CAS: 2529-45-5; (8S,9R,10S,11S,13S,14S,17R)-17-Acetyl-9-Fluoro-11-Hydroxy-10,13-Dimethyl-3-Oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-17-Yl Acetate

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CAS号24320-12-5 17-acetoxy-9,11... | CAS号24320-15-8 9-Bromo-11beta,...

氟氢可的松置于sodium Dithionite,三乙胺,对甲苯磺酰氯,Sodium Iodide体系中,用 乙醇,二氯甲烷,氯仿,水,甲苯 用作溶剂,化学反应生成氟孕酮醋酸酯
参考文献:醋酸氟孕酮的制备方法
标题:醋酸氟孕酮的制备方法
摘要:醋酸氟孕酮的制备方法,以9A‑氟氢化可的松为原料,将其溶解于有机溶剂中,在缚酸剂存在下与酰氯反应,得9A氟‑氢化可的松‑21‑o‑酯化物;再将该酯化物在有机溶剂中与碘化钠和含硫还原剂反应脱酯化,合成氟孕酮;最后将该氟孕酮在有机溶剂中与乙酰氯或乙酸酐反应,合成醋酸氟孕酮.本发明采用9A‑氟氢化可的松为原料,通过21位酯化,再还原脱酯化,最后17位乙酯化三步反应合成醋酸氟孕酮,相对以薯蓣皂素加工获得的霉脱物作原料的传统合成方法,具有原料来源广泛,合成路线短,工艺简便环保,投入设备少,产品收率高等诸多优点,本法生产成本比传统方法降低25‑30%;生产中使用的溶剂可回收循环套用,易于实施工业化生产.

专利信息

专利号:EP-2641591-A1
优先权日:2012-03-20
标 题:Synthesis of Starch Based Bioadhesive Polymers and Applications in Drug Carrier Systems

专利号:US-5902603-A
优先权日:1995-09-14
标题 :Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use
发明人：CHEN TUNG-FEN; CHIANG CHIA-MING; JONA JANAN; JOSHI PRITI; RAMDAS ASHA
权利人:CYGNUS THERAPEUTIC SYSTEMS
摘要:High capacity drug reservoirs are provided for incorporation into transdermal drug delivery systems. The drug reservoirs are hydrogels formulated from polyurethanes crosslinked with diisocyanate crosslinking agents or cured with radiation in the presence of a photoinitator. Drug loading as high as 65 to 70 wt. % or higher can be achieved by absorbing drug formulation into the reservoir after hydrogel synthesis. Methods for making and using transdermal systems containing such reservoirs are provided as well.

专利号:WO-2020141509-A1
优先权日:2018-12-31
标 题 :Compositions and methods for inhibiting ovulation
发明人：HOURVITZ ARIEL; YUNG YUVAL; YERUSHALMI GIL; SHURAKI BAT-EL
权利人:HOURVITZ ARIEL; YUNG YUVAL; YERUSHALMI GIL; SHURAKI BAT EL
摘要:Compositions, methods and kits for inhibiting ovulation in a female subject are provided, which utilize inhibitors of the prostaglandin E2 transporter ABCC4, alone or in combination with inhibitors of prostaglandin synthesis.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:EP-0907359-B1
优先权日:1995-09-14
标 题 :Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems
发明人：CHEN TUNG-FEN; CHIANG CHIA-MING; JONA JANAN; JOSHI PRITI; RAMDAS ASHA
权利人:ORTHO MCNEIL PHARM INC
摘要:High capacity drug reservoirs are provided for incorporation into transdermal drug delivery systems. The drug reservoirs are hydrogels formulated from polyurethanes crosslinked with diisocyanate crosslinking agents or cured with radiation in the presence of a photoinitiator. Drug loading as high as 65 to 70 wt.% or higher can be achieved by absorbing drug formulation into the reservoir after hydrogel synthesis. Methods for making and using transdermal systems containing such reservoirs are provided as well.