CAS: 14464-29-0; 2,5-Dioxopyrrolidin-1-Yl Acetate

该化合物是一种化学化合物,在各种生化应用中,特别是在生物合成领域,作为一种反应中间体,在各种生物化学应用中,特别是在生物合成领域,是一种化学化合物,其特点是能够与主要胺胺类形成稳定的粘合物结合,使其对蛋白,peptides和其他生物分子具有标签作用;复合物具有苏格尼米酸环的特点,它增强了其对核糖分泌的再活动,并且增加了酸性酸性,有助于其在极溶剂中的溶性. NHS-eetate通常用于NHS酯的合成中,因为其温和反应条件和在不产生重大副反应的情况下有选择地修改生物分子的能力得到增强.该化合物一般在干燥条件下保持稳定,但在水分中可以进行水解,导致乙酸和相应的NHS.其应用范围扩大到药物的开发,诊断,以及用于治疗目的的生物合成的准备.

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CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号64-19-7 冰醋酸 | CAS号108-24-7 乙酸酐 | CAS号75-36-5 乙酰氯 | CAS号2524-64-3 氯磷酸二苯酯 | CAS号4743-99-1 4-(羟基氨基)-4-氧代丁酸 | CAS号67007-51-6 N-hydroxysuccin... | CAS号830-03-5 4-硝基苯基乙酸酯 | CAS号79-21-0 过氧乙酸 | CAS号108320-87-2 尿苷 5′-二磷酸-N-乙酰半... | CAS号114117-42-9 B°C-4-(乙酰氨基)-L-苯丙氨酸 | CAS号4743-99-1 4-(羟基氨基)-4-氧代丁酸

合成工艺路线路线简述

    4-(羟基氨基)-4-氧代丁酸置于氨体系中,化学反应生成乙酸-N-琥珀酰亚胺酯
    参考文献:Hantzsch; Urbahn,Chemische Berichte,1895,Vol. 28,P. 760
    标题:Hantzsch; Urbahn,Chemische Berichte,1895,Vol. 28,P. 760

    海关参考信息

    专利信息


    专利号:US-4148788-A
    优先权日:1978-01-23
    标 题:Synthesis of thymosin α1
    发明人:WANG SU-SUN
    权利人:HOFFMANN LA ROCHE
    摘要:Thymosin α 1 , was chemically synthesized by the fragment condensation of the protected amino terminal tetradecapeptide with the protected carboxyl terminal tetradecapeptide and by solid phase peptide synthesis. Thymosin α 1 is active as an agent which affects regulation, differentiation and function of thymus dependent lymphocytes (T cells).

    专利号:US-8877171-B2
    优先权日:2010-02-03
    标 题 :Polyanionic multivalent macromolecules for intracellular targeting of proliferation and protein synthesis
    发明人:LICHA KAI; SCHIRNER MICHAEL; WELKER PIA; HAAG RAINER; WEINHART MARIE; PAULUS FLORIAN
    权利人:LICHA KAI; SCHIRNER MICHAEL; WELKER PIA; HAAG RAINER; WEINHART MARIE; PAULUS FLORIAN; MIVENION GMBH
    摘要:The present invention relates generally to methods and compositions for targeting of intracellular molecules involved in proliferation and protein synthesis of activated cells using polyanionic multivalent macromolecules. In particular aspect, multiple sulfate groups linked to polyol are specifically targeted to the cytoplasm and nucleus of proliferating and activated cells. The invention further comprises novel polyanionic macromolecular compounds and formulations.

    专利号:US-2009162290-A1
    优先权日:2005-09-09
    标 题 :Method for the synthesis of penta-pendant enantiomer-pure chelators and process for therapeutically active bioconjugates preparation by a covalent binding thereof
    发明人:BENES IVAN; CIHELNIK SIMON; DROZ LADISLAV; SRAMEK MARTIN
    权利人:THERAPHARM GMBH
    摘要:The present invention provides a method for synthesis and binding methods of pentapendant enantiomer-pure chelators of formula (VII) wherein R 1 , R 2 , R 3 , R 4 are groups forming an adequate enantiomer of the chelator; and X 1 -X 5 , Y 1 -Y 5 , Z 1 -Z 5 each individually forming pendant chelating groups.

    专利号:US-8598089-B2
    优先权日:2003-12-17
    标题 :Methods for synthesis of encoded libraries
    发明人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
    权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
    摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

    专利号:US-2004030209-A1
    优先权日:2000-11-30
    标 题:Method for the production of alkyl aryl sulphonates
    发明人:NARBESHUBER THOMAS; STEINBRENNER ULRICH; KRACK GERHARD
    摘要:The preparation of alkylaryl compounds takes place by n 1) preparation of a mixture of, on statistical average, predominantly monobranched C 10-14 -olefins by n a) reaction of a C 4 -olefin mixture over a metathesis catalyst for the preparation of an olefin mixture comprising 2-pentene and/or 3-hexene, and optional removal of 2-pentene and/or 3-hexene, followed by dimerization of the resulting 2-pentene and/or 3-hexene over a dimerization catalyst to give a mixture comprising C 10-12 -olefins, and optionally removal of the C 10-12 -olefins, or n b) extraction of predominantly monobranched paraffins from kerosene cuts and subsequent dehydrogenation, or n c) Fischer-Tropsch synthesis of olefins or paraffins, where the paraffins are dehydrogenated, or n d) dimerization of shorter-chain internal olefins, or n e) isomerization of linear olefins or paraffins, where the isomerized paraffins are dehydrogenated, n 2) reaction of the olefin mixture obtained in stage 1) with an aromatic hydrocarbon in the presence of an alkylation catalyst which contains zeolites of the faujasite type.

    专利号:US-8410028-B2
    优先权日:2003-12-17
    标 题:Methods for synthesis of encoded libraries
    发明人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
    权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
    摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
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    合成参考文献


    摘要:Voglmeir, J.; Flitsch, S. L., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 509.
    摘要:Voglmeir, J.; Flitsch, S. L., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 514.
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