CAS: 14328-51-9; H-Chg-Oh

相似化合物

191611-20-8 14328-52-0 5664-29-9

上下游产品

CAS号2935-35-5 (|S|)-(+)-α-苯甘氨酸 | CAS号103-01-5 N-苯基甘氨酸 | CAS号40651-95-4 2-amino-2-cyclo... | CAS号107020-80-4 N-乙酰基-DL-环己基甘氨酸 | CAS号2043-61-0 环己烷甲醛 | CAS号87251-26-1 (S)-2-amino-2-(... | CAS号32908-43-3 (-)-(S)-N-(cycl... | CAS号32908-36-4 (R)-cyclohexyl(... | CAS号402958-96-7 (2S)-2-环己基-N-(2... | CAS号69901-75-3 CBZ-L-环己基甘氨酸 | CAS号107202-39-1 N-B°C-L-环己基甘氨醇 | CAS号109183-71-3 B°C-L-环己基甘氨酸

N-苯基甘氨酸置于pto2体系中,用94%的收率获得l-环己基甘氨酸
参考文献:Endothelin Converting Enzyme Inhibitors
标题:Endothelin Converting Enzyme Inhibitors
摘要:抑制内皮素转化酶的化合物已被披露.这些化合物可用于治疗高血压,充血性心力衰竭,心肌梗死,再灌注损伤,冠状动脉狭窄,脑血管痉挛,急性肾衰竭,非甾体抗炎药诱导的胃溃疡,环孢霉素诱导的肾毒性,内毒素诱导的毒性,哮喘和动脉粥样硬化.

专利信息

专利号:US-2023212788-A1
优先权日:2020-03-26
标 题:New method for automated on-demand biomolecular array synthesis
发明人：ZHANG YIXIN; LIN WEILIN
权利人:UNIV DRESDEN TECH
摘要:The invention provides an amphiphilic coating for the direct and rapid synthesis of an array of peptides and small molecular compounds on a planar surface of a solid support, comprising a hydrophilic chemical structure and a lipophilic group, wherein said peptides and small molecular compounds differ from spot to spot from each other in the chemical structure, characterized in that said amphiphilic coating possesses low wettability to polar aprotic solvents used in the array synthesis; said amphiphilic coating possessing low wettability is designed that it can be converted to a coating possessing high wettability by hydrolysis of the lipophilic group; and said amphiphilic coating comprises an amino group for the reaction with an electrophilic reagent. The invention further provides a solid support comprising said amphiphilic coating and a method for method for the direct and rapid synthesis of an array of peptides and small molecular compounds on a planar surface of a solid support, wherein said planar surface of a solid support comprises said amphiphilic coating. Said method includes the enhancing of the wettability of a glass surface to organic solvents to realize automated on-demand biomolecular array synthesis comprising both, peptides and small molecular compounds. The amphiphilic surface can be switched to a hydrophilic surface, resulting in high density arrays suitable for protein- and cell-based screening.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:EP-4424821-A1
优先权日:2023-03-01
标题:Enzymatic synthesis of odilorhabdin and related peptides/proteins comprising non-standard amino acid residues
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to a novel method of preparing a non-standard amino acid or a peptide/protein comprising a non-standard amino acid residue, as appropriate, wherein said amino acid residue is selected from 2,4-diamino-3-hydroxybutyrate, L-5-hydroxylysine, L-3-hydroxyarginine, 2,3-didehydroarginine by using enzymatic transformations. Accordingly, the present invention further relates to a method of preparing a peptide/protein comprising one or more non-standard amino acids selected from 2,4-diamino-3-hydroxybutyrate, L-5-hydroxylysine, L-3-hydroxyarginine and 2,3-didehydroarginine. The methods of the present invention are particularly useful in enzyme-assisted preparation of odilorhabdins and their derivatives. The present invention further relates to a polypeptide having 2,4-diaminobutyrate-3-hydroxylase activity and its use for catalyzing a hydroxylation at position 3 of 2,4-diaminobutyrate, to a polypeptide having having L-arginine 3-hydroxylase activity and its use for catalyzing a hydroxylation at position 5 of L-lysine, to a polypeptide having L-arginine 3-hydroxylase activity and its use for for catalyzing a hydroxylation at position 3 of L-arginine, and to a polypeptide having a deacylase activity, which is preferably capable of removing fatty acyl from the N-terminus of an odilorhabdin, and its use for catalyzing a deacylation, preferably for removing a fatty acyl from the N-terminus of an odilorhabdin.

专利号:WO-2013131978-A1
优先权日:2012-03-07
标 题:Process for the preparation of intermediates useful in the preparation of a viral protease inhibitor
发明人：MANTEGAZZA SIMONE; ATTOLINO EMANUELE; ALLEGRINI PIETRO
权利人:DIPHARMA FRANCIS SRL
摘要:Process for the preparation of intermediates useful in the synthesis of the viral protease inhibitor Telaprevir. The claimed process involves reacting formula (IV) with a formula (III) compound using DMMTM as coupling reagent to get a formula (II) compound.

专利号:US-6552166-B1
优先权日:1999-10-19
标 题:Process for the preparation of conjugates useful in the treatment of prostate cancer
发明人：LYNCH JOSEPH E; ROBBINS MICHAEL A; SHI YAO-JUN; LIEBERMAN DAVID R
权利人:MERCK & CO INC
摘要:The present invention is directed to the improved synthesis of compounds of formula I:which may be useful in the treatment of prostate cancer. Such compounds are synthesized in the presence of a carboxyl activating agent, an additive and a base for the preparation of a PSA conjugate which comprises an anthracycline antibiotic and an oligopeptide.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.