CAS: 37777-76-7; 2-Chloro-6-Fluorophenylacetic Acid

二氧化碳,2-氯-6-氟氯苄置于四甲基乙二胺,4Dpaipn,Lithium Tert-Butoxide体系中,用 N,N-二甲基甲酰胺 用作溶剂,20.0 °C,101.33 Kpa 条件下,反应 8.0H,以73%的收率获得2-氯-6-氟苯乙酸
参考文献:可见光光氧化还原催化氯化苄与 Co2 的羧化反应:温和且不含过渡金属
标题:可见光光氧化还原催化氯化苄与 Co2 的羧化反应:温和且不含过渡金属
摘要:已经报道了用co 2对苄基氯和溴进行可见光光氧化还原催化羧化.使用廉价的有机染料作为光催化剂和胺作为电子供体,这种羧化在没有敏感的有机金属试剂,过渡金属催化剂或金属还原剂的情况下进行得很好.范围广泛的可商购且廉价的苄基卤化物经过这种羧化作用以中等至高产率产生有价值的芳基乙酸,包括几种药物分子和药物前体.此外,该反应具有温和的反应条件(1 个大气压的 Co 2和室温),广泛的底物范围,非常好的官能团耐受性,易于扩展和低催化剂负载,从而为芳基乙酸的组装提供了一种有效的方法.
Doi:10.1016/s1872-2067(21)63859-7

专利信息

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:US-11897857-B2
优先权日:2019-02-15
标 题 :Isotopically-stabilized tetronimide compounds
发明人：OLSEN MARK JON; SEERDEN JEAN PAUL
权利人:UNIV MIDWESTERN
摘要:Isotopically-stabilized tetronimide compounds comprising one or more deuterium atoms, derivatives, and intermediates, thereof, including methods for their synthesis, pharmaceutical compositions thereof, and methods of using these compounds to interact with target molecules in cell-free samples, cell- and tissue-based assays, animal models, and in a subject are disclosed. One aspect relates to molecules that modulate the expression or catalytic activity of aspartyl (asparaginyl) β-hydroxylase (ASPH) within or on the surface of a cell. Other aspects of the invention relate to use of the molecules disclosed herein to diagnose, ameliorate, or treat cell proliferation disorders and related diseases. Related aspects include uses of the compounds to modulate the activity of viruses, as anti-hyperlipidemia agents, and as agents to ameliorate or treat thrombosis and related cardiovascular and metabolic disorders.

专利号:US-5734067-A
优先权日:1994-09-28
标题 :Anti-oxidative tricyclic, condensed heterocyclic compound
发明人：JINNO SHUJI; KOGURE YASUYO; ONUKI HIROYUKI; OKITA TAKAAKI
权利人:NIPPON SUISAN KAISHA LTD
摘要:Providing a novel tricyclic, condensed heterocyclic compound having an anti-oxidative action and being promising for use in pharmaceutical agents, cosmetics, chemical products and the like. By chemical synthesis, a novel anti-oxidative, tricyclic, condensed heterocyclic compound represented by the following formula: ##STR1## (wherein X--Y represents CH 2 --Câ•?O, CH 2 --CH 2 or CHâ•?CH; Z represents O, S, or Sâ•?O; R 1 to R 8 represent independently those selected from the group consisting of hydrogen atom, a hydroxyl group, a halogen group, a lower alkyl group, a lower alkoxyl group, a lower alkyl ketone group and CF 3 ; and at least two of R 1 to R 4 are hydroxyl groups); and the salts thereof are provided. The compound has an anti-oxidative activity at the same degree as or higher than the activity of α-tocopherol, so the compound is promising as a therapeutic drug for a variety of diseases, such as cancer, arteriosclerosis, or liver diseases, in which it is believed that biological lipid peroxides may b involved.

专利号:CN-1242007-A
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising such compounds, and methods of inhibiting beta amyloid peptide release and/or its synthesis using such compounds