CAS: 41716-18-1; 1-Methyl-1H-Imidazole-4-Carboxylic Acid

上下游产品

1-甲基-1H-咪唑-4,5-二羧酸 1-Methyl-4,5-Imidazoledicarboxylic Acid 19485-38-2

1-甲基-1H-咪唑-4,5-二羧酸置于n,N-二甲基乙酰胺体系中,化学反应 3.0H,以75%的收率获得产物1-甲基-4-咪唑甲酸
参考文献:Convenient Synthesis Of Methyl 1-Methyl-2,4-Dibromo-5-Imidazolecarboxylate
标题:Convenient Synthesis Of Methyl 1-Methyl-2,4-Dibromo-5-Imidazolecarboxylate
摘要:介绍了三种合成甲基1-甲基-2,4-二溴-5-咪唑甲酸酯(8)的方法.第一种方法是通过肌氨酸的环化,溴化和脱硫步骤进行.第二种方法使用n-甲基咪唑,多溴化和选择性卤素-金属互换.第三种方法最为高效且实用,始于二氨基富马腈(13).通过三乙基原甲酸酯进行环化,随后甲基化和水解得到1-甲基-4,5-咪唑二羧酸(16).区域选择性脱羧后再酯化得到甲基1-甲基-5-咪唑甲酸酯(18).后续的双溴化得到完全取代的咪唑8.在此序列中主要的纯化步骤是酯化步骤后的分馏升华.从二氨基富马腈(13)到甲基1-甲基-2,4-二溴-5-咪唑甲酸酯(8)的总收率为26%,后者是合成三环咪唑熟食诱变剂的关键中间体.
DOI:10.1055/s-1988-27702

专利信息

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2020216836-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:EP-1957644-B1
优先权日:2005-12-01
标 题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2019330618-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries