CAS: 41906-86-9; Nitrocefin

上下游产品

Diphenylmethyl 7β-(2-Thienylacetamido)-3-(Hydroxymethyl)-Cephem-4-Carboxylate 29126-13-4
(6R,7R)-4-Methoxybenzyl-3-(Chloromethyl)-8-Oxo-7-(2-(Thiophen-2-yl)Acetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate 101182-25-6
(6R)-3-Bromomethyl-8-Oxo-7T-(2-Thiophen-2-Yl-Acetylamino)-(6Rh)-5-Thia-1-Aza-Bicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Benzhydryl Ester 30361-56-9
7-氨基头孢烷酸 7-Aminocephalosporanic Acid 957-68-6
羟甲基-7-氨基头孢烷酸 D-7-Aca 15690-38-7

7-氨基头孢烷酸置于水,三溴化磷,Sodium Carbonate,苯甲醚,三氟乙酸,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,二氯甲烷,水,乙酸乙酯,丙酮 作为反应溶剂,化学反应 18.5H,反应生成 头孢硝噻吩
参考文献:头孢硝噻吩的合成方法
标题:头孢硝噻吩的合成方法
摘要:本发明涉及一种头孢硝噻吩的合成方法,属于药物合成领域.本发明提供了一个全新的以化合物i为原料制备头孢硝噻吩的工艺路线.化合物i可利用7‑aca制得.本发明所用制备方法可以7‑aca为起始原料经七步制得头孢硝噻吩.起始原料7‑aca是头孢菌素关键性中间体,且早已产业化,市场价格低廉.本发明操作简单,反应易处理,产物易纯化,收率高,易于工业化,降低了生产成本.

专利信息

专利号:EP-1525305-B1
优先权日:2002-08-02
标题:Methods and compositions for in vitro synthesis of proteins in a cell-free system enriched with atp-sulfurylase
发明人：RYABOVA LYUBOV; MASSON JEAN-MICHEL
权利人:PROTEUS
摘要:The present invention provides methods and composition for enhancing in vitro synthesis of biological macromolecules in a cell-free system where ATP is required as a primary energy source, wherein said cell-free system is enriched with ATP-sulfurylase The invention relates also to as cell-free systems and cell-free extracts enriched with ATP-sulfurylase for enhancing in vitro synthesis of any biological macromolecules.

专利号:US-2005186197-A1
优先权日:2002-08-29
标 题:Peptide inhibitors of beta lactamases
发明人：PALZKILL TIMOTHY; HUANG WANZHI
摘要:Peptide inhibitors of β-lactamases have been identified by the synthesis of peptide arrays using synthesis SPOT technology. These peptide inhibitors of β-lactamase have activity against a broad spectrum of β-lactamases and are useful in a variety of applications.

专利号:US-2013316397-A1
优先权日:2012-04-30
标 题:Cell-Free Polypeptide Synthesis
发明人：AIREN ISOKEN; SWARTZ JAMES ROBERT
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Methods, microbial strains and reaction mixtures for cell-free synthesis of polypeptides are provided. The methods of the invention utilize a reaction mixture comprising microbial cell extracts that are modified in the protein component relative to an extract from a native cell. The modification may be one or both of (i) increased levels of proteins that increase synthetic yield; and (ii) decreased levels of proteins that decrease synthetic yield. The modification may result from a genetic modification of the microbial cell, or from ex vivo supplementation or depletion of an extract.

专利号:US-2006178357-A1
优先权日:2005-02-10
标题 :Chphalosporin-derived mercaptans as inhibitors of serine and metallo-beta-lactamases
发明人：BUYNAK JOHN D; CHEN HANSONG
权利人:BUYNAK JOHN D; CHEN HANSONG
摘要:Compounds of formula I: See Formula I in Figures Section n nwherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting simultaneously serine and metallo-β-lactamase enzymes, for enhancing the activity of β-lactam antibiotics, and for treating β-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.

专利号:US-7022691-B2
优先权日:2002-04-04
标题 :Inhibitors of serine and metallo-β-lactamases
发明人：BUYNAK JOHN D; CHEN HANSONG
权利人:BUYNAK JOHN D; CHEN HANSONG
摘要:Compounds of formula (I): n nwherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting simultaneously serine and metallo-β-lactamase enzymes, for enhancing the activity of β-lactam antibiotics, and for treating β-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.

专利号:US-7125986-B2
优先权日:1997-12-29
标题:Penicillanic acid derivative compounds and methods of making
发明人：BUYNAK JOHN D; RAO AKIREDDY SRINIVASA; DOPPALAPUDI VENKATA RAMANA
权利人:UNIV SOUTHERN METHODIST
摘要:Compounds of formula I: n nwherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting β-lactamase enzymes, for enhancing the activity of β-lactam antibiotics, and for treating β-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.