4,5,6-三氯嘧啶置于氨体系中,用55%的收率获得产物4-氨基-5,6-二氯嘧啶 参考文献:Makosza; Ostrowski,Polish Journal Of Chemistry,2000,Vol. 74,# 10,P. 1355-1361 标题:Makosza; Ostrowski,Polish Journal Of Chemistry,2000,Vol. 74,# 10,P. 1355-1361
专利信息
专利号:WO-2025101716-A1 优先权日:2023-11-07 标题:Processes for synthesis of trifunctionalized sulfur(vi) compounds 发明人:LOPCHUK JUSTIN; SHULTZ ZACHARY; ATHAWALE PARESH 权利人:H LEE MOFFITT CANCER CT & RES 摘要:This disclosure describes processes for the asymmetric synthesis of trifunctionalized sulfur(VI) containing organic compounds of Formula I and Formula VI, as well as compounds of Formula I and Formula VI prepared by the processes described.
专利号:US-10793551-B2 优先权日:2017-10-19 标 题:Benzimidazole-indole inhibitors of Mnk1 and Mnk2 发明人:ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; XIANG ALAN X 权利人:EFFECTOR THERAPEUTICS INC 摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I or Formula II, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , Y 1 , Y 2 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 and R 13 are as defined in the specification. The inventive Formula I and Formula II compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.