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参考文献: Tunable Fluorescence Using Cleavable Linkers[fr] Fluorescence Réglable à L'Aide De Lieurs Clivables
标题: Tunable Fluorescence Using Cleavable Linkers[fr] Fluorescence Réglable à L'Aide De Lieurs Clivables
摘要:这项发明涉及可切割化学反应,特别是利用存在于荧光染料-猝灭剂共轭物中的可切割连接物来实现可调节荧光.

专利信息

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-2010087634-A1
优先权日:2004-12-30
标 题:Fluorous Oligonucleotide Reagents and Affinity Purification of Oligonucleotides
发明人：BERRY DAVID A; PEARSON WILLIAM H
权利人:BERRY & ASSOCIATES INC
摘要:Fluorous-tagged oligonucleotide reagents and an oligonucleotide purification methodology making use thereof, the method comprising: Synthesizing oligonucleotides using oligonucleotide reagents each bearing at least one fluorous group to yield a mixture of synthesis products and reagents, the mixture including at least one target synthesized oligonucleotide bearing at least one fluorous group; passing the mixture through a separation medium having an affinity for the at least one fluorous group so that the target synthesized oligonucleotide bearing at least one fluorous group is adsorbed by the separation medium; washing the separation medium with at least a first solvent to selectively dissociate therefrom substantially all synthesis products and reagents of the heterogenous mixture other than the at least one target synthesized oligonucleotide bearing at least one fluorous group; and subsequently dissociating the at least one synthesized oligonucleotide from the separation medium, with or without the fluorous group.

专利号:US-11959137-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

专利号:US-2024376536-A1
优先权日:2015-09-28
标题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-2022411860-A1
优先权日:2015-09-28
标题:Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-2023160000-A1
优先权日:2015-09-28
标 题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis