CAS: 106-21-8; 3,7-Dimethyloctan-1-Ol

该化合物是一种分链脂肪酒精,其特征为长碳氢化合物链和位于第3和第7碳位置的两个甲基组;该化合物是一种无色的淡黄色液体,具有典型的气味,通常用于生产表面活性剂,润滑剂和食品工业的调味剂;其分子式为C10H22O,表明它含有10个碳原子,22个氢原子和1个氢氧xyl组;氢氧基化合物的存在有助于其在有机溶剂中的溶解性,同时使其在水中溶解性较低.3,7-二甲基-1-辛醇的挥发性较轻,与更大的酒精相比,沸点相对较低.必须谨慎处理这一物质,因为它可能会对皮肤和接触的眼产生刺激.此外,它被归类为易燃液体,需要适当的储存和处理程序来减轻火灾危害.

结构式图片

相似化合物

68680-98-8 1117-60-8 645-72-7

欧盟法规

REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号5392-40-5 柠檬醛 | CAS号624-15-7 3,7-二甲基-2,6-辛二烯-1-醇 | CAS号106-22-9 香茅醇 | CAS号106-24-1 香叶醇; (E)-3,7-二甲... | CAS号106-23-0 香茅醛 | CAS号2270-60-2 3,7-二甲基-6-辛烯酸甲酯 | CAS号52188-73-5 3,7-dimethyl°Ct... | CAS号342621-47-0 1-tert-butyldim... | CAS号124186-79-4 1-iodo-3,7-dime... | CAS号3681-74-1 3,7-dimethyl°Ct... | CAS号72962-76-6 6,10-dimethylun... | CAS号7540-70-7 4,6-dimethylnon... | CAS号68680-98-8 (S)-3,7-二甲基辛烷-1-醇 | CAS号816463-62-4 1,2-bis(3,7-dim... | CAS号93804-81-0 3,7-dimethyl°Ct... | CAS号55067-07-7 3,7-dimethyl°Ct...

合成工艺路线路线简述

    四氢-4-甲基-2H-吡喃置于氢氧化钾,Dilithium Tetrachlorocuprate,Magnesium,Zinc(II) Chloride体系中,化学反应 19.5H,反应生成二甲基-1-辛醇
    参考文献:Synthesis Of Ethyl 3,7,11-Trimethyl-2,4-Dodecadienoate (Hydroprene) From 4-Methyltetrahydropyran
    标题:Synthesis Of Ethyl 3,7,11-Trimethyl-2,4-Dodecadienoate (Hydroprene) From 4-Methyltetrahydropyran
    摘要:
    Doi:10.1007/bf00956974

    海关参考信息

    专利信息


    专利号:US-4125735-A
    优先权日:1975-03-20
    标 题 :Synthesis of esters of acetylenic alcohols
    发明人:CLOSE RALPH E; OROSHNIK WILLIAM
    权利人:SCM CORP
    摘要:A process for the synthesis of perfume products, Vitamin E and intermediates described herein involving a coupling reaction. For instance, a process for the synthesis of dehydrophytol and Vitamin E comprising forming a C15 acetylene from hexahydropseudoionone and then coupling said acetylene with 1-acetoxy-4-chloro-3-methylbut-2-ene to form a C20 acetoxy-enyne. The latter is readily subjected to partial hydrogenation and saponification in that order to form a dehydrophytol, a useful intermediate for the synthesis of Vitamin E and other products.

    专利号:US-4039591-A
    优先权日:1975-03-20
    标 题:Synthesis of dehydrophytol and Vitamin E
    发明人:CLOSE RALPH E; OROSHNIK WILLIAM
    权利人:SCM CORP
    摘要:A process for the synthesis of dehydrophytol and Vitamin E comprising forming a C15 acetylene from hexahydropseudoionone and then coupling said acetylene with 1-acetoxy-4-chloro-3-methylbut-2-ene to form a C20 acetoxy-enyne. The latter is readily subjected to partial hydrogenation and saponification in that order to form a dehydrophytol, a useful intermediate for the synthesis of Vitamin E and other products.

