156002-64-1 = 85064-61-5 反应条件:1.1 Reagents: Lithium Hydroxide Solvents: Tetrahydrofuran,Water; 90 Min,60 °C; 60 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified 标题:Synthesis And Activity Of Putative Small-Molecule Inhibitors Of The F-Box Protein Skp2* 作者:Shouksmith,Andrew E.; Evans,Laura E.; Tweddle,Deborah A.; Miller,Duncan C.; Willmore,Elaine; Et Al 参考文献:Australian Journal Of Chemistry 日期:2015 卷标:68(4) 页码:660-679
4-溴甲基四氢吡喃置于氢氧化钾,乙醇体系中,化学反应生成 四氢吡喃-4-乙酸 参考文献:Prelog Et Al.,Justus Liebigs Annalen Der Chemie,1937,Vol. 532,P. 80 标题:Prelog Et Al.,Justus Liebigs Annalen Der Chemie,1937,Vol. 532,P. 80
专利号:EP-1836163-B1 优先权日:2004-12-23 标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin 发明人:BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER 权利人:NOVARTIS AG 摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.
专利号:AU-646311-B2 优先权日:1990-10-17 标 题:Improved process for the synthesis of (4R-CIS)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-di oxane-4-acetate
专利号:US-2009270417-A1 优先权日:2006-06-13 标 题:Organic Compounds 发明人:MAIBAUM JUERGEN KLAUS; LORTHIOIS EDWIGE LILIANE JEANNE; BUEHIMAYER PETER 权利人:NOVARTIS AG 摘要:Novel 3,4-di-, 3,3,4-di-, 3,4,4,-tri- and 3,3,4,4-tetra-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula (I) wherein the substituents are as described in the specification.
专利号:US-8163773-B2 优先权日:2005-07-11 标题 :Organic compounds 发明人:BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI 权利人:BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI; NOVARTIS AG 摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The preferred compounds (which can also be present as salts) have the formula I wherein R1, R2, T, R3 and R4 are as defined in the specification.
专利号:RU-2117670-C1 优先权日:1988-10-31 标 题 :Derivatives of triazolo[1,4]diazepine and methods of their synthesis
专利号:JP-H03502798-A 优先权日:1988-02-22 标题:Improvement of trans-6-[2-(substituted pyrrol-1-yl)alkyl]pyran-2-one, an inhibitor of cholesterol synthesis
参考文献:10.1177/2472555219873068 摘要:Lee OW, Austin S, Gamma M, Cheff DM, Lee TD, Wilson KM, Johnson J, Travers J, Braisted JC, Guha R, Klumpp-Thomas C, Shen M, Hall MD. Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. SLAS Discov. 2020 Jan;25(1):9–20.