CAS: 17231-95-7; 2,3-Dichlorobenzenethiol

上下游产品

CAS号87-61-6 1,2,3-三氯苯 | CAS号608-27-5 2,3-二氯苯胺 | CAS号17733-25-4 1,2-dichloro-3-... | CAS号882257-11-6 P005091 | CAS号79962-31-5 1,2-dichloro-3-... | CAS号6390-19-8 2-(2,3-二氯苯基硫代)乙酸

三氯苯置于sodium Hydrogensulfide,氨,Copper Diacetate体系中,化学反应生成2,3-二氯苯硫酚
参考文献:Takikawa,Kogyo Kagaku Zasshi / Journal Of The Society Of Chemical Industry,1967,Vol. 70,P. 1384,1387
标题:Takikawa,Kogyo Kagaku Zasshi / Journal Of The Society Of Chemical Industry,1967,Vol. 70,P. 1384,1387

专利信息

专利号:US-2023010886-A1
优先权日:2019-09-23
标 题 :Shp2 inhibitors and uses thereof
发明人：XIE YINONG; BABISS LEE E
权利人:SUZHOU PUHE BIOPHARMA CO LTD
摘要:Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.

专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

专利号:US-10561655-B2
优先权日:2018-03-21
标 题 :SHP2 inhibitors and uses thereof
发明人：XIE YINONG; BABISS LEE E
权利人:SYNBLIA THERAPEUTICS INC
摘要:Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.

专利号:US-10988466-B2
优先权日:2017-03-23
标题:Heterocyclic derivatives useful as SHP2 inhibitors
发明人：MA CUNBO; GAO PANLIANG; HU SHAOJING; XU ZILONG; HAN HUIFENG; WU XINPING; KANG DI
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

专利号:CN-106995400-A
优先权日:2017-04-10
标 题:A kind of compound and its salt and synthesis method thereof