    专利号:US-4115466-A
    优先权日:1975-10-16
    标题:Synthesis of acetylenic compounds useful in preparing dehydrophytols and Vitamin E
    发明人:CLOSE RALPH E; OROSHNIK WILLIAM
    权利人:SCM CORP
    摘要:A process for the synthesis of an acetylenic hydrocarbon from an acetylenic carbinol which involves first replacing the hydroxyl group of the carbinol with a halogen to form a propargylic halide, dehalogenating the propargylic halide to form an allene, and isomerizing said allene to the desired acetylene. The present invention is particularly useful in the synthesis of Vitamin E.

    专利号:US-4056573-A
    优先权日:1975-04-24
    标题:Synthesis of acyclic, terpene alcohols
    发明人:CLOSE RALPH E; DERFER JOHN M
    权利人:SCM CORP
    摘要:Shown is a process for the synthesis of acyclic, terpene alcohols, such as 3,7-dimethyloctan-1-o1 and 7-substituted hydroxy or ethoxy derivatives thereof, wherein 3-methylbut-1-yn or the 3-substituted hydroxy or ether derivative thereof is coupled with a C5 coupling reagent having the configuration X being a leaving group such as chloride, bromide, iodide, tosylate and mesylate; R being or OR', R' being a lower alkyl up to 5 carbon atoms, phenyl, substituted phenyl up to 10 carbon atoms, cycloalkyl or aralkyl up to 10 carbon atoms, followed by hydrogenation and saponification or deetherification.

    专利号:US-4518813-A
    优先权日:1981-10-02
    标 题:Optically active units for the synthesis of the side chain of (R,R,R)-α-tocopherol and their preparation
    发明人:ERNST HANSGEORG; VOGEL FRIEDRICH; PAUST JOACHIM
    权利人:BASF AG
    摘要:(2R,6R)-1-Chloro-2,6,10-trimethyl-undecane I, (R)-(+)-β-chloro-isobutyric acid II, (S)-(+)-1-bromo-3-chloro-2-methylpropane IV and (2R)-(+)-1-chloro-2,6-dimethyl-heptane V are novel optically active units for the synthesis of the side chain of (R,R,R)-α-tocopherol. In the process according to the invention, the optically active C 14 -chloride I is obtained in 6 simple reaction steps starting from II, via the novel intermediates IV and V, in accordance with the following equation: ##STR1##

    专利号:US-2007082039-A1
    优先权日:2004-10-18
    标题 :Synthesis of fatty alcohol esters of alpha-hydroxy carboxylic acids, the use of the same as percutaneous permeation enhancers, and topical gels for the transdermal delivery of steroids
    发明人:JONES GERALD S JR; ST LAURENT JOSEPH P; GOODRICH SCOTT A
    权利人:JONES GERALD S JR; ST LAURENT JOSEPH P; GOODRICH SCOTT A
    摘要:The present invention provides a novel approach for the preparation of fatty alcohol esters of α-hydroxy carboxylic acids. The present invention also provides a novel topical gel for the transdermal delivery of steroids using the fatty alcohol esters as permeation enhancers.
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    主要参考文献

    [参考文献]: A Lapczynski, Et Al. Fragrance Material Review On 3,7-Dimethyl-1-Octanol. Food Chem Toxicol. 2008 Nov:46 Suppl 11:S139-41.
    [参考文献]: J Harder, Et Al. Microbial Degradation Of Monoterpenes In The Absence Of Molecular Oxygen. Appl Environ Microbiol. 1995 Nov;61(11):3804-8.
    [参考文献]: J Pevsner, Et Al. Odorant-Binding Protein. Characterization Of Ligand Binding. J Biol Chem. 1990 Apr 15;265(11):6118-25.
    [参考文献]: Mineo Ikematsu, Et Al. Odorant Binding Initially Occurring At The Central Pocket In Bovine Odorant-Binding Protein. Biochem Biophys Res Commun. 2005 Aug 12;333(4):1227-33.
    [参考文献]: R M Hanif, Et Al. Penetration Enhancing Effect Of Tetrahydrogeraniol On The Percutaneous Absorption Of 5-Fluorouracil From Gels In Excised Rat Skin. J Control Release. 1998 Nov 13;55(2-3):297-302.

    合成参考文献


    摘要:Aitken, R. A., Science of Synthesis Knowledge Updates, (2018) 3, 304.
    摘要:Kleoff, M.; Omoregbee, K.; Zimmer, R., Science of Synthesis Knowledge Updates, (2018) 4, 214.
    摘要:Treacy, S. M.; Zhang, X.; Rovis, T., Science of Synthesis, (2021) , 627.
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