专利号:US-5635157-A 优先权日:1992-04-13 标 题 :Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging 发明人:MEASE RONNIE C; KOLSKY KATHRYN L; MAUSNER LEONARD F; SRIVASTAVA SURESH C 摘要:Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.
专利号:US-11111442-B2 优先权日:2018-10-25 标题:Fischer-Tropsch synthesis process comprising a catalyst prepared by addition of an organic compound in gas phase 发明人:GUILLOU FLORENT; CARRETTE P-LOUIS; GUICHARD BERTRAND; DELCROIX DAMIEN 权利人:IFP ENERGIES NOW; TOTAL RES & TECHNOLOGY FELUY 摘要:A Fischer-Tropsch process for synthesizing hydrocarbons, by bringing a catalyst comprising a support and an active phase comprising a Group VIII metal into contact with a feedstock comprising synthesis gas, said catalyst being prepared according to the following steps:n a) a porous support is provided; b) an organic compound containing oxygen and/or nitrogen is added to the porous support; c) a step of bringing said porous support into contact with a solution containing a salt of a precursor of the phase comprising a Group VIII metal is carried out; d) the porous support obtained at the end of step c) is dried;n ncharacterized in that step b) is carried out by bringing together said porous support and said organic compound under conditions of temperature, pressure and duration such that a fraction of said organic compound is transferred in the gaseous state to the porous support.
专利号:US-5639879-A 优先权日:1993-04-02 标题:Macrocyclic polyaminocarboxylates for stable radiometal antibody conjugates for therapy, spect and pet imaging 发明人:MEASE RONNIE C; MAUSNER LEONARD F; SRIVASTAVA SURESH C 权利人:ASS UNIVERSITIES INC 摘要:A simple method for the synthesis of 1,4,7, 10-tetraazacyclododecane N,N'N',N''-tetraacetic acid and 1,4,8,11-tetraazacyclotetradecane N,N',N',N''-tetraacetic acid involves cyanomethylating 1,4,7, 10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane to form a tetranitrile and hydrolyzing the tetranitrile. These macrocyclic compounds are functionalized through one of the carboxylates and then conjugated to various biological molecules including monoclonal antibodies. The resulting conjugated molecules are labeled with radiometals for SPECT and PET imaging and for radiotherapy.
专利号:US-11161099-B2 优先权日:2018-10-25 标题 :Cobalt catalyst comprising a support comprising a mixed oxide phase including cobalt and/or nickel produced from an organic compound from the family of carboyxyanhydrides 发明人:DELCROIX DAMIEN; CORRAL VALERO MANUEL 权利人:IFP ENERGIES NOW 摘要:The present invention relates to a catalyst containing an active cobalt phase, deposited on a support comprising alumina, silica or silica-alumina, said support containing a mixed oxide phase containing cobalt and/or nickel, said catalyst has been prepared by introducing at least one organic compound of the family of carboxyanhydrides. The invention also relates to the process for the preparation thereof, and to the use thereof in the field of Fischer-Tropsch synthesis processes.
专利号:US-5292938-A 优先权日:1992-04-13 标题 :Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
专利号:US-5428156-A 优先权日:1993-04-02 标题:Synthesis of macrocyclic polyaminocarboxylates and their use for preparing stable radiometal antibody immunoconjugates for therapy, spect and pet imaging
参考文献:10.1007/s00425-006-0378-x 摘要:Brouquisse R, Rolin D, Cortès S, Gaudillère M, Evrard A, Roby C. A metabolic study of the regulation of proteolysis by sugars in maize root tips: effects of glycerol and dihydroxyacetone. Planta. 2007 Feb;225(3):693–709. doi: 10.1007/s00425-006-0378-x.