CAS: 942-06-3; 4,5-Dichlorophthalic Anhydride

该化合物是一种卤化衍生物,其特点是芳香环4和5个位置存在氯原子,该化合物是有机合成的多种中间体,特别是用于制备高性能染料,色素和聚酰胺树脂,其二氯替代会增强核循环替代和凝聚反应的再活性,使其对生产热稳定,耐化学的材料具有价值.

英文名称4,5-Dichlorophthalic Anhydride
中文名称5,6-二氯异苯并呋喃-1,3-二酮
IUPAC名称5,6-dichloroisobenzofuran-1,3-dione
其它别名4,5-二氯邻苯二甲酸酐; 4,5-Dichlorophthalic Anhydride
CAS编号942-06-3
MFCD编号:MFCD00075034
EINECS号:213-386-2
分子式:C8H2Cl2O3
分子量:217.01
产品CID: 1990284
产品分类有机原料→分子砌块→芳杂环类化合物→其它芳杂环类化合物

相似结构搜索
InChIKey: ULSOWUBMELTORB-UHFFFAOYSA-N
InChI=1S/C8H2Cl2O3/c9-5-1-3-4(2-6(5)10)8(12)13-7(3)11/h1-2H…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数0.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
严重眼刺激类别2
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi
安全声明26-37/39
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

合成目标产物 4,5-Dichlorophthalic Anhydride 主要起始原料 4,5-Dichlorophthalic Acid
56962-08-4 = 942-06-3
反应条件:1.1 Solvents: Acetyl Chloride; 2 H,Reflux
标题:Donor-Acceptor Complex Enables Alkoxyl Radical Generation For Metal-Free C(Sp3)-C(Sp3) Cleavage And Allylation/alkenylation
作者:Zhang,Jing; Li,Yang; Xu,Ruoyu; Chen,Yiyun
参考文献:Angewandte Chemie 日期:2017 卷标:56(41) 页码:12619-12623]

56962-08-4 = 942-06-3
反应条件:1.1 Catalysts: Niobium Pentoxide Solvents: O-Xylene; Rt -> 160 °C; 72 H,160 °C
标题:Heterogeneous Catalysts For The Cyclization Of Dicarboxylic Acids To Cyclic Anhydrides As Monomers For Bioplastic Production
作者:Rashed,N. Md.; Siddiki,S. M. A. H.; Ali,A. Md.; Moromi,Sondomoyee K.; Touchy,Abeda S.; Et Al
参考文献:Green Chemistry 日期:2017 卷标:19(14) 页码:3238-3242]

56962-08-4 = 942-06-3
反应条件:1.1 Solvents: Acetic Anhydride; Rt -> 110 °C; 1 H,110 °C -> 140 °C
标题:Preparation Method Of Octafluoro Substituted Phthalocyanine
参考文献:China]

56962-08-4 = 942-06-3
反应条件:1.1 Reagents: Acetic Anhydride
标题:Studies On The Chemistry Of Isoindoles And Isoindolenines. Xxvii. 3-Alkoxy-1H-Isoindoles: Syntheses And Properties
作者:Hennige,Hans; Kreher,Richard P.; Konrad,Michael; Jelitto,Frank
参考文献:Chemische Berichte 日期:1988 卷标:121(2) 页码:243-52]

56962-08-4 = 942-06-3
反应条件:1.1 Reagents: Acetic Anhydride; 1 H,Reflux
标题:Sarcosine Based Indandione Hglyt1 Inhibitors
作者:Thomson,Christopher G.; Duncan,Karen; Fletcher,Stephen R.; Huscroft,Ian T.; Pillai,Gopalan; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2006 卷标:16(5) 页码:1388-1391]

56962-08-4 = 942-06-3
反应条件:1.1 Reagents: Acetic Anhydride
标题:Novel Spirosuccinimides With Incorporated Isoindolone And Benzisothiazole 1,1-Dioxide Moieties As Aldose Reductase Inhibitors And Antihyperglycemic Agents
作者:Wrobel,Jay; Dietrich,Arlene; Woolson,Shiela A.; Millen,Jane; Mccaleb,Michael; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:1992 卷标:35(24) 页码:4613-27]

