CAS: 1346623-17-3; (2R,3S)-2-(4-(Cyclopentylamino)Phenyl)-1-(2-Fluoro-6-Methylbenzoyl)-N-(4-Methyl-3-(Trifluoromethyl)Phenyl)Piperidine-3-Carboxamide

上下游产品

(2R,3S)-2-(4-(Cyclopentylamino)Phenyl)-1-(2-Fluoro-6-Methylbenzoyl)Piperidine-3-Carboxylic Acid
Ethyl (2R,3S)-2-(4-(Cyclopentylamino)Phenyl)-1-(2-Fluoro-6-Methylbenzoyl)Piperidine-3-Carboxylate

Ethyl (3R,8Ar)-5-(4-Nitrophenyl)-3-Phenyl-3,7,8,8A-Tetrahydro-2H-Oxazolo[3,2-A]Pyridine-6-Carboxylate置于硫酸,Palladium 10% On Activated Carbon,氢气,Potassium Carbonate,溶剂黄146,甲基磺酰氯,N,N-二异丙基乙胺体系中,用 乙醇,二氯甲烷,甲基叔丁基醚,水 用作溶剂,95.0 °C,379.22 Kpa 条件下,反应 115.5H,反应生成(2R,3S)-2-[4-(环戊基氨基)苯基]-1-(2-氟-6-甲基苯甲酰基)-N-[4-甲基3-(三氟甲基)苯基]哌啶-3-甲酰胺
参考文献:Processes And Intermediates In The Preparation Of C5Ar Antagonists
标题:Processes And Intermediates In The Preparation Of C5Ar Antagonists
摘要:提供了中间体和方法,用于制备选择的c5Ar拮抗剂化合物.

专利信息

专利号:US-2025236897-A1
优先权日:2022-02-16
标 题 :Processes for preparation of avacopan and intermediates thereof
发明人：GYUJTO IMRE; PAAL TIHAMER; JUHASZ ZSUZSA POTARINE; ESZENYI DANIEL; ZAHUCZKY GABOR JOZSEF; KONDOR ZOLTAN; RENGASAMY VADIVELAN; PRAJAPATI RAMKARAN; DAUND VAIBHAV SURESH; SAINGER SHACHI; KADU RUSHIKESH; SHARMA VISHAL
权利人:TEVA PHARMACEUTICALS INT GMBH
摘要:The present disclosure encompasses a process for chiral resolution of racemic amines, particularly ethyl 2-(4-((tert-butoxycarbonyl)amino)phenyl)piperidine-3-carboxylate, into its desired isomer, ethyl (2R,3S)-2-(4-((tert-butoxycarbonyl)amino)phenyl)-piperidine-3-carboxylate, which is an intermediate useful in the synthesis of Avacopan.

专利号:US-10316018-B2
优先权日:2015-08-27
标题 :Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators
发明人：LEE KATHERINE LIN; ALLAIS CHRISTOPHE PHILIPPE; DEHNHARDT CHRISTOPH MARTIN; GAVRIN LORI KRIM; HAN SEUNGIL; HEPWORTH DAVID; LEE ARTHUR; LOVERING FRANK ELDRIDGE; MATHIAS JOHN PAUL; OWEN DAFYDD RHYS; PAPAIOANNOU NIKOLAOS; SAIAH EDDINE; STROHBACH JOSEPH WALTER; TRZUPEK JOHN DAVID; WRIGHT STEPHEN WAYNE; ZAPF CHRISTOPH WOLFGANG
权利人:PFIZER
摘要:Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-114262291-B
优先权日:2022-01-04
标 题:Synthesis method of atorvastatin