CAS: 2305-36-4; 2-Amino-4-Methylbenzoic Acid

该化合物是一种芳香氨酸,其特点是附于一个甲基代苯环的碳盒酸和氨基功能组,其分子式为C8H9NO2,表明存在8个碳原子,9个氢原子,1个氮原子和2个氧原子.该化合物一般是白色到白色的晶状固体,在水中可溶解,反映其极地功能组.氨基酸组的存在有助于其基本性,而氨基酸组则具有酸性.2-Amino-4-甲基苯甲酸通常用于有机合成,可作为染料,药物和其他化学化合物生产的中间体.此外,它可能展示生物活动,从而引起对药用化学的兴趣.其熔点和具体再活性根据环境条件和纯度而变化,但在标准实验室条件下一般稳定.

英文名称2-Amino-4-Methylbenzoic Acid
中文名称2-氨基-4-甲基苯甲酸
IUPAC名称2-amino-4-methylbenzoic acid
其它别名2-氨基对甲基苯甲酸; Benzoic Acid, 2-Amino-4-Methyl- (9Ci)
CAS编号2305-36-4
MFCD编号:MFCD00047853
EINECS号:218-976-3
FDA UNII编号:2WD667BJ5T
分子式:C8H9NO2
分子量:151.16
产品CID: 1171156
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
产品信息参考;;
InChIKey: RPGKFFKUTVJVPY-UHFFFAOYSA-N
InChI=1S/C8H9NO2/c1-5-2-3-6(8(10)11)7(9)4-5/h2-4H,9H2,1H3,(H,10,11)…
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(经口)
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H302 |吞咽有害.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi,Xn
风险等级Irritant
安全声明26-37/39
危险类别码36/37/38-22

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

合成目标产物 2-Amino-4-Methylbenzoic Acid 主要起始原料 2-Bromo-4-Methylbenzoic Acid
(文献来源)合成步骤主要原料 2-Bromo-4-Methylbenzoic Acid

2-氨基-4-甲基苯甲腈置于氢氧化钾体系中,化学反应生成2-氨基-4-甲基苯甲酸
参考文献:Niementowski,Chemische Berichte,1888,Vol. 21,P. 1539
标题:Niementowski,Chemische Berichte,1888,Vol. 21,P. 1539

海关参考信息

2905110000-甲醇
2906210000-苄醇
2912110000-甲醛
2912210000-苯甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-4154745-A
优先权日:1977-05-02
标题:Isobenzofuran route to anthracycloquinones
发明人：KENDE ANDREW S; TSAY YUH-GENG
权利人:RESEARCH CORP
摘要:There is provided a novel method of synthesizing certain tetracyclic quinones. In particular, there is provided a novel route to the synthesis of (Â±)-7-deoxydaunomycinone and analogs thereof which includes the provision of novel tetrahydronaphthoquinones and tetracyclic quinone intermediates. The compounds of the present invention are provided through a route comprising a Diels-Alder addition of certain isobenzofurans to certain novel tetrahydronaphthoquinones. The products of the synthetic route provided herein may be converted into compounds of known antibiotic and antineoplastic activity.

专利号:US-2015315143-A1
优先权日:2014-05-01
标题 :N-Heterocyclic Carbene-Catalyzed Synthesis of 2-Aryl Indoles

专利号:US-9527812-B2
优先权日:2014-05-01
标题 :N-heterocyclic carbene-catalyzed synthesis of 2-aryl indoles
发明人：SCHEIDT KARL A; HOVEY JR MICHAEL TODD; CHECK CHRISTOPHER
权利人:UNIV NORTHWESTERN
摘要:Transition metal-free catalytic methods for access to 2-arylindole compounds.

专利号:CN-115010671-A
优先权日:2022-07-20
标题:One-step synthesis method of 2-substituted quinazolinone

专利号:US-9328138-B2
优先权日:2011-11-15
标题:HCV NS3 protease inhibitors
发明人：RUDD MICHAEL T; MCCAULEY JOHN; LIVERTON NIGEL; GRISÃ‰-BARD CHRISTIANE; BROCHU MARIE-CHRISTINE; CHARRON SYLVIE; AULAKH VIRENDER; BACHAND BENOIT; BEAULIEU PATRICK; ZAGHDANE HELMI; HAN YONGXIN; FERRARA MARCO; HARPER STEVEN; SUMMA VINCENZO; CHACKALAMANNIL SAMUEL; VENKATRAMAN SRIKANTH; SHAH UNMESH; VELAZQUEZ FRANCISCO
权利人:MERCK SHARP & DOHME; MSD ITALIA SRL; MERCK CANADA INC
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

专利号:US-2013178413-A1
优先权日:2010-09-21
标题 :Hcv ns3 protease inhibitors
发明人：MCCAULEY JOHN A; LIVERTON NIGEL J; RUDD MICHAEL T; GILBERT KEVIN F; FERRARA MARCO; SUMMA VINCENZO; CRESCENZI BENEDETTA
权利人:MCCAULEY JOHN A; LIVERTON NIGEL J; RUDD MICHAEL T; GILBERT KEVIN F; FERRARA MARCO; SUMMA VINCENZO; CRESCENZI BENEDETTA
摘要:The present invention relates to macrocyclic compounds of formula I that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.