56962-08-4 = 942-06-3
反应条件:1.1 Reagents: Acetyl Chloride Solvents: Carbon Tetrachloride
标题:Synthesis Of New Pyridone Carboxylic Acid Derivatives As Potentially Therapeutic Chemicals
作者:Martinek,Peter
参考文献:1987]

56962-08-4 = 942-06-3
反应条件:1.1 Reagents: Acetic Anhydride; 3 H,140 °C; 140 °C -> Rt
标题:Organic Functionalized Non-Clustered Phthalocyanine Compounds,Their Preparation Method And Application As Solar Cell Materials
参考文献:China]

56962-08-4 = 942-06-3
反应条件:1.1 Reagents: Acetyl Chloride; 2 H,Reflux
标题:Synthesis And Biological Evaluation Of New Fluorinated And Chlorinated Indenoisoquinoline Topoisomerase I Poisons
作者:Beck,Daniel E.; Lv,Wei; Abdelmalak,Monica; Plescia,Caroline B.; Agama,Keli; Et Al
参考文献:Bioorganic & Medicinal Chemistry 日期:2016 卷标:24(7) 页码:1469-1479]

56962-08-4 = 942-06-3
反应条件:1.1 Reagents: Acetic Anhydride; 5 H,165 °C
标题:Discovery Of Novel Dual-Action Antidiabetic Agents That Inhibit Glycogen Phosphorylase And Activate Glucokinase
作者:Zhang,Lei; Chen,Xiaojie; Liu,Jun; Zhu,Qingzhang; Leng,Ying; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:2012 卷标:58 页码:624-639]

56962-08-4 = 942-06-3
反应条件:1.1 Solvents: Acetic Anhydride; Rt -> 100 °C; 12 H,100 °C
标题:Preparation Of Halogenated 1,3-Indanediones
参考文献:China]

56962-08-4 = 942-06-3
反应条件:1.1 Reagents: Acetic Anhydride; Rt -> 140 °C; 3 H,140 °C
标题:Synthesis Of 4,5-Dichlorophthalonitrile
作者:Wu,Yongfu; Sun,Gangchun; Li,Junhai; Wang,Shuzhao
参考文献:Huaxue Yu Shengwu Gongcheng 日期:2008 卷标:25(10) 页码:16-17]

56962-08-4 = 942-06-3
反应条件:1.1 Reagents: Acetic Anhydride; 2 H,Rt -> Reflux
标题:Tetrathiafulvalene Compound And Synthesis Method
参考文献:China]

56962-08-4 = 942-06-3
反应条件:1.1 Catalysts: Trifluoromethanesulfonic Acid Solvents: Toluene
标题:Process For Preparing Phthalic Anhydrides
参考文献:Japan]

89894-51-9 = 942-06-3
反应条件:1.1 Reagents: Carbon Solvents: 1,2,4-Trichlorobenzene
标题:Preparation Of Halogenated Phthalic Anhydrides
参考文献:United States]

89894-51-9 = 942-06-3
反应条件:1.1 Reagents: Carbon Solvents: 1,2,4-Trichlorobenzene
标题:Aromatization Of Halogenated Tetrahydrophthalic Anhydrides With Activated Carbon. An Effective Preparation Of 4,5-Dichlorophthalic Anhydride
作者:Fertel,Lawrence B.; Spohn,Ronald F.; O'Reilly,Neil J.; Lin,Henry C.
参考文献:Synlett 日期:1990 卷标:(9) 页码:539-40]

56962-08-4 = 942-06-3
反应条件:1.1 Reagents: Acetic Anhydride; 5 H,Rt -> Reflux
标题:Synthesis Of Water Soluble Pegylated (Copper) Phthalocyanines Via Mitsunobu Reaction And Cu(I)-Catalysed Azide-Alkyne Cycloaddition (Cuaac) "Click" Chemistry
作者:Li,Muxiu; Khoshdel,Ezat; Haddleton,David M.
参考文献:Polymer Chemistry 日期:2013 卷标:4(16) 页码:4405-4411]

= 942-06-3
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water
标题:Studies On Copper Phthalocyanine Pigments (I): Synthesis Of Chlorinated Phthalic Anhydrides And Their Reaction Velocity Rations In The Synthesis Of Chlorinated Copper Phthalocyanines
作者:Takesita,Masaaki
参考文献:Shikizai Kyokaishi 日期:1960 卷标:33(11) 页码:491-494]

