CAS: 98-96-4; Pyrazine-2-Carboxamide

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19847-12-2 20010-99-5 39204-49-4

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2-胺甲基吡嗪置于c31H29Br2N3Ru,Potassium Tert-Butylate体系中,用 叔丁醇 作为反应溶剂,化学反应 24.0H,以94%的收率获得产物吡嗪酰胺
参考文献:由环状介离子卡宾 (Mic) 稳定的 Ru 配合物催化伯胺有氧氧化为酰胺
标题:由环状介离子卡宾 (Mic) 稳定的 Ru 配合物催化伯胺有氧氧化为酰胺
摘要:伯胺催化有氧氧化为酰胺,使用预催化剂 [ru(Cod)(L 1)Br 2] (1) 带有环状 π 共轭咪唑 [1,2-A][1,8] 萘啶基公开了介离子卡宾配体l 1.该催化方案以其高活性和选择性,广泛的底物范围和适中的反应条件而著称.多种伯胺,Rch 2 Nh 2(r =脂族,芳族和杂芳族),被转换为使用环境空气作为在ko的亚化学计量的量的存在下用氧化剂相应的酰胺吨卜在吨丁醇.进行了一组控制实验,哈米特关系,动力学研究和 Dft 计算,以揭示使用1的胺氧化的机械细节.催化反应涉及分别通过氧代和羟基配体提取金属键合伯胺的两个胺质子和两个苄基氢原子.hammett 研究不支持用于苄基 C-H 键裂解的 β-氢化物转移步骤.催化氧化产生的腈经过水合得到酰胺作为最终产物.
DOI:10.1039/d1Cy01541A

专利信息

专利号:US-6566292-B2
优先权日:2001-03-27
标 题 :Process for the enhancement of the cycle life of a zinc-chromium based catalyst in the synthesis of 2-methylpyrazine
发明人：POTHARAJU SEETHARAMANJANEYA SA; RAGHAVAN KONDAPURAM VIJAYA; RAO PANJA KANTA; KULKARNI SHIVANAND JANARDAN; RAO KATABATHINI NARASIMHA; GOPINATH RAJESH; FARSINAVIS SURESH; MESHRAM HARSHADAS MITARAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to enhancement of the cycle life of a zinc chromium based catalyst used in the synthesis of 2-methylpyrazine by increasing the reaction temperature step-wise, starting from a low temperature, while monitoring the levels of total conversion and selectivity towards pyrazine. The catalyst can be regenerated after each cycle of use without substantial loss of activity.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2024197774-A1
优先权日:2021-04-16
标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
发明人：LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
权利人:UNIV TEXAS
摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

专利号:EP-1373226-B1
优先权日:2001-03-30
标题 :Process for the enhancement of cycle life of a zinc-chromium based catalyst in the synthesis of 2-methylpyrazine
发明人：POTHARAJU SEETHARAMANJANEYA SA; RAGHAVAN KONDAPURAM VIJAYA; RAO PANJA KANTA; KULKARNI SHIVANAND JANARDAN; RAO KATABATHINI NARASIMHA; GAPINATH RAJESH; FARSINAVIS SURESH; MESHRAM HARSHADAS MITARAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to enhancement of the cycle life of a zinc chromium based catalyst used in the synthesis of 2-methylpyrazine by increasing the reaction temperature step-wise, starting from a low temperature, while monitoring the levels of total conversion and selectivity towards pyrazine. The catalyst can be regenrated after each cycle of use without substantial loss of activity.

专利号:US-2017268027-A1
优先权日:2014-12-22
标题:Method for synthesis of fatty acids
发明人：CESCUT JULIEN; URIBELARREA JEAN-LOUIS; GUILLOUET STEPHANE; MOLINA-JOUVE CAROLE; SAGNAK RANA
权利人:INST NAT DES SCIENCES APPLIQUEES DE TOULOUSE; CENTRE NAT RECH SCIENT; AGRONOMIQUE INST NAT RECH; FIDOP (FONDS DE DEV DES FILIERES DES OLEAGINEUX ET DES PROTEAGINEUX)
摘要:Disclosed is a method for synthesis of fatty acids by culturing a eukaryotic microorganism from the fungi kingdom, that is naturally oleaginous or rendered oleaginous. The culture is performed in the presence a fatty acid synthase inhibitor in the culture medium.

专利号:US-2011087037-A1
优先权日:2007-10-31
标题:Synthesis of ring b abeo-sterols as novel inhibitors of mycobacterium tuberculosis
发明人：RODRIGUEZ-PIERLUISSI ABIMAEL D; WEI XIAOMEI
权利人:INTELLECTUAL PROPERTY AND TECHNOLOGY VIC OFF OF
摘要:Novel 3β-hydroxy-Δ 5 -steroid analogs possessing a contracted cyclopentane B-ring provide good inhibitory activity against Mycobacterium tuberculosis . The 5(6→7)abeo-sterol nucleus present in compounds of the invention represents a novel scaffold for the development of new antitubercular agents.