2-吡啶甲酸乙酯置于乙酸乙酯体系中,化学反应生成2-乙酰基吡啶 参考文献:Gilman Et Al.,Journal Of The American Chemical Society,1946,Vol. 68,P. 2399 标题:Gilman Et Al.,Journal Of The American Chemical Society,1946,Vol. 68,P. 2399
专利号:US-11078465-B2 优先权日:2018-02-12 标题:Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols 发明人:NI YE; WANG YUE; DAI WEI; XU GUOCHAO; ZHOU JIEYU 权利人:UNIV JIANGNAN 摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.
专利号:US-10487099-B2 优先权日:2017-06-30 标 题:Synthesis of hypervalent iodine reagents with dioxygen 发明人:POWERS DAVID CHARLES; MAITY ASIM; HYUN SUNG-MIN 权利人:TEXAS A & M UNIV SYS 摘要:Methods of synthesis of hypervalent iodine reagents and methods for oxidation of organic compounds are disclosed.
专利号:US-5539117-A 优先权日:1993-04-13 标题:2-acetyl-6-cyanopyridines and their use as intermediates in the synthesis of oligo-2,6-pyridines 发明人:SNOW ROBERT A; DELECKI DANIEL J; SHAH CHANDRA R; HOLLISTER K ROBERT 摘要:The present invention is directed to 2-acetyl-6-cyanopyridine compounds that are useful as intermediates in the synthesis of oligo-2,6-pyridines. The present invention is also directed to new, simpler, less expensive methods for synthesizing such oligopyridines using the novel 2-acetyl-6-cyanopyridine compounds as intermediates.
专利号:US-8709129-B2 优先权日:2009-07-21 标题 :Compounds useful as ligands of actinides, their synthesis and their uses 发明人:MARIE CÉCILE; MIGUIRDITCHIAN MANUEL; BISSON JULIA; GUILLANEUX DENIS; DUBREUIL DIDIER 权利人:MARIE CÉCILE; MIGUIRDITCHIAN MANUEL; BISSON JULIA; GUILLANEUX DENIS; DUBREUIL DIDIER; COMMISSARIAT ENERGIE ATOMIQUE 摘要:The invention relates to novel compounds which are useful as ligands of actinides, to the synthesis of these compounds and to their uses. n These compounds fit the general formula (I) hereafter: n nwherein R 1 and R 2 , either identical or different, represent H, a linear or branched, saturated or unsaturated C 1 -C 12 hydrocarbon group, a phenyl, benzyl, diphenyl or tolyl group; R 3 represents H, a linear or branched, saturated or unsaturated C 1 -C 12 hydrocarbon group, a phenyl, tolyl or linear or branched C 1 -C 12 alkoxy group; while R 4 represents H, a linear or branched, saturated or unsaturated C 1 -C 12 hydrocarbon group, a phenyl or tolyl group.n n Field of applications: the processing of used nuclear fuels via a hydrometallurgical route.
专利号:US-10435425-B1 优先权日:2018-07-14 标 题:Alpha-selective sialyl donor and its uses for preparation of sialosides 发明人:TSAI YOW-FU; WU YU-FA 权利人:UNIV CHUNG YUAN CHRISTIAN 摘要:Disclosed herein a sialyl donor and its use for the synthesis of gangliosides. The sialyl donor has the structure of, n nwherein, R 1 and R 2 are independently benzoyl, toluenesulfonyl, pivaloyl or acetyl optionally substituted with a halogen; and R 3 is acetyl or —(O)CCH 2 OH. In one preferred embodiment, in the sialyl donor of formula (I), R is acetyl. Also disclosed herein is a method of synthesizing a sialoside. The method comprises steps of: coupling the sialyl donor of formula (I) with a glycosyl acceptor having a primary hydroxyl group in the presence of N-iodosuccinimide (NIS) and trifluoromethanesulfonic acid (TfOH) under suitable conditions; and isolating the sialoside, which has an α-glycosidic linkage. According to preferred embodiments, the coupling is conducted in a solvent selected from the group consisting of, CH 3 CN, CH 3 Cl, and CH 2 Cl 2 at a temperature between −20° C. to −60° C. Additionally or optionally, the coupling is conducted in CH 2 Cl 2 with the presence of a powdered molecular sieve at −40° C.
专利号:US-5663350-A 优先权日:1992-04-01 标题 :Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists 发明人:DURANT GRAHAM J; KHAN AMIN M 权利人:UNIV TOLEDO 摘要:The present invention relates to a novel process for the preparation of highly potent histamine receptor antagonists, in particular histamine H 3 -receptor antagonists. Also disclosed is a novel process for the preparation of intermediates useful in the preparation of histamine receptor antagonists, in particular H 3 -receptor antagonists.
1: Oliveira APA, Ferreira IP, Despaigne AAR, Silva JGD, Vieira ACS, Santos MS, Alexandre-Moreira MS, Diniz R, Beraldo H. Structural studies and antileishmanial activity of 2-acetylpyridine and 2-benzoylpyridine nitroimidazole-derived hydrazones. Acta Crystallogr C Struct Chem. 2019 Mar 1;75(Pt 3):320-328. doi: 10.1107/S2053229619001529. Epub 2019 Feb 15. 2022:4101095. doi: 10.1155/2022/4101095. 3: Pal S, Pal S. trans-(2-Acetylpyridine-kappa2N,O)dichlorobis(dimethyl sulfoxide-kappaS)ruthenium(II). Acta Crystallogr C. 2002 May;58(Pt 5):m273-4. doi: 10.1107/s0108270102003797. Epub 2002 Apr 11. 46(3):918-932. doi: 10.1039/c6dt03657k. 45(3):1063-77. doi: 10.1039/c5dt03912f.
合成参考文献
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