CAS: 3534-50-7; 3,5,6-Trifluoropyridin-2-Amine

相似化合物

944799-22-8 189281-25-2 179064-72-3

上下游产品

CAS号851179-05-0 (3,5,6-trifluor... | CAS号2875-18-5 2,3,5,6-四氟吡啶 | CAS号3512-12-7 2-AMINO-4-BROMO... | CAS号3511-90-8 4-溴-2,3,5,6-四氟吡啶

2,3,5,6-四氟吡啶置于氨体系中,化学反应 5.0H,以78%的收率获得2-氨基-3,5,6-三氟吡啶
参考文献:多氟苯和吡啶与液氨的选择性单和二胺化
标题:多氟苯和吡啶与液氨的选择性单和二胺化
摘要:五氟吡啶,2,3,5,6-四氟吡啶,4-氯四氟吡啶,3,5-二氯三氟吡啶,八氟甲苯,α,α,α,2,3,5,6-七氟甲苯,十氟间二甲苯,十氟联苯的胺化,六氟苯和五氟苯与液氨进行了研究.大多数底物的双氨基脱氟化温度显着超过单氨基脱氟化的相应温度.阐明了选择性制备单和二氨基多氟(杂)芳烃的最佳条件.提出了一种从五氟苯和六氟苯与氨水基于与冠醚络合的非选择性反应中形成的产物混合物中分离特定多氟苯二胺的有效方法.
Doi:10.1007/s11172-007-0351-2

专利信息

专利号:US-6136823-A
优先权日:1996-11-28
标题 :Pyridonecarboxylic acid derivatives or salts thereof and drugs containing the same as the active ingredient
发明人：SAKAE NOBUYA; YAZAKI AKIRA; KURAMOTO YASUHIRO; YOSHIDA JIRO; NIINO YOSHIKO; OHSHITA YOSHIHIRO; HIRAO YUZO; HAYASHI NORIHIRO; AMANO HIROTAKA
权利人:WAKUNAGA PHARMA CO LTD
摘要:PCT No. PCT/JP97/04326 Sec. 371 Date May 28, 1999 Sec. 102(e) Date May 28, 1999 PCT Filed Nov. 27, 1997 PCT Pub. No. WO98/23592 PCT Pub. Date Jun. 4, 1998The invention relates to pyridonecarboxylic acid derivatives represented by the general formula (1): wherein R1 is -OH, a carboxy-protecting group or (alkyl)amino group, R2 is H, or -NO2, (protected) amino, (protected) hydroxyl, lower alkyl or lower alkoxyl group, R3 is a halogen atom, H, or -NO2, lower alkyl, lower alkoxyl or amino group, R4 is an azido, (substituted) hydrazino, (substituted) amino, lower alkoxyl or hydroxyl group, R5, R6 and R7 are independently H, -NO2, halogen atom or lower alkyl group, R8 is a -NO2, (substituted) amino, -OH or lower alkoxyl group, A is N or C-R12, in which R12 is H, halogen atom, or (substituted) lower alkyl, lower alkenyl, lower alkynyl, lower alkoxyl, lower alkylthio or nitro group, and B is N or C-R13, in which R13 is H or halogen atom, or salts thereof, and medicine comprising such a compound as an active ingredient. The derivatives or the salts thereof exhibit excellent antibacterial action and peroral absorbability, scarcely cause side effects, and are easy of synthesis.