CAS: 1207459-15-1; 5-Acetoxy-2-(((4-Chlorobenzoyl)Oxy)Methyl)Tetrahydrofuran-3-Yl 4-Chlorobenzoate

英文名称5-Acetoxy-2-(((4-Chlorobenzoyl)Oxy)Methyl)Tetrahydrofuran-3-Yl 4-Chlorobenzoate
中文名称5-乙酰氧基-2-(((4-氯苯甲酰基)甲基)四氢呋喃-3-基4-氯苯甲酸酯
IUPAC名称(2R,3S)-5-acetoxy-2-(((4-chlorobenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-chlorobenzoate
其它别名1-O-乙酰基-3,5-二-(4-对氯苯甲酰基)-2-脱氧-D-核糖; 1-O-Acetyl-3,5-Bis(4-Chlorobenzoyl)-2-Deoxy-D-Ribose
CAS编号1207459-15-1
MFCD编号:MFCD20487850
FDA UNII编号:VKX2Q75S7F
分子式:C21H18Cl2O7
分子量:453.27
产品CID: 277748
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: XHRJNOXRTTZFEQ-PAMZHZACSA-N
InChI=1S/C21H18Cl2O7/c1-12(24)28-19-10-17(30-21(26)14-4-8-16(23)9-5-14)18(29-19)11-27-20(25)13-2-6-15(22)7-3-13/h2-9,17-19H,10-11H2,1H3/t17-…
计算化学: 氢键受体数7.0氢键供体数0可旋转键数6

相似化合物

2935933-79-0 1019659-88-1 99886-53-0

物理性质

熔点>89 °C
沸点545.4±50.0 °C at 760 mmHg
密度1.42±0.1 g/cm3(预测)
PSA:88.13
LogP:4.0539
溶解性DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
外观形态白色至类白色固体
储存条件冰箱, 置于惰性气氛下

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H315-H319-H335
防范说明P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

上下游产品

CAS号2353-33-5 地西他滨

合成工艺路线路线简述

海关参考信息

2903919090-氯苯
2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8586729-B2
优先权日:2008-10-03
标题:Synthesis of decitabine
发明人：HENSCHKE JULIAN PAUL; ZHANG XIAOHENG; YU JIANBO; HU KUN; MEI LIJUN
权利人:HENSCHKE JULIAN PAUL; ZHANG XIAOHENG; YU JIANBO; HU KUN; MEI LIJUN; SCINOPHARM TAIWAN LTD
摘要:A method for producing a Î²-enriched protected decitabine comprising:n a) coupling a protected 2-deoxy-ribofuranose with a protected 5-azacytosine in the presence of a catalyst to form a reaction mixture comprising the protected decitabine of formula I; and b) quenching the reaction mixture of step a) with a base. The Î²-enriched protected decitabine so made may be deprotected to produce a decitabine product in a high yield and purity.

专利号:EP-2341772-B1
优先权日:2008-10-03
标题 :Synthesis of decitabine
发明人：HENSCHKE JULIAN PAUL; ZHANG XIAOHENG; YU JIANBO; HU KUN; MEI LIJUN
权利人:SCINOPHARM TAIWAN LTD

专利号:US-2010087637-A1
优先权日:2008-10-03
标题 :Synthesis of Decitabine