CAS: 19351-18-9; 2,2-Dimethyltetrahydrothiazole

相似化合物

504-78-9 14446-47-0 2682-49-7

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CAS号156-57-0 半胱胺盐酸盐 | CAS号67-64-1 丙酮 | CAS号151-56-4 氮丙啶 | CAS号7783-06-4 硫化氢

半胱胺盐酸盐,丙酮 以 甲醇 用作溶剂,化学反应 24.0H,反应生成2,2-二甲基噻唑烷
参考文献:新型n取代的噻嗪/噻唑衍生物的设计,合成,安全活性和分子对接
标题:新型n取代的噻嗪/噻唑衍生物的设计,合成,安全活性和分子对接
摘要:通过拼接活性基团和生物立体异构体,设计了一系列新颖的取代的噻嗪/噻唑化合物.通过环化,酰化和氨基甲酰化合成标题化合物.所有化合物均通过ir,1 H-NMR,13 C-NMR和hrms进行表征.化合物3F的单晶通过x射线晶体学测定.生物学活性测试表明,所有化合物对除草剂氯磺隆均显示出潜在的更安全活性,其中化合物3E的水平几乎与商业化更安全的ad-67相同.分子对接结果与生物测定结果吻合非常好,表明化合物3E 可能在乙酰乳酸合酶活性位点上与氯磺隆竞争,导致除草剂对玉米无效.
Doi:10.1002/jhet.3393

专利信息

专利号:US-5914431-A
优先权日:1996-09-23
标 题 :Cocatalysts for the synthesis of bisphenols
发明人：FENNHOFF GERHARD
权利人:BAYER AG
摘要:The invention relates to the synthesis of bisphenols from monophenols and carbonyl compounds such as aldehydes and ketones using concentrated mineral acids such as hydrochloric acid and/or hydrogen chloride gas as acid catalysts and a mercaptan as cocatalyst, which is fixed by an ion pair bond to a matrix that is insoluble in the reaction medium.

专利号:US-5698600-A
优先权日:1995-10-24
标题:Process for the production of bisphenols with the use of new cocatalysts
发明人：WULFF CLAUS; FENNHOFF GERHARD; EITEL ALFRED
权利人:BAYER AG
摘要:The invention relates to the synthesis of bisphenols from monophenols and carbonyl compounds such as aldehydes and ketones with concentrated mineral acids such as hydrochloric acid and/or hydrogen chloride gas as acid catalysts and a mercaptan as cocatalyst, which is fixed by an ion-pair bond to a matrix insoluble in the reaction medium.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-7585846-B2
优先权日:2003-11-25
标 题 :Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof
发明人：SHEU SHEY-SHING; ANDERS MARION W; XU LIN; SHARMA VIRENDRA K
权利人:UNIV ROCHESTER
摘要:Disclosed are hydrophilic choline/N-heterocycle ester compounds containing single amino acids, peptides, or derivatives thereof which have the potential to express anti-oxidant activity capable of reducing reactive oxygen species in cells. These compounds may be used to inhibit oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.

专利号:US-2006160748-A1
优先权日:2003-11-25
标 题 :Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof
发明人：SHEU SHEY-SHING; ANDERS MARION W; XU LIN; SHARMA VIRENDRA K; NAUDURI DHANANJAYA
权利人:SHEU SHEY-SHING; ANDERS MARION W; XU LIN; SHARMA VIRENDRA K; NAUDURI DHANANJAYA
摘要:Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.

专利号:DE-112013004111-T5
优先权日:2012-08-23
标题 :Conversion of by-products in the synthesis of bisphenol A