CAS: 39903-01-0; 2-Amino-5-Bromo-3-Pyridinol

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N-(3-羟基吡啶-2-基)氨基甲酸乙酯置于n-溴代丁二酰亚胺(Nbs),水,Sodium Hydroxide体系中,用 二苯醚,乙腈 用作溶剂,化学反应 9.0H,反应生成2-氨基-5-溴-3-羟基吡啶
参考文献: Pyrimidine And Triazine Derivatives And Their Use As Axl Inhibitors[fr] Dérivés De Pyrimidine Et De Triazine,Et Leur Utilisation Comme Inhibiteurs D'Axl
标题: Pyrimidine And Triazine Derivatives And Their Use As Axl Inhibitors[fr] Dérivés De Pyrimidine Et De Triazine,Et Leur Utilisation Comme Inhibiteurs D'Axl
摘要:公式(I)的化合物: (I) 这些化合物的制备方法,包含这些化合物的组合物,以及这些化合物的用途.

专利信息

专利号:WO-2023098592-A1
优先权日:2021-11-30
标题:Preparation method for carbon-loaded iron-based catalyst and use thereof in synthesis of intermediates of anti-cancer inhibitors

专利号:CN-114315595-B
优先权日:2021-11-30
标题 :Preparation method of a carbon-supported iron-based catalyst and its application in the synthesis of anti-cancer inhibitor intermediates

专利号:US-8785632-B2
优先权日:2004-08-26
标 题:Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
发明人：CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE
权利人:CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE; AGOURON PHARMA; PFIZER
摘要:Enantiomerically pure compound of formula 1 n nare provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

专利号:US-2006178374-A1
优先权日:2004-08-26
标 题 :Aminoheteroaryl compounds as protein kinase inhibitors
发明人：CUI JINGRONG J; FUNK LEE A; JIA LEI; KUNG PEI-PEI; MENG JERRY J; NAMBU MITCHELL D; PAIRISH MASON A; SHEN HONG; TRAN-DUBE MICHELLE
权利人:AGOURON PHARMA
摘要:Aminoheteroaryl compounds are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

专利号:EP-1784396-B8
优先权日:2004-08-26
标 题 :Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors
发明人：CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE BICH
权利人:PFIZER
摘要:Compounds of formula (1) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

专利号:US-9604966-B2
优先权日:2013-02-16
标 题 :Crizotinib preparation method
发明人：LI YUANQIANG; QIAN JIANQIANG; CHE DAQING
权利人:ZHEJIANG JIUZHOU PHARM CO LTD; ZHEJIANG JIUZHOU PHARM CO LTD
摘要:The present invention relates to the technical field of medicine and organic synthesis, particularly to a method for preparing crizotinib. The method comprises the compound of formula b and the compound of formula e undergoing Suzuki coupling reaction to produce the compound of formula a which then was subjected to deprotection to afford (±) crizotinib.