CAS: 2949-92-0; S-Methyl Methanesulfonothioate

相似化合物

2949-92-0 13882-12-7 682-91-7

上下游产品

CAS号624-92-0 二甲基二硫醚 | CAS号378784-00-0 rhodium | CAS号676-85-7 甲烷亚磺酰氯 | CAS号124-63-0 甲基磺酰氯 | CAS号94-36-0 过氧化苯甲酰 | CAS号10265-92-6 甲胺磷 | CAS号13882-12-7 Methyl methanet... | CAS号2863-45-8 benzhydryl meth... | CAS号59660-63-8 3,4,5,5-tetrach... | CAS号49844-93-1 2-氯-4-甲硫基嘧啶 | CAS号64-18-6 甲酸 | CAS号75-75-2 甲基磺酸 | CAS号109-87-5 甲缩醛 | CAS号107-31-3 甲酸甲酯 | CAS号3658-80-8 二甲基三硫 | CAS号100-68-5 茴香硫醚 | CAS号55163-92-3 methanesulfinic... | CAS号20873-58-9 5-(甲基硫代)噻吩-2-羧酸 | CAS号59662-65-6 甲巯基甲基对甲苯砜

二甲基二硫置于双氧水体系中,用 溶剂黄146 用作溶剂,化学反应生成甲基硫代磺酸甲酯
参考文献:一种制备2-(甲基或苯硫基硫代)链烷酸酯的新方法
标题:一种制备2-(甲基或苯硫基硫代)链烷酸酯的新方法
摘要:在少量etoh中存在etona的情况下,用ch 3 Sso 2 Ch 3,Phsso 2 Ph或phssph处理后,2-乙酰基链烷酸乙酯以高收率得到2-(甲基或苯硫基)链烷酸乙酯.还描述了本方法在合成肉豆蔻碱和皇后物质中的应用.
Doi:10.1016/s0040-4039(00)88689-X

专利信息

专利号:US-2013267680-A1
优先权日:2010-09-15
标题:Total chemical synthesis of ubiquitin, ubiquitin mutants and derivatives thereof
发明人：OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL
权利人:OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL; STICHTING HET NL KANKERINST
摘要:The present invention relates to the field of total chemical synthesis of ubiquitin and related peptides. More in particular, a method is provided of solid phase synthesis of ubiquitin, ubiquitin mutants and derivatives thereof. It was the object of the present invention to provide an approach for the total chemical synthesis of ubuiqitin, which allows for the chemical synthesis of virtually any Ub mutant and giving high overall efficiency and purity. The present inventors have surprisingly found that this object can be realized with a method relying on incorporation of special amino acid building blocks. This approach was found to allow for exceptionally high yields of up to 14% and to provide an synthetic entry into virtually any ubiquitin derivative.

专利号:US-12378290-B2
优先权日:2019-09-05
标题:Method for protein nanowire synthesis and tunable control of nanowire length
发明人：REGUERA GEMMA; COSERT KRISTA MARIE
权利人:UNIV MICHIGAN STATE
摘要:Methods for synthesizing nanowires are provided. Modified PilA peptides are used as peptide building blocks for synthesizing the nanowires. The method places the peptide building blocks in an assembly buffer with a hydrophobe. Addition of a hydrophobe and molecular crowding by evaporation of the assembly buffer triggers the self-assembly of the peptide building blocks into fibers. Multiple elongation cycles of addition of peptide building blocks, mixing and evaporation are conducted to promote elongation of the fibers and synthesis of nanowires. Electronic characterization of the synthesized nanowires is provided.

专利号:US-9605019-B2
优先权日:2011-07-19
标 题:Methods for the synthesis of functionalized nucleic acids
发明人：VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL
权利人:VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL; WAVE LIFE SCIENCES LTD
摘要:The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages, e.g., oligonucleotides having the structure of IIIa, IIIb or IIIc. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ia or Ib with a silylating reagent to provide a silyloxyphosphonate, and reacting the silyloxyphosphonate with a thiosulfonate reagent of structure IIa or IIb to provide an oligonucleotide of structure IIIa or IIIb. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ic with a silylating reagent to provide a silyloxyphosphonate, reacting the silyloxyphosphonate with a bis(thiosulfonate) reagent of structure IVc to provide a phosphorothiotriester comprising a thiosulfonate group of structure Vc, and then reacting the phosphorothiotriester comprising a thiosulfonate group of structure Vc with a nucleophile of structure VIc to provide an oligonucleotide of structure IIIc.

专利号:US-6627744-B2
优先权日:1999-07-02
标 题 :Synthesis of glycodendrimer reagents
发明人：DAVIS BENJAMIN G; JONES JOHN BRYAN; BOTT RICHARD R
权利人:GENENCOR INT
摘要:The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.

专利号:US-9359394-B2
优先权日:2013-04-08
标题:Stereoselective glycosylation reactions
发明人：BENNETT CLAY S; CHU AN-HSIANG A
权利人:TUFTS COLLEGE
摘要:Disclosed is a method for selective synthesis of 1,2-cis-α-linked glycosides which does not require the use of the specialized protecting group patterns normally employed to control diastereoselectivity. Thioglycoside acceptors can be used, permitting iterative oligosaccharide synthesis. The approach eliminates the need for lengthy syntheses of monosaccharides possessing highly specialized and unconventional protecting group patterns.

专利号:US-6623929-B1
优先权日:1999-04-06
标题:Polynucleotide synthesis using a processing enzyme
发明人：DENSHAM DANIEL HENRY
权利人:MEDICAL BIOSYSTEMS LTD
摘要:The present invention pertains to a method for polynucleotide synthesis, comprising the steps of: (i) reacting a polynucleotide processive enzyme, e.g., a polymerase or TdT, with a nucleotide substrate under conditions suitable for enzyme activity; and (ii) modulating the conformation of the enzyme, e.g. using radiation, to allow incorporation of a predetermined nucleotide.