CAS: 61500-87-6; Methyl 2-Amino-4-(Trifluoromethyl)Benzoate

上下游产品

2-氨基-4-三氟甲基苯甲酸 2-Amino-4-Trifluoromethylbenzoic Acid 402-13-1
2-氨基-5-碘-4-(三氟甲基)苯甲酸甲酯 Methyl 2-Amino-5-Iodo-4-(Trifluoromethyl)Benzoate 872624-52-7
2-硝基-4-(三氟甲基)苯甲酸甲酯 Methyl 2-Nitro-4-Trifluoromethylbenzoate 228418-45-9
2-硝基-4-三氟甲基苯甲酸 2-Nitro-4-Trifluoromethylbenzoic Acid 320-94-5

2-硝基-4-(三氟甲基)苯甲酸甲酯置于钯 氢气,乙酸乙酯,Silica Gel,Isohexane Ethyl Acetate体系中,用 乙酸乙酯 作为反应溶剂,化学反应 3.0H,以to Provide The Title Compound As A White Crystalline Solid (84 G,95%)的收率获得产物2-氨基-4-三氟甲基苯甲酸甲酯
参考文献:Compounds And Method For Treating Dyslipidemia
标题:Compounds And Method For Treating Dyslipidemia
摘要:公式i的化合物,其中n,M,P,Q,Y,R1R2,R3A,R3B,R4,R5和r6的定义如本文所述,并公开了它们的药物组合物和使用方法.

专利信息

专利号:US-9328138-B2
优先权日:2011-11-15
标题:HCV NS3 protease inhibitors
发明人：RUDD MICHAEL T; MCCAULEY JOHN; LIVERTON NIGEL; GRISÉ-BARD CHRISTIANE; BROCHU MARIE-CHRISTINE; CHARRON SYLVIE; AULAKH VIRENDER; BACHAND BENOIT; BEAULIEU PATRICK; ZAGHDANE HELMI; HAN YONGXIN; FERRARA MARCO; HARPER STEVEN; SUMMA VINCENZO; CHACKALAMANNIL SAMUEL; VENKATRAMAN SRIKANTH; SHAH UNMESH; VELAZQUEZ FRANCISCO
权利人:MERCK SHARP & DOHME; MSD ITALIA SRL; MERCK CANADA INC
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.