专利号:US-3992439-A 优先权日:1972-04-17 标 题:Synthesis of prostaglandins of the 'one'-series 发明人:SCHAAF THOMAS K; COREY ELIAS J 权利人:PFIZER 摘要:In the synthesis of prostaglandins of the 'one' -series an alteration in the conventional reaction sequence avoids side reactions and provides an improved synthesis via a series of novel intermediates. In this improved synthesis the side chain at the 8 position is attached to the five membered ring before the side chain at the 12 position is attached.
专利号:US-2023183177-A1 优先权日:2020-04-24 标题:Enantioselective chemo-enzymatic synthesis of optically active amino amide compounds 发明人:GRILL BIRGIT; WINKLER MARGIT; SCHWAB HELMUT; STROHMEIER GERNOT; DONSBACH KAI; WALDVOGEL SIEGFRIED R; ARNDT SEBASTIAN; WEIS DOMINIK 权利人:PHARMAZELL GMBH 摘要:The present invention relates to a novel biocatalytic process for the stereoselective preparation of alpha amino amide compounds catalyzed by NHase enzymes. A further aspect of the invention relates to novel NHase enzymes as well as further improved NHase enzyme mutants, nucleic acid molecules encoding these enzymes, recombinant microorganisms suitable for preparing such enzymes and mutants. Another aspect of the invention relates to a chemo-biocatalytic process for the preparation of lactam compounds comprising the new catalytic process for the preparation of alpha amino amide compounds catalyzed by NHase enzymes, as well as the chemical oxidation of the alpha amino amide by applying certain chemical oxidation catalysts suitable for converting the alpha amino amide under retention of its stereochemical configuration to the respective lactam. The novel chemo-biocatalytic process is particularly suited for the synthesis of valuable pharmaceutical compounds, like in particular (S)-Levetiracetam.
专利号:US-2025171411-A1 优先权日:2022-03-01 标题:Synthesis of 5-acetoxymethyl furfural in the presence of recyclable salt catalysts 发明人:MELLER ELAD; LEADER AVIA 权利人:CELLUFLUX LTD 摘要:A process for preparing and ester of 5-hydroxymethyl furfural of the formula: (I) wherein R is a linear or branched alkyl or alkenyl, comprising adding to a reaction vessel Ce carbohydrate, organic acid R—COOH and a salt which is at most sparingly soluble in said organic acid to form a reaction mass, heating the reaction mass, allowing the reaction to proceed, separating the salt from the liquid phase and recovering a reaction product comprising an ester of 5-hydroxymethyl furfural.
专利号:US-6235944-B1 优先权日:1999-01-21 标 题:Production of secondaryalkoxy-1-alkenes 发明人:JOHN THOMAS V; SUBRAMANIAM CHITOOR S; WANG ZHENG; KUCERA JR RICHARD J 权利人:CREANOVA INC 摘要:The present invention relates to a general synthesis for producing secondaryalkoxy-1-alkenes in commercial quantities in good yields by reacting cyclic and acyclic ketones and the corresponding alcohol with a secondary alkyl orthoformate ester in the presence of an acid catalyst, a Lewis acid, ferric chloride being preferred, and recovering the produce as a liquid of high purity.
专利号:WO-2023166503-A1 优先权日:2022-03-01 标 题:Synthesis of 5-acetoxymethyl furfural in the presence of recyclable salt catalysts
专利号:WO-2021214283-A1 优先权日:2020-04-24 标题 :Enantioselective chemo-enzymatic synthesis of optically active amino amide compounds
摘要:S104 | UKVETMED | UK Veterinary Medicines Directorate's List | DOI:10.5281/zenodo.7802119 摘要:Merck Index - O'Neil MJ, Heckelman PE, Dobbelaar PH, Roman KJ (eds). The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, 15th Ed. Cambridge, UK: The Royal Society of Chemistry, 2013. 摘要:Comptes Rendus Hebdomadaires des Seances, Academie des Sciences., 257(791), 1963