CAS: 34584-69-5; 3,6-Dichloro-4,5-Dimethylpyridazine

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CAS号5754-17-6 4,5-二甲基哒嗪-3,6-二酮 | CAS号766-39-2 二甲基马来酸酐 | CAS号63751-07-5 1-amino-3,4-dim... | CAS号76593-36-7 3 -氨基- 6 -氯-4,5二甲基哒嗪 | CAS号1204978-02-8 3-benzyl-6-chlo...

2,3-二甲基马来酸酐置于一水合肼,三氯氧磷体系中,用 水 用作溶剂,化学反应 19.0H,反应生成3,6-二氯-4,5-二甲基哒嗪
参考文献:哒嗪氮氧化物作为活性氧的光活化替代物
标题:哒嗪氮氧化物作为活性氧的光活化替代物
摘要:开发了一种从哒嗪n-氧化物光诱导析出原子氧的方法.这种尚未开发的氧同素异形体介导复杂的多功能分子内的芳烃 C-H 氧化.还开发了一种水溶性哒嗪n-氧化物,并显示其可促进水溶液中的光诱导 Dna 裂解.总而言之,这些研究强调了哒嗪n-氧化物作为可光活化的 O( 3 P) 前体在有机合成和化学生物学中的应用.
Doi:10.1021/acs.Orglett.2C00227

专利信息

专利号:US-12275752-B2
优先权日:2019-06-13
标 题 :Class of phosphine nitrogen ligand with multiple chiral centers and its synthesis method and application
发明人：MA SHENGMING; LIU QI; XU HAIBO
权利人:SHANGHAI INST ORGANIC CHEMISTRY CAS
摘要:The present invention discloses a phosphine nitrogen ligand with multiple chiral centers and its synthesis method and application. The ligand has the axial chirality of a biaryl skeleton and the central chirality of a chiral amine. The chiral ligand is synthesized from commercially available raw materials through a simple five-step reaction, and the resulting diastereomer can be separated by simple column chromatography or recrystallization. The chiral phosphine nitrogen ligand synthesized by the present invention can catalyze the asymmetric three-component coupling reaction of terminal alkynes, aldehydes and amines, and realize the efficient preparation of chiral propargyl amines with high optical activity.

专利号:CN-112079865-A
优先权日:2019-06-13
标题 :A class of phosphine nitrogen ligands with multiple chiral centers and their synthesis methods and applications

专利号:US-2022332739-A1
优先权日:2019-06-13
标题 :A class of phosphine nitrogen ligand with multiple chiral centers and its synthesis method and application

专利号:CN-112079865-B
优先权日:2019-06-13
标题:A class of phosphine nitrogen ligands with multiple chiral centers and their synthesis methods and applications