专利号:US-6903227-B2 优先权日:2000-06-02 标题:Synthesis of 2-acyl substituted chromanes and intermediates thereof 发明人:KANTER JAMES; MULLINS JOHN J G; PANDEY ANJALI; SCARBOROUGH ROBERT 权利人:MILLENNIUM PHARM INC 摘要:Novel processes for producing enantiomerically enriched and enantiomerically pure compositions of 2-acyl substituted chromane compounds, and 2-acylchromane compounds that are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors are disclosed. Further disclosed are processes for producing salts such as acid addition salts for such enantiomerically enriched compositions.
专利号:WO-0192250-A2 优先权日:2000-06-02 标 题 :Synthesis of 2-acyl substituted chromanes and intermediates thereof
专利号:WO-2024132278-A1 优先权日:2022-12-20 标题:Synthesis, pharmacology and use of new water-soluble and selective fms-like tyrosine kinase 3 (flt3) inhibitors 发明人:MAHBOOBI SAVOSH; WIRTH LUKAS; PONGARTZ HERWIG; SELLMER ANDREAS 权利人:UNIV REGENSBURG 摘要:The present application relates to compounds of formula (I) for inhibiting FLT3. The present application further relates to a composition, preferably pharmaceutical composition, comprising a compound or a pharmaceutically acceptable salt thereof and comprising a pharmaceutically acceptable excipient and/or carrier. The present application also relates to a compound or composition for use in medicine. The present application also relates to a compound or composition for use in a method of preventing or treating cancer, preferably blood cancer, more preferably leukemia, even more preferably acute myeloid leukemia (AML). Furthermore, the present application relates to a method of preparing a compound.
专利号:US-3984441-A 优先权日:1971-06-21 标 题:Chromonealdehyde compounds and process for the production thereof 发明人:NOHARA AKIRA; UMETANI TOMONOBU; MIYATA YOSHIBUMI; SANNO YASUSHI 权利人:TAKEDA CHEMICAL INDUSTRIES LTD 摘要:There are provided compounds of the general formula ##SPC1## n Wherein R is a hydroxy, alkyl, acyloxy, halogen, nitro, substituted or unsubstituted amino, alkoxy, carboxy or a group derived from a carboxy group and m is 0, 1 or 2 except where m is 2, the two R groups are both hydroxy groups. n The present invention is also concerned with a process for preparing the chromonealdehyde compounds. The chromonealdehyde compounds are characterized by antiallergic properties and are therefore useful as prophylactic and therapeutic agents for allergic asthma, allergic dermatitis and other allergic diseases and also are valuable as intermediates for the synthesis of other pharmaceutical compounds having the chromone nucleus.
专利号:US-2003233002-A1 优先权日:2000-06-02 标 题:Synthesis of 2-Acyl substituted chromanes and intermediates thereof
专利号:CN-103980257-A 优先权日:2014-05-28 标题 :Synthesis of 8-nitro-2-tetrazolyl-4-carbonylbenzopyran
参考标题:Organocatalyzed Kabbe Condensation Reaction For Mild And Expeditious Synthesis Of 2,2‐dialkyl And 2‐spiro‐4‐chromanones 作者:Naval P. Kapuriya,Jasmin J. Bhalodia,Mrunal A. Ambasana,Rashmi B. Patel,Atul H. Bapodra 摘要:An Expeditious Kabbe Condensation Reaction For The Synthesis Of 2,2‐dialkyl And 2‐spiro‐chroman‐4(1H)‐ones Has Been Developed Using Pyrrolidine‐butanoic Acid In Dmso As Bifunctional Organocatalyst. Unlike Existing Methods, This Reaction Proceeds At Room Temperature With High Yields, Rendering It An Attractive Method To Synthesize A Vast Variety Of Privileged 4‐chromones.
合成参考文献
摘要:Aitken, K. M.; Aitken, R. A., Science of Synthesis, (2007) 31, 1215.