CAS: 1257-08-5; (2R,3R)-2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxychroman-3-Yl 3,4,5-Trihydroxybenzoate

该化合物是一种自然形成的花草甘油化合物,具有强效抗氧化特性,其主要优点包括增强自由的激进清扫能力,改进防氧化性压力的细胞防护. 这种化合物可能有助于寻求减轻氧化性损害和促进总体健康和福祉的应用.

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CAS号63604-98-8 3,5-bis(benzylo... | CAS号1486-48-2 3,4,5-三(苄氧基)苯甲酸 | CAS号1486-47-1 3,4,5-tris(phen... | CAS号20728-73-8 5,7,3',4'-四-O-苄基儿茶素 | CAS号87292-49-7 tetrabeuzyl-(-)... | CAS号87292-54-4 (2R)-2-[3,4-bis... | CAS号732298-08-7 (E)-3-[2,4-bis(... | CAS号732298-11-2 (+)-(1S,2S)-3-[... | CAS号108907-44-4 (-)-ecg-4''-o-me | CAS号1707-75-1 1,1-二苯基-2-苦味酰肼 | CAS号621-54-5 3-(3-羟基苯基)丙酸 | CAS号31129-95-0 5-(3-羟基苯基)戊酸 | CAS号31129-94-9 5-(3,4-dihydrox... | CAS号191666-22-5 2(3H)-Furanone,... | CAS号149-91-7 没食子酸; 3,4,5-三羟基苯甲酸 | CAS号490-46-0 表儿茶素(EC) | CAS号28543-07-9 茶黄素 3'-没食子酸酯 | CAS号6500-64-7 5-(3-甲氧基苯基)戊酸

合成工艺路线路线简述

    (2R,3S)-5,7-二(苄氧基)-2-[3,4-二(苄氧基)苯基]-3-色满醇置于palladium Dihydroxide 4-二甲氨基吡啶,氢气,L-Selectride,戴斯-马丁氧化剂体系中,用 四氢呋喃,甲醇,二氯甲烷 用作溶剂,化学反应 8.0H,反应生成(-)-表儿茶素没食子酸酯
    参考文献:Study Of The Green Tea Polyphenols Catechin-3-Gallate (Cg) And Epicatechin-3-Gallate (Ecg) As Proteasome Inhibitors
    标题:Study Of The Green Tea Polyphenols Catechin-3-Gallate (Cg) And Epicatechin-3-Gallate (Ecg) As Proteasome Inhibitors
    摘要:The Green Tea Polyphenol Catechin-3-Gallate (Cg) And Epicatechin-3-Gallate (Ecg) Were Synthesized Enantioselectively Via A Sharpless Hydroxylation Reaction Followed By A Diastereoselective Cyclization. Their Potencies To Inhibit The Proteasome Activity Were Measured. The Unnatural Enantiomers Were Found To Be Equally Potent To The Natural Compounds. (C) 2004 Elsevier Ltd,All Rights Reserved.
    Doi:10.1016/j.Bmc.2004.04.033

    海关参考信息

    专利信息


    专利号:US-2004266699-A1
    优先权日:2001-10-04
    标 题 :Flavonoid compounds capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells, relative synthesis and their use
    发明人:PORTA AMALIA
    摘要:The invention relates to flavonoids compounds of formula (I) and (II) capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells. Such compounds are molecules of plant origin or synthetic. The invention also describes a method to identify, purify and chemically synthesize such flavonoid compounds and test their efficacy through their capacity to stimulate the transcription of stress genes and as a consequence, to interact with biological membranes with alteration of their relative physical state. Such compounds and corresponding pharmaceutically acceptable derivatives and/or salts have applications in the areas of pharmaceuticals, more specifically in cosmetics and dermatology, for all those afections related to an alteration of the expression of stress genes.

    专利号:US-2006128930-A1
    优先权日:2004-12-03
    标题 :Synthesis of sterically hindered phenol based macromolecular antioxidants
    发明人:DHAWAN ASHISH; CHOLLI ASHOK L
    权利人:DHAWAN ASHISH; CHOLLI ASHOK L
    摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes polymerizing and alkylating a phenol containing monomer represented by the following structural formula: n n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.

    专利号:US-7678877-B2
    优先权日:2004-12-03
    标题 :Process for the synthesis of polyalkylphenol antioxidants
    发明人:YANG SUIZHOU; CHOLLI ASHOK L
    权利人:POLNOX CORP
    摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes partially etherifying, polymerizing and thermally rearranging a phenol containing monomer represented by the following structural formula: n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.

    专利号:US-10245558-B2
    优先权日:2011-09-09
    标 题 :Green synthesis nanocomposite membranes
    发明人:BHATTACHARYYA DIBAKAR; SMULEAC VASILE; VARMA RAJENDER S; SIKDAR SUBHAS K
    权利人:THE UNIV OF KENTUCKY RESEARCH FOUNDATION; US ENVIRONMENT
    摘要:A nanocomposite membrane includes a macroporous polymer membrane having a plurality of pores. A plurality of metal nanoparticles are synthesized and immobilized within those plurality of pores. The nanoparticles are reduced and capped with a green reducing and capping agent such as green tea extract.

    专利号:US-8143308-B2
    优先权日:2005-04-28
    标题 :Synthesis of oligo/poly(catechins) and methods of use
    发明人:BRUNO FERDINANDO F; KUMAR JAYANT; NAGARAJAN SUBHALAKSHMI; BRAUNHUT SUSAN J; NAGARAJAN RAMASWAMY; SAMUELSON LYNNE A; MCINTOSH DONNA; FOLEY KLAUDIA
    权利人:BRUNO FERDINANDO F; KUMAR JAYANT; NAGARAJAN SUBHALAKSHMI; BRAUNHUT SUSAN J; NAGARAJAN RAMASWAMY; SAMUELSON LYNNE A; MCINTOSH DONNA; FOLEY KLAUDIA; UNIV MASSACHUSETTS LOWELL; US ARMY
    摘要:A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.

    专利号:US-2014357576-A1
    优先权日:2013-05-31
    标题:Methods for enhancement of muscle protein synthesis
    发明人:BREUILLE DENIS; STELLINGWERFF TRENT; MOORE DANIEL RYAN; OFFORD CAVIN ELIZABETH ANN; PHILLIPS STUART MARTIN
    权利人:NESTEC SA
    摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis by enhancing myofibrillar muscle protein synthesis. The method includes administering to the individual a mixed macronutrient composition having (i) an amount of whey protein that is not capable of enhancing myofibrillar protein synthesis when ingested by itself and (ii) free leucine. The composition comprises at least about 5.0 g total leucine per dose.
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    主要参考文献


    1: Anderson JC, Grounds H, Reeves S, Taylor PW. Improved synthesis of structural analogues of (-)-epicatechin gallate for modulation of staphylococcal β-lactam resistance. Tetrahedron. 2014 May 27;70(21):3485-3490.

    合成参考文献


    参考文献:10.1007/s12192-011-0280-8
    摘要:Inoue H, Akiyama S, Maeda-Yamamoto M, Nesumi A, Tanaka T, Murakami A. High-dose green tea polyphenols induce nephrotoxicity in dextran sulfate sodium-induced colitis mice by down-regulation of antioxidant enzymes and heat-shock protein expressions. Cell Stress and Chaperones. 2011 Nov;16(6):653–62. doi: 10.1007/s12192-011-0280-8.
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