专利号:WO-2024137329-A1 优先权日:2022-12-20 标 题:Methods for the synthesis of complement factor d inhibitors and intermediates thereof 发明人:HASHIMOTO AKIHIRO; TIPPARAJU SURESH KUMAR 权利人:ALEXION PHARMA INC 摘要:The present disclosure provides methods for the synthesis of complement factor D inhibitors and intermediates thereof.
专利号:US-6320058-B2 优先权日:2000-02-25 标题:Process for the preparation of isoindoline 发明人:SOUVIE JEAN-CLAUDE; FUGIER CLAUDE; LECOUVE JEAN-PIERRE 权利人:ADIR 摘要:Process for the industrial synthesis of isoindoline by catalytic hydrogenation of phthalonitrile, and its application in the synthesis of 2-(S)-benzyl-4-oxo-4-(cis-perhydroisoindol-2-yl)-butyric acid, its pharmaceutically acceptable salts and its hydrates.
专利号:US-6133454-A 优先权日:1997-07-03 标题:Method for preparing a substituted perhydroisoindole 发明人:LECOUVE JEAN-PIERRE; FUGIER CLAUDE; SOUVIE JEAN-CLAUDE 权利人:ADIR 摘要:The present invention relates to a process for the industrial synthesis of a substituted perhydroisoindole of formula (I): ##STR1## and of pharmaceutically acceptable salts thereof. The compound of formula (I) and its addition salts have especially valuable pharmacological properties. It is a very powerful secretor of insulin, which makes it useful in the treatment of non-insulin-dependent diabetes.
专利号:US-8207339-B2 优先权日:2010-03-19 标 题 :Process for preparing Moxifloxacin and salts thereof 发明人:CASTELLIN ANDREA; PADOVAN PIERLUIGI; JIAGENG LIU; ZHOU YIBO; FENG LIN 权利人:CASTELLIN ANDREA; PADOVAN PIERLUIGI; JIAGENG LIU; ZHOU YIBO; FENG LIN; ITALIANA SINT SPA 摘要:The present invention relates to a process for the synthesis of Moxifloxacin of Formula (I) and salts thereof n nby means of a process providing the coupling reaction of 1-cyclopropril-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo -3-quinolinic acid or ester thereof with (4aS, 7aS) -octahydro-1H-pyrrole[3,4-b]pyridine using a magnesium salt.
专利号:CN-115108962-A 优先权日:2022-08-01 标 题:A kind of method for continuous synthesis of azabicyclic compounds
专利号:CN-115108962-B 优先权日:2022-08-01 标 题:A method for continuous synthesis of azabicyclic compounds