CAS: 218600-44-3; (4As,6Ar,6Bs,8Ar,12As,14Ar,14Bs)-11-Cyano-2,2,6A,6B,9,9,12A-Heptamethyl-10,14-Dioxo-1,3,4,5,6,6A,6B,7,8,8A,9,10,12A,14,14A,14B-Hexadecahydropicene-4A(2H)-Carboxylic Acid

相似化合物

229019-44-7 10106-41-9 61919-52-6

上下游产品

CAS号218600-53-4 甲基巴多索隆 | CAS号65023-19-0 Methyl (3α,5ξ,1... | CAS号65023-20-3 (4AS,6AR,6BS,10... | CAS号218600-50-1 3,12-二氧代齐墩果-9(1... | CAS号218600-52-3 (4AS,6AR,6BS,13... | CAS号305818-39-7 Methyl (2E,5ξ,1... | CAS号305818-40-0 Methyl (5ξ,18α)... | CAS号1707-75-1 1,1-二苯基-2-苦味酰肼

Methyl (4As,6Ar,6Bs,8Ar,12As,14Ar,14Bs)-11-Formyl-2,2,6A,6B,9,9,12A-Heptamethyl-10,14-Dioxo-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,14,14A,14B-octadecahydropicene-4A(2H)-Carboxylate置于苯基氯化硒,盐酸羟胺,Sodium Methylate,Lithium Iodide体系中,用 甲醇,乙醚,乙醇,水,乙酸乙酯,N,N-二甲基甲酰胺 用作溶剂,化学反应生成2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸
参考文献:Therapeutic Compounds And Methods Of Use
标题:Therapeutic Compounds And Methods Of Use
摘要:化合物和方法可用于化学预防治疗诸如癌症,阿尔茨海默病,帕金森病,炎症性肠病和多发性硬化等疾病.

专利信息

专利号:WO-2023213264-A1
优先权日:2022-05-05
标 题 :Synthesis of amide compound and use thereof
发明人：WANG ZHAOYIN; ZHANG JIAN; CAO JINRUI
权利人:SHANGHAI INST ORGANIC CHEMISTRY CAS
摘要:The present invention relates to a novel oleanamide derivative for activating a KEAP/NRF2/ARE signaling pathway. The compound of the present invention is represented by general formula (I), wherein L, R 3 , R 4 , Z, and n are set forth in the description specification and the claims. Also disclosed are a method for preparing the compound represented by general formula I and an activity test result thereof for activating the KEAP/NRF2/ARE signaling pathway. The compound represented by general formula (I) of the present invention can be used for treating and preventing multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Friedreich's ataxia (FRDA), spinal muscular atrophy (SMA), neuromyelitis optica (NMO), spinocerebellar ataxia (SCA), and other neurodegenerative diseases, and can also be used for treating cerebral apoplexy, autoimmune diseases, diabetes, kidney diseases, and other chronic diseases.

专利号:US-9750749-B2
优先权日:2010-05-03
标题 :Methods of treating thyroid eye disease
发明人：PHIPPS RICHARD P; GUO NAXIN; FELDON STEVEN
权利人:PHIPPS RICHARD P; GUO NAXIN; FELDON STEVEN; UNIV ROCHESTER
摘要:The present invention relates to a methods and compositions for the treatment of and management of symptoms for thyroid eye disease. The methods include administering to a patient having thyroid eye disease an agent that interferes with hyaluronan synthesis in an amount that is effective to inhibit hyaluronan synthesis in a retro-ocular space. The pharmaceutical compositions that includes a carrier suitable for ophthalmic delivery and an agent that interferes with hyaluronan synthesis. Combination therapies are also disclosed.

专利号:US-8067394-B2
优先权日:2006-11-17
标 题:Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
发明人：HONDA TADASHI; SUNDARARAJAN CHITRA; GRIBBLE GORDON W; SPORN MICHAEL B; LIBY KAREN T
权利人:HONDA TADASHI; SUNDARARAJAN CHITRA; GRIBBLE GORDON W; SPORN MICHAEL B; LIBY KAREN T; DARTMOUTH COLLEGE
摘要:This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these compounds are also disclosed. The inventors demonstrate the ability of these new TBEs to inhibit proliferation of human myeloma cells, inhibit the induction of iNOS in cells stimulated with interferon-γ, induce heme oxygenase-1 (HO-1), induce CD11b expression—a leukemia differentiation marker, inhibit proliferation of leukemia cells, induce apoptosis in human lung cancer, and induce apoptosis in other cancerous cells. The TBEs of this invention are expected to be useful agents for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.

专利号:CN-117050134-A
优先权日:2022-05-05
标 题 :Synthesis of amide compounds and their uses

专利号:CN-108434151-A
优先权日:2008-01-11
标题 :Synthesis of triterpenoids and method for treating diseases

专利号:CN-104739841-B
优先权日:2008-01-11
标题:Synthesis of triterpenoids and method for treating diseases