CAS: 1187-58-2; N-Methylpropionamide

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CAS号74-89-5 氨基甲烷 | CAS号79-03-8 丙酰氯 | CAS号1719-57-9 氯甲基二甲基氯硅烷 | CAS号79-05-0 丙酰胺 | CAS号96-29-7 2-丁酮肟 | CAS号10341-59-0 (Z)-2-Butanone oxime | CAS号54509-73-8 ethene | CAS号85462-16-4 N-Methyl-O-p-ni... | CAS号71-23-8 正丙醇 | CAS号74-89-5 氨基甲烷 | CAS号627-35-0 N-甲基正丙胺 | CAS号32150-22-4 methyl N-methyl... | CAS号16395-80-5 N-methyl-N-nitr... | CAS号90910-85-3 zinc,N-methylpr...

氯甲基二甲基氯硅烷,丙酰胺置于六甲基二硅氮烷,Cesium Fluoride体系中,用 乙腈 用作溶剂,化学反应 48.0H,以82%的收率获得n-甲基丙酰胺
参考文献:使用氯甲基二甲基氯硅烷对酰胺和杂环进行化学选择性甲基化
标题:使用氯甲基二甲基氯硅烷对酰胺和杂环进行化学选择性甲基化
摘要:氯甲基二甲基甲硅烷基氯与酰胺的反应生成五配位的n-(氨基甲基)-卤代硅烷,其可以被氟化铯脱甲硅烷基化而得到n-甲基酰胺.这提供了在其他更多亲核基团存在下酰胺单烷基化的选择性方法.
Doi:10.1016/s0040-4039(00)00731-0

专利信息

专利号:US-6815214-B2
优先权日:2000-12-29
标 题 :Pharmaceutical uses and synthesis of diketopiperazines
发明人：BOYCE JIM P; HOWBERT J JEFFRY; TABONE JOHN C
权利人:CELLTECH R & D INC
摘要:The synthesis of novel diketopiperazines, their use in inhibiting cellular events such as those involving NFK-α, NFK-β and in the treatment of inflammation events, a combinatorial library of diverse diketopiperazines and process for their synthesis as a library and as individual compounds. In particular novel diketopiperazines are disclosed including their synthesis and use in cellular events such as activation of the transcription factor, nuclear factor, TNF-α, TNF-β and also apoptosis.

专利号:US-4898952-A
优先权日:1987-05-29
标 题 :Regioselective synthesis of a 1,5-disubstituted pyrazole
发明人：MURRAY WILLIAM V; WACHTER MICHAEL P
权利人:ORTHO PHARMA CORP
摘要:A highly regioselective synthesis of pyrazoles from a mono-substituted hydrazine and a beta -dicarbonyl compound wherein a carboxylic acid moiety is present on the substituent attached to one of the carbonyls. For example, compounds of the formula (I) are formed in marked preference to isomers of formula (IV): (I) (IV)

专利号:US-10882884-B2
优先权日:2016-05-18
标题:Stereoselective synthesis of phosphorothioate oligoribonucleotides
发明人：HALL JONATHAN; LI MEILING
权利人:ETH ZUERICH
摘要:The present invention relates to chiral phosphoramidites represented by formula (Ia) or formula (Ib) n n n n n n n n n n n n as novel monomers for the synthesis of stereodefined phosphorothioate MOE oligonucleotides. Furthermore, the present invention relates to a method for synthesizing stereodefined phosphorothioate MOE oligonucleotides using said novel chiral phosphoramidites.

专利号:WO-2024163644-A1
优先权日:2023-02-01
标题:Belt reactor manufacturing process for oligomer synthesis
发明人：KELLER KARSTEN; HILLEBRAND ROMAN
权利人:ARROWHEAD PHARMACEUTICALS INC
摘要:A method and apparatus for synthesis of oligomers such as oligonucleotides and peptides are disclosed. The method employs a device including at least one deprotection station to carry out a step of deprotection, at least one coupling station to carry out a step of coupling, optionally, one or more oxidation and/or thiolation stations to carry out a step of oxidation or thiolation, optionally, one or more capping stations to carry out a step of capping, and, optionally, one or more washing stations to carry out a step of washing. A plurality of solid phase material for oligomer synthesis is moved to the stations via a conveyor device, wherein a fluid delivery device acts upon said solid phase material to produce an oligomer.

专利号:US-6492136-B1
优先权日:1995-12-07
标题 :Solid phase organic synthesis
发明人：FLITSCH SABINE LAHJA; TURNER NICHOLAS JOHN
权利人:GENZYME LTD
摘要:A method of synthesis of a material corresponding to the general formula:characterized in that it comprises a material corresponding to the following general formula:being cleaved as indicated enzymatically or non-enzymatically using acid catalysis in the presence of a nucleophile, wherein: R1 represents a group providing the site for exo-enzyme or acid hydrolysis; R2 represents an intermediate linked to a solid support; R3 represents a carbohydrate, (oligo-)saccharide, (glyco-)peptide, (glyco-)lipid or an organic molecule which is at least one of heterocyclic and aromatic in structure; X represents O, N(H), N(R''), C(O)O, S, C(O)N(H) or C(O)N(R''), R'' being a non-interfering group; and Support represents a solid support.

专利号:US-7329760-B2
优先权日:2002-04-05
标题 :CC-1065 analog synthesis
发明人：ZHAO ROBERT YONGXIN; CHARI RAVI V J
权利人:IMMUNOGEN INC
摘要:Improved synthesis of seco(−)CBI (5-hydroxy-3-amino-1-[S]-(chloromethyl)-1,2-dihydro-3H-benz(e)indole): n nand improved syntheses therefrom of a wide variety of CC-1065 analogs that comprise a cyclopropabenzidole (CBI) alkylating moiety, and which are collectively DC1 and its derivatives, for the synthesis of cell-targeted therapeutic agents.