56962-08-4 = 942-06-3
反应条件:1.1 Reagents: Acetic Anhydride
标题:Efficient Semitransparent Organic Solar Cells With Tunable Color Enabled By An Ultralow-Bandgap Nonfullerene Acceptor
作者:Cui,Yong; Yang,Chenyi; Yao,Huifeng; Zhu,Jie; Wang,Yuming; Et Al
参考文献:Advanced Materials (Weinheim 日期:2017 卷标:29(43)

邻苯二甲酸置于alkaline Solution,氯体系中,化学反应生成 4,5-二氯邻苯二甲酸酐
参考文献:Ruschtschinskii,Zhurnal Prikladnoi Khimii,1934,Vol. 7,P. 1113
标题:Ruschtschinskii,Zhurnal Prikladnoi Khimii,1934,Vol. 7,P. 1113

海关参考信息

2906210000-苄醇
2912110000-甲醛
2912210000-苯甲醛
2915110000-甲酸
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8017776-B2
优先权日:2003-07-15
标题 :Methods for synthesis of acyloxyalkyl compounds
发明人：BHAT LAXMINARAYAN; GALLOP MARK A
权利人:XENOPORT INC
摘要:Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

专利号:EP-2354120-A1
优先权日:2003-08-20
标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; YAO FENMEI; LUDWIKOW MARIA J; PHAN THU; PENG GE
权利人:XENOPORT INC
摘要:The present invention relates to acyloxyalkyl carbamate prodrugs of (Â±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (Â±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (Â±)-4-amino-3-(4-tluorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The present invention also relates to acyloxyalkyl carbamate prodrugs of (Â±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.

专利号:US-5436368-A
优先权日:1990-10-31
标题:Intermediates in the preparation of 4,5-difluoroanthranillic acid
发明人：BRAISH TAMIM F
权利人:PFIZER
摘要:Compounds of the formula ##STR1## which are intermediates in the preparation of 4,5-difluoroanthranilic acid, an intermediate itself in the synthesis of quinolone antibacterials, and methods of preparing these intermediates.

专利号:US-8372881-B2
优先权日:2005-06-20
标题 :Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
发明人：ZERANGUE NOA; JANDELEIT BERND; LI YUNXIAO; GALLOP MARK A
权利人:XENOPORT INC; ZERANGUE NOA; JANDELEIT BERND; LI YUNXIAO; GALLOP MARK A
摘要:Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl)-cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof to treat or prevent various diseases or disorders are disclosed. Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof suitable for oral and topical administration and for administration using sustained release dosage forms are also disclosed.

专利号:US-11472838-B2
优先权日:2018-04-17
标题:Inhibitors of blood coagulation factor XIII
发明人：HILS MARTIN; PASTERNACK RALF; BÃœCHOLD CHRISTIAN
权利人:ZEDIRA GMBH
摘要:The invention relates to a compound of general formula (I) as novel inhibitor of blood coagulation factor XIII, methods for synthesis thereof and to use thereof for the prophylaxis or treatment of diseases associated with blood coagulation factor XIII.

专利号:WO-9729091-A1
优先权日:1996-02-09
标题:Balanol analogues
发明人：NIELSEN JOHN; LYNGSOE LARS OLE
权利人:AUDA PHARMACEUTICALS APS; NIELSEN JOHN; LYNGSOE LARS OLE
摘要:The present invention relates to a solid phase methodology for the preparation of a combinatorial library of structural analogues of the natural product balanol (ophiocordin, azepinostatin), which is a protein kinase C (PKC) and protein kinase A (PKA) inhibitor. The method comprises solid-phase synthesis of the analog variants of balanol whereby a high molecular diversity is introduced. The synthetic scheme is based on a retrosynthetic analysis of the native structure which revealed three main building blocks suitable as templates for modification. The dicarboxy-functional moiety can be immobilised to the polymer support either as the monoallyl ester or as the internal anhydride. The libraries produced by the method are especially suited for high throughput screening of potential drug candidates for the treatment of mammals, especially humans.