发明人:CHAMBERS NOEL JOHN; JOHNSTON GRAHAM ALLEN ROSS 权利人:POLYCHIP PHARMACEUTICALS PTY; UNIV SYDNEY 摘要:PCT No. PCT/AU96/00151 Sec. 371 Date Jan. 23, 1998 Sec. 102(e) Date Jan. 23, 1998 PCT Filed Mar. 21, 1996 PCT Pub. No. WO96/30341 PCT Pub. Date Oct. 3, 1996The invention provides novel sulphonylurea, sulphonylthiourea and sulphonylguanidine compounds which have the ability to block potassium ion channels regulated by intracellular concentrations of ATP. Methods of synthesis, pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes, cardiac arrhythmias, ischaemic and hypoxic cardiovascular incidents, and cancers are also claimed.