CAS: 583-60-8; 2-Methylcyclohexanone

相似化合物

22554-29-6 583-59-5 19043-03-9

上下游产品

Diazoethan diethyl ether cyclopentanone 1-(1-Cyclohexen-1-yl)pyrrolidine 6-methyl-1-pyrrolidino-1-cyclohexene 2,2'-dimethyl-2,2'-methanediyl-bis-cyclohexanone (+/-)-2-((Ξ)-furfurylidene)-6-methyl-cyclohexanone (+/-)-2-methyl-6-((Ξ)-[2]thienylmethylene)-cyclohexanone Ketones ( 2-nitr°Cinnamic aldehyde quinoline benzyl potassium benzyl alcohol 1-(1-methylethyl)-1,2,3,4-tetrahydroquinoline Thiazole-4-carboxylic acid (1,2,3,4-tetrahydro-quinolin-6-yl)-ethenetricarbonitrile quinoline

1-甲基-2-氧代环己烷甲酸烯丙酯置于bis-Triphenylphosphine-Palladium(II) Chloride Ammonium Formate体系中,用 1,4-二氧六环 作为反应溶剂,以87%的收率获得产物2-甲基环己酮
参考文献:Palladium-Catalyzed Decarboxylation-Dehydrogenation Of Allyl .Beta.-Oxo Carboxylates And Allyl Enol Carbonates As A Novel Synthetic Method For .Alpha.-Substituted .Alpha.,.Beta.-Unsaturated Ketones
标题:Palladium-Catalyzed Decarboxylation-Dehydrogenation Of Allyl .Beta.-Oxo Carboxylates And Allyl Enol Carbonates As A Novel Synthetic Method For .Alpha.-Substituted .Alpha.,.Beta.-Unsaturated Ketones
摘要:
DOI:10.1021/ja00385A075

专利信息

专利号:US-9388131-B2
优先权日:2011-04-27
标题:Automated synthesis of small molecules using chiral, non-racemic boronates
发明人：BURKE MARTIN D; LI JUNQI; GILLIS ERIC P
权利人:UNIV ILLINOIS
摘要:Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.

专利号:US-11708363-B2
优先权日:2020-09-30
标 题:Method for preparing a key intermediate for the synthesis of statins
发明人：CHEN FENER; CHENG DANG; LIU MINJIE; HUANG ZEDU; TAO YUAN; WANG JIAQI
权利人:UNIV FUDAN
摘要:Disclosed herein relates to organic synthesis, and more particularly to a method for preparing a key intermediate for the synthesis of statins. The key intermediate is 2-[(4R,6S)-6-[(benzo[d]thiazol-2-ylthio)methyl]-2,2-disubstituted-1,3-dioxan-4-yl] acetate of formula (I): n nwhere R 1 is a C 1 -C 8 alkyl group, a C 3 -C 8 cycloalkyl group, a monosubstituted or polysubstituted aryl group, or monosubstituted or polysubstituted aralkyl group; R 2 is hydrogen, or monosubstituted or polysubstituted C 1 -C 3 alkyl group, or halogen; and R 3 and R 4 are each independently a C 1 -C 5 alkyl group, a C 3 -C 7 cycloalkyl group, a C 3 -C 7 cycloalkenyl group, a C 1 -C 3 alkoxy group, a C 6 -C 10 aryl group, or C 7 -C 12 aralkyl group. In the method, a halomethyl compound and a thiol reagent are subjected to nucleophilic substitution in an organic solvent to synthesize a thioether, which then undergoes ketal exchange reaction with a carbonyl compound (V) in the presence of an organic acid to obtain a target product.

专利号:US-6133018-A
优先权日:1997-06-02
标 题 :Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE L; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:US-2006211858-A1
优先权日:2001-02-28
标 题 :Novel substituted calix (4) pyrroles and process for the synthesis of calix (4) pyrroles over molecular sieve catalysts
发明人：RAGHAVAN KONDAPURAM V; KULKARNI SHIVANAND J; KISHAN MOTKURI R; SRINIVAS NAGABANDI
权利人:RAGHAVAN KONDAPURAM V; KULKARNI SHIVANAND J; KISHAN MOTKURI R; SRINIVAS NAGABANDI
摘要:The present invention relates to novel calix pyrroles and a process for synthesis of calix (4) pyrroles by reacting pyrrole with cyclic or acyclic ketones in dichloro methane (DCM) solvent over molecular sieve catalysts which provides an eco-friendly, more economical and selective heterogeneous method.

专利号:US-4239689-A
优先权日:1978-12-18
标题 :Total synthesis of the utero-evacuant substance d,l-zoapatanol
发明人：KANE VINAYAK V
权利人:ORTHO PHARMA CORP
摘要:A method for the synthesis of racemic 2S*, 3R*-6E-(2'-hydroxyethylidene)-2-methyl-2-(4',8'-dimethyl-5'-oxo-7'-nonenyl)-oxepan-3-ol is described. The naturally occurring product, 2S, 3R-6E-(2'-hydroxyethylidene)-2-methyl-2-(4',8'-dimethyl-5'-oxo-7'-nonenyl)-oxepan-3-ol, is one of the active components of the zoapatle plant.

专利号:US-4219489-A
优先权日:1978-09-05
标题:Synthesis of steroids
发明人：BUNES LEONARD A; JOHNSON WILLIAM S
权利人:STANFORD LELAND JUNIOR UNIV TR
摘要:Method and compounds are provided for use in the synthesis of steroids wherein a polyolefin is provided having an initiating group having a chalcogen atom in juxtaposition to a double bond, so as to be capable of bond formation to close to form a ring and having a terminating group involving pi unsaturation (a double or triple bond) conjugated to an aromatic ring. Upon acid catalysis, sigma bonds are formed through the interaction of a carbocation formed at the carbon atom bonded to the chalcogen atom and the double bond intermediate the initiating group and the terminating group, which close to form rings of a steroid nucleus, the carbocation interacting with the pi unsaturation conjugated with the aromatic group and being captured by a nucleophile present in the acidic reaction medium. The resulting steroid product may then be modified in known ways to produce known steroids.