(2R,3S)-5,7-二(苄氧基)-2-[3,4-二(苄氧基)苯基]-3-色满醇置于palladium Dihydroxide 4-二甲氨基吡啶,氢气,L-Selectride,戴斯-马丁氧化剂体系中,用 四氢呋喃,甲醇,二氯甲烷 用作溶剂,化学反应 8.0H,反应生成(-)-表儿茶素没食子酸酯 参考文献:Study Of The Green Tea Polyphenols Catechin-3-Gallate (Cg) And Epicatechin-3-Gallate (Ecg) As Proteasome Inhibitors 标题:Study Of The Green Tea Polyphenols Catechin-3-Gallate (Cg) And Epicatechin-3-Gallate (Ecg) As Proteasome Inhibitors 摘要:The Green Tea Polyphenol Catechin-3-Gallate (Cg) And Epicatechin-3-Gallate (Ecg) Were Synthesized Enantioselectively Via A Sharpless Hydroxylation Reaction Followed By A Diastereoselective Cyclization. Their Potencies To Inhibit The Proteasome Activity Were Measured. The Unnatural Enantiomers Were Found To Be Equally Potent To The Natural Compounds. (C) 2004 Elsevier Ltd,All Rights Reserved. Doi:10.1016/j.Bmc.2004.04.033
专利号:US-2004266699-A1 优先权日:2001-10-04 标 题 :Flavonoid compounds capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells, relative synthesis and their use 发明人:PORTA AMALIA 摘要:The invention relates to flavonoids compounds of formula (I) and (II) capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells. Such compounds are molecules of plant origin or synthetic. The invention also describes a method to identify, purify and chemically synthesize such flavonoid compounds and test their efficacy through their capacity to stimulate the transcription of stress genes and as a consequence, to interact with biological membranes with alteration of their relative physical state. Such compounds and corresponding pharmaceutically acceptable derivatives and/or salts have applications in the areas of pharmaceuticals, more specifically in cosmetics and dermatology, for all those afections related to an alteration of the expression of stress genes.
专利号:US-2006128930-A1 优先权日:2004-12-03 标题 :Synthesis of sterically hindered phenol based macromolecular antioxidants 发明人:DHAWAN ASHISH; CHOLLI ASHOK L 权利人:DHAWAN ASHISH; CHOLLI ASHOK L 摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes polymerizing and alkylating a phenol containing monomer represented by the following structural formula: n n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.
专利号:US-7678877-B2 优先权日:2004-12-03 标题 :Process for the synthesis of polyalkylphenol antioxidants 发明人:YANG SUIZHOU; CHOLLI ASHOK L 权利人:POLNOX CORP 摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes partially etherifying, polymerizing and thermally rearranging a phenol containing monomer represented by the following structural formula: n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.
专利号:US-10245558-B2 优先权日:2011-09-09 标 题 :Green synthesis nanocomposite membranes 发明人:BHATTACHARYYA DIBAKAR; SMULEAC VASILE; VARMA RAJENDER S; SIKDAR SUBHAS K 权利人:THE UNIV OF KENTUCKY RESEARCH FOUNDATION; US ENVIRONMENT 摘要:A nanocomposite membrane includes a macroporous polymer membrane having a plurality of pores. A plurality of metal nanoparticles are synthesized and immobilized within those plurality of pores. The nanoparticles are reduced and capped with a green reducing and capping agent such as green tea extract.
专利号:US-8143308-B2 优先权日:2005-04-28 标题 :Synthesis of oligo/poly(catechins) and methods of use 发明人:BRUNO FERDINANDO F; KUMAR JAYANT; NAGARAJAN SUBHALAKSHMI; BRAUNHUT SUSAN J; NAGARAJAN RAMASWAMY; SAMUELSON LYNNE A; MCINTOSH DONNA; FOLEY KLAUDIA 权利人:BRUNO FERDINANDO F; KUMAR JAYANT; NAGARAJAN SUBHALAKSHMI; BRAUNHUT SUSAN J; NAGARAJAN RAMASWAMY; SAMUELSON LYNNE A; MCINTOSH DONNA; FOLEY KLAUDIA; UNIV MASSACHUSETTS LOWELL; US ARMY 摘要:A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.
专利号:US-2014357576-A1 优先权日:2013-05-31 标题:Methods for enhancement of muscle protein synthesis 发明人:BREUILLE DENIS; STELLINGWERFF TRENT; MOORE DANIEL RYAN; OFFORD CAVIN ELIZABETH ANN; PHILLIPS STUART MARTIN 权利人:NESTEC SA 摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis by enhancing myofibrillar muscle protein synthesis. The method includes administering to the individual a mixed macronutrient composition having (i) an amount of whey protein that is not capable of enhancing myofibrillar protein synthesis when ingested by itself and (ii) free leucine. The composition comprises at least about 5.0 g total leucine per dose.
1: Anderson JC, Grounds H, Reeves S, Taylor PW. Improved synthesis of structural analogues of (-)-epicatechin gallate for modulation of staphylococcal β-lactam resistance. Tetrahedron. 2014 May 27;70(21):3485-3490.
合成参考文献
参考文献:10.1007/s12192-011-0280-8 摘要:Inoue H, Akiyama S, Maeda-Yamamoto M, Nesumi A, Tanaka T, Murakami A. High-dose green tea polyphenols induce nephrotoxicity in dextran sulfate sodium-induced colitis mice by down-regulation of antioxidant enzymes and heat-shock protein expressions. Cell Stress and Chaperones. 2011 Nov;16(6):653–62. doi: 10.1007/s12192-011-0280-8.